Search Results - "Doherty, Peter"

What have we learnt so far from COVID-19? by Doherty, Peter C.

“…While COVID-19 shows us the enormous power of modern molecular medicine, it also reminds us of the basic contradictions and limitations of the human condition…”
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The origins of SARS-CoV-2: A critical review by Holmes, Edward C., Goldstein, Stephen A., Rasmussen, Angela L., Robertson, David L., Crits-Christoph, Alexander, Wertheim, Joel O., Anthony, Simon J., Barclay, Wendy S., Boni, Maciej F., Doherty, Peter C., Farrar, Jeremy, Geoghegan, Jemma L., Jiang, Xiaowei, Leibowitz, Julian L., Neil, Stuart J.D., Skern, Tim, Weiss, Susan R., Worobey, Michael, Andersen, Kristian G., Garry, Robert F., Rambaut, Andrew

“…Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest…”
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Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18–dependent activation by Loh, Liyen, Wang, Zhongfang, Sant, Sneha, Koutsakos, Marios, Jegaskanda, Sinthujan, Corbett, Alexandra J., Liu, Ligong, Fairlie, David P., Crowe, Jane, Rossjohn, Jamie, Xu, Jianqing, Doherty, Peter C., McCluskey, James, Kedzierska, Katherine

“…Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes known to elicit potent immunity to a broad range of bacteria, mainly via the rapid…”
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The Origin of COVID-19 and Why It Matters by Morens, David M, Breman, Joel G, Calisher, Charles H, Doherty, Peter C, Hahn, Beatrice H, Keusch, Gerald T, Kramer, Laura D, LeDuc, James W, Monath, Thomas P, Taubenberger, Jeffery K

“…The COVID-19 pandemic is among the deadliest infectious diseases to have emerged in recent history. As with all past pandemics, the specific mechanism of its…”
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Sizing up the key determinants of the CD8+ T cell response by Tscharke, David C., Croft, Nathan P., Doherty, Peter C., La Gruta, Nicole L.

“…Key Points Cytotoxic T lymphocytes (CTLs) are increasingly being recognized as crucial components of antiviral immunity. Nevertheless, there remains much…”
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Suboptimal SARS-CoV-2−specific CD8⁺ T cell response associated with the prominent HLA-A02: 01 phenotype by Habel, Jennifer R., Nguyen, Thi H. O., van de Sandt, Carolien E., Juno, Jennifer A., Chaurasia, Priyanka, Wragg, Kathleen, Koutsakos, Marios, Hensen, Luca, Jia, Xiaoxiao, Chua, Brendon, Zhang, Wuji, Tan, Hyon-Xhi, Flanagan, Katie L., Doolan, Denise L., Torresi, Joseph, Chen, Weisan, Wakim, Linda M., Cheng, Allen C., Doherty, Peter C., Petersen, Jan, Rossjohn, Jamie, Wheatley, Adam K., Kent, Stephen J., Rowntree, Louise C., Kedzierska, Katherine

“…An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strategies. Experience with…”
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Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection by Lupfer, Christopher, Thomas, Paul G, Anand, Paras K, Vogel, Peter, Milasta, Sandra, Martinez, Jennifer, Huang, Gonghua, Green, Maggie, Kundu, Mondira, Chi, Hongbo, Xavier, Ramnik J, Green, Douglas R, Lamkanfi, Mohamed, Dinarello, Charles A, Doherty, Peter C, Kanneganti, Thirumala-Devi

“…Autophagocytic disposal of mitochondria (mitophagy) is important for regulating inflammation. Kanneganti and colleagues show that RIP2 kinase–initiated…”
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This Scientific Life by Doherty, Peter C

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Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection by Wang, Zhongfang, Zhang, Anli, Wan, Yanmin, Liu, Xinian, Qiu, Chao, Xi, Xiuhong, Ren, Yanqin, Wang, Jing, Dong, Yuan, Bao, Meijuan, Li, Liangzhu, Zhou, Mingzhe, Yuan, Songhua, Sun, Jun, Zhu, Zhaoqin, Chen, Liang, Li, Qingsheng, Zhang, Zhiyong, Zhang, Xiaoyan, Lu, Shuihua, Doherty, Peter C., Kedzierska, Katherine, Xu, Jianqing

“…A unique avian-origin A/H7N9 influenza virus has so far caused 134 cases with 44 deaths. Probing the host factors contributing to disease severity, we found…”
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Structural determinants of T-cell receptor bias in immunity by Turner, Stephen J, Doherty, Peter C, McCluskey, James, Rossjohn, Jamie

“…Antigen-specific T-cell responses induced by infection, transplantation, autoimmunity or hypersensitivity are characterized by cells expressing biased profiles…”
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Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8+ T cells by Wang, Zhongfang, Wan, Yanmin, Qiu, Chenli, Quiñones-Parra, Sergio, Zhu, Zhaoqin, Loh, Liyen, Tian, Di, Ren, Yanqin, Hu, Yunwen, Zhang, Xiaoyan, Thomas, Paul G., Inouye, Michael, Doherty, Peter C., Kedzierska, Katherine, Xu, Jianqing

