Search Results - "Dohi, Toshihiro"

Down-regulation of zinc transporter-1 in astrocytes induces neuropathic pain via the brain-derived neurotrophic factor - K+-Cl− co-transporter-2 signaling pathway in the mouse spinal cord by Kitayama, Tomoya, Morita, Katsuya, Motoyama, Naoyo, Dohi, Toshihiro

“…We previously demonstrated, using a DNA microarray analysis, the down-regulated expression of the slc30a1 gene (zinc transporter 1, ZnT1) in a neuropathic pain…”
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Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain by Dohi, Toshihiro, Morita, Katsuya, Kitayama, Tomoya, Motoyama, Naoyo, Morioka, Norimitsu

“…Injury to peripheral or spinal nerves following either trauma or disease has several consequences including the development of neuropathic pain. This syndrome…”
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Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice by Morita, Katsuya, Motoyama, Naoyo, Kitayama, Tomoya, Morioka, Norimitsu, Kifune, Koki, Dohi, Toshihiro

“…Neuropathic pain is refractory against conventional analgesics, and thus novel medicaments are desired for the treatment. Glycinergic neurons are localized in…”
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Relief of Cancer Pain by Glycine Transporter Inhibitors by Motoyama, Naoyo, Morita, Katsuya, Shiraishi, Seiji, Kitayama, Tomoya, Kanematsu, Takashi, Uezono, Yasuhito, Dohi, Toshihiro

“…BACKGROUND:Recent studies have revealed the antinociceptive effects of glycine transporter (GlyT) inhibitors in neuropathic pain models such as sciatic…”
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Palliation of bone cancer pain by antagonists of platelet-activating factor receptors by Morita, Katsuya, Shiraishi, Seiji, Motoyama, Naoyo, Kitayama, Tomoya, Kanematsu, Takashi, Uezono, Yasuhito, Dohi, Toshihiro

“…Bone cancer pain is the most severe among cancer pain and is often resistant to current analgesics. Thus, the development of novel analgesics effective at…”
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Noradrenaline Induces Clock Gene Per1 mRNA Expression in C6 Glioma Cells Through β2-Adrenergic Receptor Coupled With Protein Kinase A – cAMP Response Element Binding Protein (PKA–CREB) and Src-Tyrosine Kinase – Glycogen Synthase Kinase-3β (Src–GSK-3β) by Morioka, Norimitsu, Sugimoto, Tatsuhiko, Tokuhara, Masato, Dohi, Toshihiro, Nakata, Yoshihiro

“…Astrocytes in the hypothalamic suprachiasmatic nucleus, site of the master circadian pacemaker, play an essential role in the regulation of systemic circadian…”
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Spinal astrocytes contribute to the circadian oscillation of glutamine synthase, cyclooxygenase-1 and clock genes in the lumbar spinal cord of mice by Morioka, Norimitsu, Sugimoto, Tatsuhiko, Tokuhara, Masato, Nakamura, Yoki, Abe, Hiromi, Hisaoka, Kazue, Dohi, Toshihiro, Nakata, Yoshihiro

“…► Circadian rhythms in clock genes expression were detected in the spinal cord. ► Glutamine synthase and cyclooxygenase-1 mRNA was also under circadian…”
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P2X7 receptor stimulation in primary cultures of rat spinal microglia induces downregulation of the activity for glutamate transport by Morioka, Norimitsu, Abdin, Md. Joynal, Kitayama, Tomoya, Morita, Katsuya, Nakata, Yoshihiro, Dohi, Toshihiro

“…It has been shown that spinal microglia expressing certain types of glutamate transporters function in the modulation of neuropathogenesis. In this study, the…”
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Expression and function of variants of human catecholamine transporters lacking the fifth transmembrane region encoded by exon 6 by Sogawa, Chiharu, Mitsuhata, Chieko, Kumagai-Morioka, Kei, Sogawa, Norio, Ohyama, Kazumi, Morita, Katsuya, Kozai, Katsuyuki, Dohi, Toshihiro, Kitayama, Shigeo

“…The transporters for dopamine (DAT) and norepinephrine (NET) are members of the Na+- and Cl--dependent neurotransmitter transporter family SLC6. There is a…”
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Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice by Morita, Katsuya, Morioka, Norimitsu, Abdin, Joynal, Kitayama, Shigeo, Nakata, Yoshihiro, Dohi, Toshihiro

