Search Results - "Dohner, H"

Interactions between comorbidity and treatment of chronic lymphocytic leukemia: results of German Chronic Lymphocytic Leukemia Study Group trials by Goede, Valentin, Cramer, Paula, Busch, Raymonde, Bergmann, Manuela, Stauch, Martina, Hopfinger, Georg, Stilgenbauer, Stephan, Döhner, Hartmut, Westermann, Anne, Wendtner, Clemens M, Eichhorst, Barbara, Hallek, Michael

“…This study investigated the impact of comorbidity in 555 patients with chronic lymphocytic leukemia enrolled in two trials of the German Chronic Lymphocytic…”
Get full text

Disabled older people's use of health and social care services and their unmet care needs in six European countries by Bien, Barbara, McKee, Kevin J, Döhner, Hanneli, Triantafillou, Judith, Lamura, Giovanni, Doroszkiewicz, Halina, Krevers, Barbro, Kofahl, Christopher

“…The national health and social care systems in Europe remain poorly integrated with regard to the care needs of older persons. The present study examined the…”
Get full text

P556: CHANGES IN HEALTH‐RELATED QUALITY OF LIFE IN PATIENTS WITH NEWLY‐DIAGNOSED ACUTE MYELOID LEUKEMIA RECEIVING IVOSIDENIB + AZACITIDINE OR PLACEBO + AZACITIDINE by Schuh, A., Botton, S., Recher, C., Vives Polo, S., Zarzycka, E., Wang, J., Bertani, G., Heuser, M., Calado, R., Yeh, S.‐P., Hui, J., Pandya, S., Gianolio, D., Chamberlain, C., Dohner, H., Montesinos, P.

Get full text

P430: MOLECULAR CHARACTERIZATION OF CLINICAL RESPONSE IN NEWLY‐DIAGNOSED ACUTE MYELOID LEUKEMIA PATIENTS TREATED WITH IVOSIDENIB + AZACITIDINE COMPARED TO PLACEBO + AZACITIDINE by Botton, S., Choe, S., Marchione, D., Montesinos, P., Recher, C., Vives Polo, S., Zarzycka, E., Wang, J., Bertani, G., Heuser, M., Calado, R., Schuh, A., Yeh, S.‐P., Hui, J., Pandya, S., Gianolio, D., Daigle, S., DiNardo, C., Dohner, H.

Get full text

P557: HEMATOLOGIC IMPROVEMENTS WITH IVOSIDENIB + AZACITIDINE COMPARED WITH PLACEBO + AZACITIDINE IN PATIENTS WITH NEWLY‐DIAGNOSED ACUTE MYELOID LEUKEMIA by Dohner, H., Montesinos, P., Vives Polo, S., Zarzycka, E., Wang, J., Bertani, G., Heuser, M., Calado, R., Schuh, A., Yeh, S.‐P., Fuente, A., Cerchione, C., Daigle, S., Hui, J., Pandya, S., Gianolio, D., Recher, C., Botton, S.

Get full text

Integrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA - target gene interactions in acute myeloid leukemia by Russ, A. C., Sander, S., Luck, S. C., Lang, K. M., Bauer, M., Rucker, F. G., Kestler, H. A., Schlenk, R. F., Dohner, H., Holzmann, K., Dohner, K., Bullinger, L.

“…MicroRNAs are regulators of gene expression, which act mainly by decreasing mRNA levels of their multiple targets. Deregulated microRNA expression has been…”
Get full text

High-resolution single-nucleotide polymorphism array-profiling in myeloproliferative neoplasms identifies novel genomic aberrations by STEGELMANN, Frank, BULLINGER, Lars, GRIESSHAMMER, Martin, HOLZMANN, Karlheinz, HABDANK, Marianne, KUHN, Susanne, MAILE, Carmen, SCHAUER, Stefanie, DÖHNER, Hartmut, DÖHNER, Konstanze

“…Single-nucleotide polymorphism arrays allow for genome-wide profiling of copy-number alterations and copy-neutral runs of homozygosity at high resolution. To…”
Get full text

Molecular profiling reveals myeloid leukemia cell lines to be faithful model systems characterized by distinct genomic aberrations by RÜCKER, F. G, SANDER, S, DÖHNER, K, DÖHNER, H, POLLACK, J. R, BULLINGER, L

“…To model and investigate different facets of leukemia pathogenesis, a widely accepted approach is to use immortalized leukemia cell lines. Although these…”
Get full text

11q Deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis by DÖHNER, H, STILGENBAUER, S, JAMES, M. R, BENNER, A, WEILGUNI, T, BENTZ, M, FISCHER, K, HUNSTEIN, W, LICHTER, P

“…Deletions of the long arm of chromosome 11 (11q) are one of the most frequent structural chromosome aberrations in various types of lymphoproliferative…”
Get full text

Impact of serum storage conditions on microRNA stability by Grasedieck, S, Schöler, N, Bommer, M, Niess, J H, Tumani, H, Rouhi, A, Bloehdorn, J, Liebisch, P, Mertens, D, Döhner, H, Buske, C, Langer, C, Kuchenbauer, Florian