“…The avian origin A/H7N9 influenza virus causes high admission rates (>99%) and mortality (>30%), with ultimately favourable outcomes ranging from rapid…”
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Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease by Wang, Zhongfang, Zhu, Lingyan, Nguyen, Thi H. O., Wan, Yanmin, Sant, Sneha, Quiñones-Parra, Sergio M., Crawford, Jeremy Chase, Eltahla, Auda A., Rizzetto, Simone, Bull, Rowena A., Qiu, Chenli, Koutsakos, Marios, Clemens, E. Bridie, Loh, Liyen, Chen, Tianyue, Liu, Lu, Cao, Pengxing, Ren, Yanqin, Kedzierski, Lukasz, Kotsimbos, Tom, McCaw, James M., La Gruta, Nicole L., Turner, Stephen J., Cheng, Allen C., Luciani, Fabio, Zhang, Xiaoyan, Doherty, Peter C., Thomas, Paul G., Xu, Jianqing, Kedzierska, Katherine

“…Severe influenza A virus (IAV) infection is associated with immune dysfunction. Here, we show circulating CD8 + T-cell profiles from patients hospitalized with…”
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T cell receptor αβ diversity inversely correlates with pathogen-specific antibody levels in human cytomegalovirus infection by Wang, George C, Dash, Pradyot, McCullers, Jonathan A, Doherty, Peter C, Thomas, Paul G

“…A diverse T cell receptor (TCR) repertoire capable of recognizing a broad range of antigenic peptides is thought to be central to effective pathogen-specific…”
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Respiratory epithelial cells in innate immunity to influenza virus infection by Sanders, Catherine J, Doherty, Peter C, Thomas, Paul G

“…Infection by influenza virus leads to respiratory failure characterized by acute lung injury associated with alveolar edema, necrotizing bronchiolitis, and…”
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The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1 by Thomas, Paul G., Dash, Pradyot, Aldridge, Jerry R., Ellebedy, Ali H., Reynolds, Cory, Funk, Amy J., Martin, William J., Lamkanfi, Mohamed, Webby, Richard J., Boyd, Kelli L., Doherty, Peter C., Kanneganti, Thirumala-Devi

“…Virus-induced interlukin-1β (IL-1β) and IL-18 production in macrophages are mediated via caspase-1 pathway. Multiple microbial components, including viral RNA,…”
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The effect of charging time on the comparative environmental performance of different vehicle types by Crossin, Enda, Doherty, Peter J.B.

“…•The environmental performance of a PHEV and equivalent ICE were analysed using LCA.•Charging behaviour and electricity profiles of Australia’s NEM grid were…”
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Recalling the Future: Immunological Memory Toward Unpredictable Influenza Viruses by Auladell, Maria, Jia, Xiaoxiao, Hensen, Luca, Chua, Brendon, Fox, Annette, Nguyen, Thi H O, Doherty, Peter C, Kedzierska, Katherine

“…Persistent and durable immunological memory forms the basis of any successful vaccination protocol. Generation of pre-existing memory B cell and T cell pools…”
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Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells by Quinn, Kylie M., Fox, Annette, Harland, Kim L., Russ, Brendan E., Li, Jasmine, Nguyen, Thi H.O., Loh, Liyen, Olshanksy, Moshe, Naeem, Haroon, Tsyganov, Kirill, Wiede, Florian, Webster, Rosela, Blyth, Chantelle, Sng, Xavier Y.X., Tiganis, Tony, Powell, David, Doherty, Peter C., Turner, Stephen J., Kedzierska, Katherine, La Gruta, Nicole L.

“…Age-associated decreases in primary CD8+ T cell responses occur, in part, due to direct effects on naive CD8+ T cells to reduce intrinsic functionality, but…”
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COVID-19 and beyond by Doherty, Peter C.

“…A media mantra is that, harking back to the 1918–19 influenza pandemic, COVID-19 is a 100-year event. Apart from ignoring the ongoing (from 1981) HIV/AIDS…”
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Preexisting CD8⁺ T-cell immunity to the H7N9 influenza A virus varies across ethnicities by Quiñones-Parra, Sergio, Grant, Emma, Loh, Liyen, Nguyen, Thi H. O., Campbell, Kristy-Anne, Tong, Steven Y. C., Miller, Adrian, Doherty, Peter C., Vijaykrishna, Dhanasekaran, Rossjohn, Jamie, Gras, Stephanie, Kedzierska, Katherine

“…The absence of preexisting neutralizing antibodies specific for the novel A (H7N9) influenza virus indicates a lack of prior human exposure. As influenza A…”
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