Search Results - "Dohse, Monika"

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis by Newton, Kim, Wickliffe, Katherine E., Dugger, Debra L., Maltzman, Allie, Roose-Girma, Merone, Dohse, Monika, Kőműves, László, Webster, Joshua D., Dixit, Vishva M.

“…The aspartate-specific cysteine protease caspase-8 suppresses necroptotic cell death mediated by RIPK3 and MLKL. Indeed, mice that lack caspase-8 die in a…”
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Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease by Brendza, Robert, Gao, Xiaoying, Stark, Kimberly L., Lin, Han, Lee, Seung-Hye, Hu, Changyun, Cai, Hao, DiCara, Danielle, Hsiao, Yi-Chun, Ngu, Hai, Foreman, Oded, Baca, Miriam, Dohse, Monika, Fortin, Jean-Phillipe, Corpuz, Racquel, Seshasayee, Dhaya, Easton, Amy, Ayalon, Gai, Hötzel, Isidro, Chih, Ben

“…Parkinson's disease (PD), a neurodegenerative disease affecting dopaminergic (DA) neurons, is characterized by decline of motor function and cognition…”
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XIAP deletion sensitizes mice to TNF-induced and RIP1-mediated death by Witt, Axel, Goncharov, Tatiana, Lee, Yujung Michelle, Kist, Matthias, Dohse, Monika, Eastham, Jeff, Dugger, Debra, Newton, Kim, Webster, Joshua D., Vucic, Domagoj

“…XIAP is a caspase-inhibitory protein that blocks several cell death pathways, and mediates proper activation of inflammatory NOD2-RIP2 signaling. XIAP…”
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Neuroprotection of Host Cells by Human Central Nervous System Stem Cells in a Mouse Model of Infantile Neuronal Ceroid Lipofuscinosis by Tamaki, Stanley J., Jacobs, Yakop, Dohse, Monika, Capela, Alexandra, Cooper, Jonathan D., Reitsma, Michael, He, Dongping, Tushinski, Robert, Belichenko, Pavel V., Salehi, Ahmad, Mobley, William, Gage, Fred H., Huhn, Stephen, Tsukamoto, Ann S., Weissman, Irving L., Uchida, Nobuko

“…Infantile neuronal ceroid lipofuscinosis (INCL) is a fatal neurodegenerative disease caused by a deficiency in the lysosomal enzyme palmitoyl protein…”
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CRISPR/Cas9 Genome Engineering in Engraftable Human Brain-Derived Neural Stem Cells by Dever, Daniel P., Scharenberg, Samantha G., Camarena, Joab, Kildebeck, Eric J., Clark, Joseph T., Martin, Renata M., Bak, Rasmus O., Tang, Yuming, Dohse, Monika, Birgmeier, Johannes A., Jagadeesh, Karthik A., Bejerano, Gill, Tsukamoto, Ann, Gomez-Ospina, Natalia, Uchida, Nobuko, Porteus, Matthew H.

“…Human neural stem cells (NSCs) offer therapeutic potential for neurodegenerative diseases, such as inherited monogenic nervous system disorders, and neural…”
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IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment by Harnoss, Jonathan M, Le Thomas, Adrien, Reichelt, Mike, Guttman, Ofer, Wu, Thomas D, Marsters, Scot A, Shemorry, Anna, Lawrence, David A, Kan, David, Segal, Ehud, Merchant, Mark, Totpal, Klara, Crocker, Lisa M, Mesh, Kathryn, Dohse, Monika, Solon, Margaret, Modrusan, Zora, Rudolph, Joachim, Koeppen, Hartmut, Walter, Peter, Ashkenazi, Avi

“…Cancer cells exploit the unfolded protein response (UPR) to mitigate endoplasmic reticulum (ER) stress caused by cellular oncogene activation and a hostile…”
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Integration of innate immune signalling by caspase-8 cleavage of N4BP1 by Gitlin, Alexander D., Heger, Klaus, Schubert, Alexander F., Reja, Rohit, Yan, Donghong, Pham, Victoria C., Suto, Eric, Zhang, Juan, Kwon, Youngsu C., Freund, Emily C., Kang, Jing, Pham, Anna, Caothien, Roger, Bacarro, Natasha, Hinkle, Trent, Xu, Min, McKenzie, Brent S., Haley, Benjamin, Lee, Wyne P., Lill, Jennie R., Roose-Girma, Merone, Dohse, Monika, Webster, Joshua D., Newton, Kim, Dixit, Vishva M.

“…Mutations in the death receptor FAS 1 , 2 or its ligand FASL 3 cause autoimmune lymphoproliferative syndrome, whereas mutations in caspase-8 or its adaptor…”
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Purified hematopoietic stem cells can differentiate into hepatocytes in vivo by Lagasse, Eric, Connors, Heather, Al-Dhalimy, Muhsen, Reitsma, Michael, Dohse, Monika, Osborne, Linda, Wang, Xin, Finegold, Milton, Weissman, Irving L, Grompe, Markus

“…The characterization of hepatic progenitor cells is of great scientific and clinical interest. Here we report that intravenous injection of adult bone marrow…”
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IRE1α disruption in triple-negative breast cancer cooperates with anti-angiogenic therapy by reversing ER stress adaptation and remodeling the tumor microenvironment by Harnoss, Jonathan M, Le Thomas, Adrien, Reichelt, Mike, Guttman, Ofer, Wu, Thomas D, Marsters, Scot A, Shemorry, Anna, Lawrence, David A, Kan, David, Segal, Ehud, Merchant, Mark, Totpal, Klara, Crocker, Lisa M, Mesh, Kathryn, Dohse, Monika, Solon, Margaret, Modrusan, Zora, Rudolph, Joachim, Koeppen, Hartmut, Walter, Peter, Ashkenazi, Avi

“…Cancer cells exploit the unfolded protein response (UPR) to mitigate endoplasmic reticulum (ER) stress caused by cellular oncogene activation and a hostile…”
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Human neural stem cells induce functional myelination in mice with severe dysmyelination by Uchida, Nobuko, Chen, Kevin, Dohse, Monika, Hansen, Kelly D, Dean, Justin, Buser, Joshua R, Riddle, Art, Beardsley, Douglas J, Wan, Ying, Gong, Xi, Nguyen, Thuan, Cummings, Brian J, Anderson, Aileen J, Tamaki, Stanley J, Tsukamoto, Ann, Weissman, Irving L, Matsumoto, Steven G, Sherman, Larry S, Kroenke, Christopher D, Back, Stephen A

“…Shiverer-immunodeficient (Shi-id) mice demonstrate defective myelination in the central nervous system (CNS) and significant ataxia by 2 to 3 weeks of life…”
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P4-370: Long-term survival of human CNS stem cells and their progeny in immunodeficient, plaque-producing APP transgenic mice by Carlson, George A., Wilson, Calanthe, Young, Rebecca, Turner, Sherry, Westaway, David, Ashe, Karen H., Tsukamoto, Ann, Eckert, Karl, Dohse, Monika, Patel, Priyanka, Tushinski, Robert, Tamaki, Stan, Uchida, Nobuko

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