Get full text

Protein expression analysis of chromosome 12 candidate genes in chronic lymphocytic leukemia (CLL) by WINKLER, D, SCHNEIDER, C, KRÖBER, A, PASQUALUCCI, L, LICHTER, P, DÖHNER, H, STILGENBAUER, S

“…The pathogenic role of trisomy 12 in chronic lymphocytic leukemia (CLL) remains unresolved, but recently an upregulated RNA expression level has been observed…”
Get full text

DNMT3A mutations in myeloproliferative neoplasms by Stegelmann, F, Bullinger, L, Schlenk, R F, Paschka, P, Griesshammer, M, Blersch, C, Kuhn, S, Schauer, S, Döhner, H, Döhner, K

Get full text

ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia by Pospisilova, S, Gonzalez, D, Malcikova, J, Trbusek, M, Rossi, D, Kater, A P, Cymbalista, F, Eichhorst, B, Hallek, M, Döhner, H, Hillmen, P, van Oers, M, Gribben, J, Ghia, P, Montserrat, E, Stilgenbauer, S, Zenz, T

“…Recent evidence suggests that – in addition to 17p deletion – TP53 mutation is an independent prognostic factor in chronic lymphocytic leukemia (CLL). Data…”
Get full text

Impact of salvage regimens on response and overall survival in acute myeloid leukemia with induction failure by Wattad, M, Weber, D, Döhner, K, Krauter, J, Gaidzik, V I, Paschka, P, Heuser, M, Thol, F, Kindler, T, Lübbert, M, Salih, H R, Kündgen, A, Horst, H-A, Brossart, P, Götze, K, Nachbaur, D, Köhne, C-H, Ringhoffer, M, Wulf, G, Held, G, Salwender, H, Benner, A, Ganser, A, Döhner, H, Schlenk, R F

“…We evaluated the impact of salvage regimens and allogeneic hematopoietic cell transplantation (allo-HCT) in acute myeloid leukemia (AML) with induction…”
Get full text

Incidence and clinical significance of 6q deletions in B cell chronic lymphocytic leukemia by STILGENBAUER, S, BULLINGER, L, BENNER, A, WILDENBERGER, K, BENTZ, M, DÖHNER, K, HO, A. D, LICHTER, P, DÖHNER, H

“…Deletions affecting the long arm of chromosome 6 (6q) are among the most commonly observed chromosomal aberrations in lymphoid malignancies and have been…”
Get full text

Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia by Allegra, D, Bilan, V, Garding, A, Döhner, H, Stilgenbauer, S, Kuchenbauer, F, Mertens, D

“…The MIR-15A/-16-1 tumor suppressor microRNAs (miRNAs) are deleted in leukemic cells from more than 50% of patients with chronic lymphocytic leukemia (CLL). As…”
Get full text

RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features by Gaidzik, V I, Teleanu, V, Papaemmanuil, E, Weber, D, Paschka, P, Hahn, J, Wallrabenstein, T, Kolbinger, B, Köhne, C H, Horst, H A, Brossart, P, Held, G, Kündgen, A, Ringhoffer, M, Götze, K, Rummel, M, Gerstung, M, Campbell, P, Kraus, J M, Kestler, H A, Thol, F, Heuser, M, Schlegelberger, B, Ganser, A, Bullinger, L, Schlenk, R F, Döhner, K, Döhner, H

“…We evaluated the frequency, genetic architecture, clinico-pathologic features and prognostic impact of RUNX1 mutations in 2439 adult patients with…”
Get full text

Cyclosporin A combined with vincristine, doxorubicin and dexamethasone (VAD) compared with VAD alone in patients with advanced refractory multiple myeloma: an EORTC–HOVON randomized phase III study (06914) by Sonneveld, P., Suciu, S., Weijermans, P., Beksac, M., Neuwirtova, R., Solbu, G., Lokhorst, H., Van Der Lelie, J., Dohner, H., Gerhartz, H., Segeren, C. M., Willemze, R., Lowenberg, B.

“…Patients with multiple myeloma (MM) refractory to alkylating agents frequently express P‐glycoprotein (Pgp), which is associated with the multidrug resistance…”
Get full text

Aberrant expression of miR-9/9 in myeloid progenitors inhibits neutrophil differentiation by post-transcriptional regulation of ERG by Nowek, K, Sun, S M, Bullinger, L, Bindels, E M J, Exalto, C, Dijkstra, M K, van Lom, K, Döhner, H, Erkeland, S J, Löwenberg, B, Jongen-Lavrencic, M

“…Aberrant post-transcriptional regulation by microRNAs (miRNAs) has been shown to be involved in the pathogenesis of acute myeloid leukemia (AML). In a previous…”
Get full text

Genomic aberrations in mantle cell lymphoma detected by interphase fluorescence in situ hybridization. Incidence and clinicopathological correlations by Sander, Sandrine, Bullinger, Lars, Leupolt, Elke, Benner, Axel, Kienle, Dirk, Katzenberger, Tiemo, Kalla, Jorg, Ott, German, Muller-Hermelink, Hans Konrad, Barth, Thomas F.E, Moller, Peter, Lichter, Peter, Dohner, Hartmut, Stilgenbauer, Stephan

“…1 Department of Internal Medicine III, University of Ulm; 2 Department of Physiological Chemistry, University of Ulm; 3 Department of Biostatistics, DKFZ,…”
Get full text