Search Results - "Doherty, Terence"

Perinatal nicotine exposure‐induced transgenerational asthma: Effects of reexposure in F1 gestation by Liu, Jie, Yu, Celia, Doherty, Terence M., Akbari, Omid, Allard, Patrick, Rehan, Virender K.

“…In a rat model, perinatal nicotine exposure results in an epigenetically driven multi‐ and trans‐generationally transmitted asthmatic phenotype that tends to…”
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The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection by Shimada, Kenichi, Chen, Shuang, Dempsey, Paul W, Sorrentino, Rosalinda, Alsabeh, Randa, Slepenkin, Anatoly V, Peterson, Ellena, Doherty, Terence M, Underhill, David, Crother, Timothy R, Arditi, Moshe

“…Here we investigated the role of the Nod/Rip2 pathway in host responses to Chlamydophila pneumoniae-induced pneumonia in mice. Rip2(-/-) mice infected with C…”
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Lack of Toll-Like Receptor 4 or Myeloid Differentiation Factor 88 Reduces Atherosclerosis and Alters Plaque Phenotype in Mice Deficient in Apolipoprotein E by Michelsen, Kathrin S., Wong, Michelle H., Shah, Prediman K., Zhang, Wenxuan, Yano, Juliana, Doherty, Terence M., Akira, Shizuo, Rajavashisth, Tripathi B., Arditi, Moshe, Ignarro, Louis J.

“…Toll-like receptors (TLRs) and the downstream adaptor molecule myeloid differentiation factor 88 (MyD88) play an essential role in the innate immune responses…”
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Diabetes Exacerbates Infection via Hyperinflammation by Signaling through TLR4 and RAGE by Nielsen, Travis B, Pantapalangkoor, Paul, Yan, Jun, Luna, Brian M, Dekitani, Ken, Bruhn, Kevin, Tan, Brandon, Junus, Justin, Bonomo, Robert A, Schmidt, Ann Marie, Everson, Michael, Duncanson, Frederick, Doherty, Terence M, Lin, Lin, Spellberg, Brad

“…For more than a century, diabetic patients have been considered immunosuppressed due to defects in phagocytosis and microbial killing. We confirmed that…”
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Coronary Artery Calcium Score Combined With Framingham Score for Risk Prediction in Asymptomatic Individuals by Greenland, Philip, LaBree, Laurie, Azen, Stanley P, Doherty, Terence M, Detrano, Robert C

“…CONTEXT Guidelines advise that all adults undergo coronary heart disease (CHD) risk assessment to guide preventive treatment intensity. Although the Framingham…”
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Staphylococcus aureus Panton-Valentine leukocidin contributes to inflammation and muscle tissue injury by Tseng, Ching Wen, Kyme, Pierre, Low, Jennifer, Rocha, Miguel A, Alsabeh, Randa, Miller, Loren G, Otto, Michael, Arditi, Moshe, Diep, Binh An, Nizet, Victor, Doherty, Terence M, Beenhouwer, David O, Liu, George Y

“…Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) threatens public health worldwide, and epidemiologic data suggest that the…”
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Staphylococcal Superantigens Use LAMA2 as a Coreceptor To Activate T Cells by Li, Zhigang, Zeppa, Joseph J, Hancock, Mark A, McCormick, John K, Doherty, Terence M, Hendy, Geoffrey N, Madrenas, Joaquín

“…Canonical Ag-dependent TCR signaling relies on activation of the src-family tyrosine kinase LCK. However, staphylococcal superantigens can trigger TCR…”
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Chlamydia pneumoniae-Induced Foam Cell Formation Requires MyD88-Dependent and -Independent Signaling and Is Reciprocally Modulated by Liver X Receptor Activation by Chen, Shuang, Sorrentino, Rosalinda, Shimada, Kenichi, Bulut, Yonca, Doherty, Terence M, Crother, Timothy R, Arditi, Moshe

“…Chlamydia pneumoniae is detected by macrophages and other APCs via TLRs and can exacerbate developing atherosclerotic lesions, but how that occurs is not…”
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TLR Signaling: An Emerging Bridge from Innate Immunity to Atherogenesis by Michelsen, Kathrin S, Doherty, Terence M, Shah, Prediman K, Arditi, Moshe

“…Chronic inflammation and disordered lipid metabolism represent hallmarks of atherosclerosis. Considerable evidence suggests that innate immune defense…”
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Calcification in Atherosclerosis: Bone Biology and Chronic Inflammation at the Arterial Crossroads by Doherty, Terence M., Asotra, Kamlesh, Fitzpatrick, Lorraine A., Qiao, Jian-Hua, Wilkin, Douglas J., Detrano, Robert C., Dunstan, Colin R., Shah, Prediman K., Rajavashisth, Tripathi B.

