Search Results - "Doi, Hiroshi"

Proteomic analysis of exosome-enriched fractions derived from cerebrospinal fluid of amyotrophic lateral sclerosis patients by Hayashi, Noriko, Doi, Hiroshi, Kurata, Yoichi, Kagawa, Hiroyuki, Atobe, Yoshitoshi, Funakoshi, Kengo, Tada, Mikiko, Katsumoto, Atsuko, Tanaka, Kenichi, Kunii, Misako, Nakamura, Haruko, Takahashi, Keita, Takeuchi, Hideyuki, Koyano, Shigeru, Kimura, Yayoi, Hirano, Hisashi, Tanaka, Fumiaki

“…•Proteomic analysis was performed on exosome-enriched fractions from CSF of ALS.•Exosome-enriched fractions of CSF revealed increased level of NIR in ALS.•NIR…”
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Gut microbiota and atherosclerosis: role of B cell for atherosclerosis focusing on the gut-immune-B2 cell axis by Chen, Lin, Ishigami, Tomoaki, Doi, Hiroshi, Arakawa, Kentaro, Tamura, Kouichi

“…Atherosclerosis is the leading cause of cardiovascular mortality and morbidity worldwide and is described as a complex disease involving several different cell…”
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The Dynamic Nature of Coronary Artery Lesion Morphology Assessed by Serial Virtual Histology Intravascular Ultrasound Tissue Characterization by Kubo, Takashi, MD, PhD, Maehara, Akiko, MD, Mintz, Gary S., MD, Doi, Hiroshi, MD, PhD, Tsujita, Kenichi, MD, PhD, Choi, So-Yeon, MD, PhD, Katoh, Osamu, MD, Nasu, Kenya, MD, Koenig, Andreas, MD, Pieper, Michael, MD, Rogers, Jason H., MD, Wijns, William, MD, Böse, Dirk, MD, Margolis, M. Pauliina, MD, PhD, Moses, Jeffrey W., MD, Stone, Gregg W., MD, Leon, Martin B., MD

“…Objectives We used virtual histology intravascular ultrasound (VH-IVUS) to investigate the natural history of coronary artery lesion morphology. Background…”
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Long-read sequencing identifies the pathogenic nucleotide repeat expansion in RFC1 in a Japanese case of CANVAS by Nakamura, Haruko, Doi, Hiroshi, Mitsuhashi, Satomi, Miyatake, Satoko, Katoh, Kazutaka, Frith, Martin C, Asano, Tetsuya, Kudo, Yosuke, Ikeda, Takuya, Kubota, Shun, Kunii, Misako, Kitazawa, Yu, Tada, Mikiko, Okamoto, Mitsuo, Joki, Hideto, Takeuchi, Hideyuki, Matsumoto, Naomichi, Tanaka, Fumiaki

“…Recently, a recessively inherited intronic repeat expansion in replication factor C1 (RFC1) was identified in cerebellar ataxia with neuropathy and bilateral…”
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Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome by Tsurusaki, Yoshinori, Okamoto, Nobuhiko, Ohashi, Hirofumi, Kosho, Tomoki, Imai, Yoko, Hibi-Ko, Yumiko, Kaname, Tadashi, Naritomi, Kenji, Kawame, Hiroshi, Wakui, Keiko, Fukushima, Yoshimitsu, Homma, Tomomi, Kato, Mitsuhiro, Hiraki, Yoko, Yamagata, Takanori, Yano, Shoji, Mizuno, Seiji, Sakazume, Satoru, Ishii, Takuma, Nagai, Toshiro, Shiina, Masaaki, Ogata, Kazuhiro, Ohta, Tohru, Niikawa, Norio, Miyatake, Satoko, Okada, Ippei, Mizuguchi, Takeshi, Doi, Hiroshi, Saitsu, Hirotomo, Miyake, Noriko, Matsumoto, Naomichi

“…Naomichi Matsumoto and colleagues report mutations in the SWI/SNF chromatin remodeling complex in Coffin-Siris syndrome. Twenty affected individuals (87%)…”
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Visualization of tumor hypoxia and re-oxygenation after stereotactic body radiation therapy in early peripheral lung cancer: A prospective study by Inada, Masahiro, Nishimura, Yasumasa, Hanaoka, Kohei, Nakamatsu, Kiyoshi, Doi, Hiroshi, Uehara, Takuya, Komanishi, Mikihito, Ishii, Kazunari, Kaida, Hayato, Hosono, Makoto