“…Platelet-activating factor (PAF) is a potent inflammatory lipid mediator in peripheral tissues. However, its role in mediation of nociception in central…”
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Cyclic ADP-Ribose Requires FK506-Binding Protein to Regulate Intracellular Ca2+ Dynamics and Catecholamine Release in Acetylcholine-Stimulated Bovine Adrenal Chromaffin Cells by Morita, Katsuya, Kitayama, Tomoya, Kitayama, Shigeo, Dohi, Toshihiro

“…The present study was undertaken to elucidate whether cyclic ADP-ribose (cADPR) mediates the amplification of Ca2+ signaling and catecholamine release via the…”
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Analgesic action of nicotine on tibial nerve transection (TNT)-induced mechanical allodynia through enhancement of the glycinergic inhibitory system in spinal cord by Abdin, Md. Joynal, Morioka, Norimitsu, Morita, Katsuya, Kitayama, Tomoya, Kitayama, Shigeo, Nakashima, Toshikatsu, Dohi, Toshihiro

“…The activation of cholinergic pathways by nicotine elicits various physiological and pharmacological effects in mammals. For example, the stimulation of…”
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Riluzole, a Glutamate Release Inhibitor, Induces Loss of Righting Reflex, Antinociception, and Immobility in Response to Noxious Stimulation in Mice by Irifune, Masahiro, Kikuchi, Nobuhito, Saida, Takuya, Takarada, Tohru, Shimizu, Yoshitaka, Endo, Chie, Morita, Katsuya, Dohi, Toshihiro, Sato, Tomoaki, Kawahara, Michio

“…The general anesthetic state comprises behavioral and perceptual components, including amnesia, unconsciousness, analgesia, and immobility. In vitro,…”
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Cyclic ADP-Ribose Mediates Formyl Methionyl Leucyl Phenylalanine (fMLP)-Induced Intracellular Ca2+Rise and Migration of Human Neutrophils by Morita, Katsuya, Saida, Minoru, Morioka, Norimitsu, Kitayama, Tomoya, Akagawa, Yasumasa, Dohi, Toshihiro

“…Although cyclic ADP-ribose (cADPR), a novel Ca2+-mobilizing mediator, is suggested to be involved in the functions of neutrophils in rodents, its role in human…”
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C-terminal region regulates the functional expression of human noradrenaline transporter splice variants by Sogawa, Chiharu, Kumagai, Kei, Sogawa, Norio, Morita, Katsuya, Dohi, Toshihiro, Kitayama, Shigeo

“…The NET [noradrenaline (norepinephrine) transporter], an Na+/Cl--dependent neurotransmitter transporter, has several isoforms produced by alternative splicing…”
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Stimulation of Cyclic ADP-ribose Synthesis by Acetylcholine and Its Role in Catecholamine Release in Bovine Adrenal Chromaffin Cells by Morita, Katsuya, Kitayama, Shigeo, Dohi, Toshihiro

“…Cyclic ADP-ribose (cADPR) is suggested to be a novel messenger of ryanodine receptors in various cellular systems. However, the regulation of its synthesis in…”
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New development in study of neurotransmitter transporters by Kitayama, Shigeo, Dohi, Toshihiro

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Role of C-terminal region in the functional regulation of rat serotonin transporter (SERT) by Mochizuki, Hideki, Amano, Taku, Seki, Takahiro, Matsubayashi, Hiroaki, Mitsuhata, Chieko, Morita, Katsuya, Kitayama, Shigeo, Dohi, Toshihiro, Mishima, Hiromu K, Sakai, Norio

“…Previously, we revealed that the state of the actin cytoskeleton affects the uptake activity of the serotonin transporter (SERT). Recently, it was reported…”
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Dominant Negative Isoform of Rat Norepinephrine Transporter Produced by Alternative RNA Splicing by Kitayama, S, Ikeda, T, Mitsuhata, C, Sato, T, Morita, K, Dohi, T

“…We have cloned from rat brain a family of alternatively spliced cDNAs from a single gene, which encodes a norepinephrine transporter (NET) having variations at…”
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Functional characterization of the splicing variants of human norepinephrine transporter by Kitayama, Shigeo, Morita, Katsuya, Dohi, Toshihiro

“…Human norepinephrine transporter (NET) displays three splicing variants having different carboxy terminals, hNET, hNET C-t var1 and hNET C-t var2. Functional…”
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