“…Dystrophic or ectopic mineral deposition occurs in many pathologic conditions, including atherosclerosis. Calcium mineral deposits that frequently accompany…”
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Molecular, Endocrine, and Genetic Mechanisms of Arterial Calcification by Doherty, Terence M, Fitzpatrick, Lorraine A, Inoue, Daisuke, Qiao, Jian-Hua, Fishbein, Michael C, Detrano, Robert C, Shah, Prediman K, Rajavashisth, Tripathi B

“…Pathologists have recognized arterial calcification for over a century. Recent years have witnessed a strong resurgence of interest in atherosclerotic plaque…”
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Transferrin Iron Starvation Therapy for Lethal Bacterial and Fungal Infections by Lin, Lin, Pantapalangkoor, Paul, Tan, Brandon, Bruhn, Kevin W., Ho, Tiffany, Nielsen, Travis, Skaar, Eric P., Zhang, Yaofang, Bai, Ruipeng, Wang, Amy, Doherty, Terence M., Spellberg, Brad

“…New strategies to treat antibiotic-resistant infections are urgently needed. We serendipitously discovered that stem cell conditioned media possessed broad…”
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TB, or not TB: that is the question -- does TLR signaling hold the answer? by Doherty, Terence M, Arditi, Moshe

“…Innate immunity critically depends on signaling by Toll-like receptors (TLRs) that rely heavily on an intracellular adapter protein called myeloid…”
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Transforming Growth Factor-β Differentially Inhibits MyD88-dependent, but Not TRAM- and TRIF-dependent, Lipopolysaccharide-induced TLR4 Signaling by Naiki, Yoshikazu, Michelsen, Kathrin S., Zhang, Wenxuang, Chen, Shuang, Doherty, Terence M., Arditi, Moshe

“…Transforming growth factor-β1 (TGF-β1) is a multifunctional, potent anti-inflammatory cytokine produced by many cell types that regulates cell proliferation,…”
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TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis by Naiki, Yoshikazu, Sorrentino, Rosalinda, Wong, Michelle H, Michelsen, Kathrin S, Shimada, Kenichi, Chen, Shuang, Yilmaz, Atilla, Slepenkin, Anatoly, Schröder, Nicolas W J, Crother, Timothy R, Bulut, Yonca, Doherty, Terence M, Bradley, Michelle, Shaposhnik, Zory, Peterson, Ellena M, Tontonoz, Peter, Shah, Prediman K, Arditi, Moshe

“…Experimental and clinical studies link Chlamydia pneumoniae infection to atherogenesis and atherothrombotic events, but the underlying mechanisms are unclear…”
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Biomarkers for prediction of skeletal disease progression in mucopolysaccharidosis type I by Lund, Troy C., Doherty, Terence M., Eisengart, Julie B., Freese, Rebecca L., Rudser, Kyle D., Fung, Ellen B., Miller, Bradley S., White, Klane K., Orchard, Paul J., Whitley, Chester B., Polgreen, Lynda E.

“…Background Orthopedic disease progresses in mucopolysaccharidosis type I (MPS I), even with approved therapies and remains a major factor in persistent…”
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Involvement of Innate and Adaptive Immunity in a Murine Model of Coronary Arteritis Mimicking Kawasaki Disease by Schulte, Danica J, Yilmaz, Atilla, Shimada, Kenichi, Fishbein, Michael C, Lowe, Emily L, Chen, Shuang, Wong, Michelle, Doherty, Terence M, Lehman, Thomas, Crother, Timothy R, Sorrentino, Rosalinda, Arditi, Moshe

“…Kawasaki disease (KD) is the most common cause of acquired cardiac disease and acute vasculitis in children in the developed world. Injection of a cell wall…”
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Murine model of Hirschsprung-associated enterocolitis. I: Phenotypic characterization with development of a histopathologic grading system by Cheng, Zhi, Dhall, Deepti, Zhao, Lifu, Wang, Hanlin L, Doherty, Terence M, Bresee, Catherine, Frykman, Philip K

“…Abstract Purpose The aim of the study was to characterize enterocolitis in the Ednrb-null (Ednrb−/−) mouse with aganglionosis of the colon and to develop and…”
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Chlamydial Heat Shock Protein 60 Induces Acute Pulmonary Inflammation in Mice via the Toll-Like Receptor 4- and MyD88-Dependent Pathway by BULUT, Yonca, SHIMADA, Kenichi, WONG, Michelle H, SHUANG CHEN, GRAY, Pearl, ALSABEH, Randa, DOHERTY, Terence M, CROTHER, Timothy R, ARDITI, Moshe

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A Humoral Immune Response Alters the Distribution of Enzyme Replacement Therapy in Murine Mucopolysaccharidosis Type I by Le, Steven Q, Kan, Shih-Hsin, Clarke, Don, Sanghez, Valentina, Egeland, Martin, Vondrak, Kristen N, Doherty, Terence M, Vera, Moin U, Iacovino, Michelina, Cooper, Jonathan D, Sands, Mark S, Dickson, Patricia I

“…Antibodies against recombinant proteins can significantly reduce their effectiveness in unanticipated ways. We evaluated the humoral response of mice with the…”
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