“…•・Impact of tumor hypoxia and reoxygenation is unclear in area of lung SBRT.•・Hypoxia and reoxygenation were visualized using F-MISO PET in the prospective…”
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Anti-inflammatory effects of siponimod on astrocytes by Ogasawara, Akihiro, Takeuchi, Hideyuki, Komiya, Hiroyasu, Ogawa, Yuki, Nishimura, Koki, Kubota, Shun, Hashiguchi, Shunta, Takahashi, Keita, Kunii, Misako, Tanaka, Kenichi, Tada, Mikiko, Doi, Hiroshi, Tanaka, Fumiaki

“…Siponimod, which is approved to treat active secondary progressive multiple sclerosis, acts as a functional antagonist of sphingosine-1-phosphate (S1P)…”
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New clinical data on human spinal cord re-irradiation tolerance by Doi, Hiroshi, Tamari, Keisuke, Oh, Ryoong-Jin, Nieder, Carsten

“…Purpose To provide additional clinical data about the re-irradiation tolerance of the spinal cord. Methods This was a retrospective bi-institutional study of…”
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Clinicopathologic features of folate-deficiency neuropathy by Koike, Haruki, Takahashi, Mie, Ohyama, Ken, Hashimoto, Rina, Kawagashira, Yuichi, Iijima, Masahiro, Katsuno, Masahisa, Doi, Hiroshi, Tanaka, Fumiaki, Sobue, Gen

“…OBJECTIVE:The clinical significance and characteristics of neuropathy caused by folate deficiency remain to be established. METHODS:We examined the…”
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Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations by Kino, Yoshihiro, Washizu, Chika, Aquilanti, Elisa, Okuno, Misako, Kurosawa, Masaru, Yamada, Mizuki, Doi, Hiroshi, Nukina, Nobuyuki

“…TLS (translocated in liposarcoma), also known as FUS (fused in sarcoma), is an RNA/DNA-binding protein that plays regulatory roles in transcription, pre-mRNA…”
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Experimental Animal Model of Re-irradiation to Evaluate Radiation-induced Damage in the Normal Intestine by Doi, Hiroshi, Tamura, Mikoto, Nakamatsu, Kiyoshi, Monzen, Hajime, Nishimura, Yasumasa

“…We aimed to elucidate the pathological findings following acute and late re-irradiation in a preclinical model. Mice were divided into five treatment groups:…”
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Sensory Ataxic Guillain-Barré Syndrome with Dysgeusia after mRNA COVID-19 Vaccination by Ogata, Shunsuke, Ishii, Yoshito, Asano, Keiichiro, Kobayashi, Erena, Kubota, Shun, Takahashi, Keita, Miyaji, Yosuke, Higashiyama, Yuichi, Joki, Hideto, Doi, Hiroshi, Koga, Michiaki, Takeuchi, Hideyuki, Tanaka, Fumiaki

“…Guillain-Barré syndrome (GBS) has occasionally occurred in people who have received coronavirus disease 2019 (COVID-19) vaccines. Dysgeusia is rare symptom of…”
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Stereotactic body radiotherapy in patients with chronic obstructive pulmonary disease and interstitial pneumonia: a review by Doi, Hiroshi, Nakamatsu, Kiyoshi, Nishimura, Yasumasa

“…Stereotactic body radiation therapy (SBRT) can yield excellent local tumor control, as well as survival benefit comparable to that of surgery for early-stage…”
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Repeat conformation heterogeneity in cerebellar ataxia, neuropathy, vestibular areflexia syndrome by Miyatake, Satoko, Yoshida, Kunihiro, Koshimizu, Eriko, Doi, Hiroshi, Yamada, Mitsunori, Miyaji, Yosuke, Ueda, Naohisa, Tsuyuzaki, Jun, Kodaira, Minori, Onoue, Hiroyuki, Taguri, Masataka, Imamura, Shintaro, Fukuda, Hiromi, Hamanaka, Kohei, Fujita, Atsushi, Satoh, Mai, Miyama, Takabumi, Watanabe, Nobuko, Kurita, Yusuke, Okubo, Masaki, Tanaka, Kenichi, Kishida, Hitaru, Koyano, Shigeru, Takahashi, Tatsuya, Ono, Yoya, Higashida, Kazuhiro, Yoshikura, Nobuaki, Ogata, Katsuhisa, Kato, Rumiko, Tsuchida, Naomi, Uchiyama, Yuri, Miyake, Noriko, Shimohata, Takayoshi, Tanaka, Fumiaki, Mizuguchi, Takeshi, Matsumoto, Naomichi

“…Cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) is a late-onset, slow-progressing multisystem neurodegenerative disorder. Biallelic AAGGG…”
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Matrin 3 Is a Component of Neuronal Cytoplasmic Inclusions of Motor Neurons in Sporadic Amyotrophic Lateral Sclerosis by Tada, Mikiko, Doi, Hiroshi, Koyano, Shigeru, Kubota, Shun, Fukai, Ryoko, Hashiguchi, Shunta, Hayashi, Noriko, Kawamoto, Yuko, Kunii, Misako, Tanaka, Kenichi, Takahashi, Keita, Ogawa, Yuki, Iwata, Ryo, Yamanaka, Shoji, Takeuchi, Hideyuki, Tanaka, Fumiaki

“…Mutations in the MATR3 gene have been identified as a cause of familial amyotrophic lateral sclerosis, but involvement of the matrin 3 (MATR3) protein in…”
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The RNA-binding protein FUS/TLS is a common aggregate-interacting protein in polyglutamine diseases by Doi, Hiroshi, Koyano, Shigeru, Suzuki, Yume, Nukina, Nobuyuki, Kuroiwa, Yoshiyuki

“…Neuronal intranuclear inclusions (NIIs) are the pathological hallmark of polyglutamine (polyQ) diseases. We previously found that the RNA-binding protein…”
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Risk factors for radiation pneumonitis after rotating gantry intensity-modulated radiation therapy for lung cancer by Tatsuno, Saori, Doi, Hiroshi, Okada, Wataru, Inoue, Eri, Nakamatsu, Kiyoshi, Tanooka, Masao, Tanaka, Masahiro, Nishimura, Yasumasa

“…The risk factors for severe radiation pneumonitis (RP) in patients with lung cancer who undergo rotating gantry intensity-modulated radiation therapy (IMRT)…”
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Mutations in POLR3A and POLR3B Encoding RNA Polymerase III Subunits Cause an Autosomal-Recessive Hypomyelinating Leukoencephalopathy by Saitsu, Hirotomo, Osaka, Hitoshi, Sasaki, Masayuki, Takanashi, Jun-ichi, Hamada, Keisuke, Yamashita, Akio, Shibayama, Hidehiro, Shiina, Masaaki, Kondo, Yukiko, Nishiyama, Kiyomi, Tsurusaki, Yoshinori, Miyake, Noriko, Doi, Hiroshi, Ogata, Kazuhiro, Inoue, Ken, Matsumoto, Naomichi

“…Congenital hypomyelinating disorders are a heterogeneous group of inherited leukoencephalopathies characterized by abnormal myelin formation. We have recently…”
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Lubiprostone as a potential therapeutic agent to improve intestinal permeability and prevent the development of atherosclerosis in apolipoprotein E-deficient mice by Arakawa, Kentaro, Ishigami, Tomoaki, Nakai-Sugiyama, Michiko, Chen, Lin, Doi, Hiroshi, Kino, Tabito, Minegishi, Shintaro, Saigoh-Teranaka, Sae, Sasaki-Nakashima, Rie, Hibi, Kiyoshi, Kimura, Kazuo, Tamura, Kouichi

“…The interaction between atherosclerosis and commensal microbes through leaky gut syndrome (LGS), which is characterized by impaired intestinal permeability and…”
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Radiation Pneumonitis After Volumetric Modulated Arc Therapy for Non-small Cell Lung Cancer by Fujiwara, Masayuki, Doi, Hiroshi, Igeta, Masataka, Suzuki, Hitomi, Kitajima, Kazuhiro, Tanooka, Masao, Ishida, Toshihisa, Wakayama, Tsukasa, Yokoi, Takashi, Kuribayashi, Kozo, Kijima, Takashi, Hashimoto, Masaki, Kondo, Nobuyuki, Matsumoto, Seiji, Hasegawa, Seiki, Kamikonya, Norihiko, Yamakado, Koichiro

“…Background/Aim: To evaluate the incidence and grade of radiation pneumonitis after volumetric modulated arc therapy (VMAT) performed for the treatment of…”
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