Search Results - "Doherty, PC"

P19-24. Evaluation of recombinant influenza-SIV vaccines in macaques by Stambas, J, Sexton, A, De Rose, R, Reece, JC, Alcantara, S, Loh, L, Moffat, JM, Laurie, K, Hurt, A, Doherty, PC, Turner, SJ, Kent, SJ

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Influenza and the challenge for immunology by Doherty, Peter C, Turner, Stephen J, Webby, Richard G, Thomas, Paul G

“…The continued westward dissemination of H5N1 influenza A viruses in avian populations and the nearly 50% mortality rate of humans infected with H5N1 are a…”
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Cell-mediated protection in influenza infection by Thomas, Paul G, Keating, Rachael, Hulse-Post, Diane J, Doherty, Peter C

“…Current vaccine strategies against influenza focus on generating robust antibody responses. Because of the high degree of antigenic drift among circulating…”
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The Collagen Binding alpha 1 beta 1 Integrin VLA-1 Regulates CD8 T Cell-Mediated Immune Protection against Heterologous Influenza Infection by Ray, S J, Franki, S N, Pierce, R H, Dimitrova, S, Koteliansky, V, Sprague, A G, Doherty, P C, De Fougerolles, AR, Topham, D J

“…A common feature of many infections is that many pathogen-specific memory T cells become established in diverse nonlymphoid tissues. A mechanism that promotes…”
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Hierarchies in Cytokine Expression Profiles for Acute and Resolving Influenza Virus-Specific CD8+ T Cell Responses: Correlation of Cytokine Profile and TCR Avidity by La Gruta, Nicole L, Turner, Stephen J, Doherty, Peter C

“…The development and resolution phases of influenza-specific CD8(+) T cell cytokine responses to epitopes derived from the viral nucleoprotein (D(b)NP(366)) and…”
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A Virus-Specific CD8⁺ T Cell Immunodominance Hierarchy Determined by Antigen Dose and Precursor Frequencies by La Gruta, Nicole L., Kedzierska, Katherine, Pang, Ken, Webby, Richard, Davenport, Miles, Chen, Weisan, Turner, Stephen J., Doherty, Peter C.

“…Immunodominance hierarchies are a substantial, but poorly understood, characteristic of CD8⁺ T cell-mediated immunity. Factors influencing the differential…”
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Compromised Influenza Virus-Specific CD8+-T-Cell Memory in CD4+-T-Cell-Deficient Mice by Belz, Gabrielle T, Wodarz, Dominik, Diaz, Gabriela, Nowak, Martin A, Doherty, Peter C

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Accessing Complexity: The Dynamics of Virus-Specific T Cell Responses by Doherty, Peter C, Christensen, Jan P

“…The cellular dynamics of the immune system are complex and difficult to measure. Access to this problematic area has been greatly enhanced by the recent…”
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Conserved T Cell Receptor Usage in Primary and Recall Responses to an Immunodominant Influenza Virus Nucleoprotein Epitope by Kedzierska, Katherine, Turner, Stephen J., Doherty, Peter C.

“…The CD8+ T cell response to the immunodominant D b NP366 epitope has been analyzed sequentially to determine the prevalence and persistence of different T cell…”
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CD8+ T cells clear influenza virus by perforin or Fas-dependent processes by Topham, DJ, Tripp, RA, Doherty, PC

“…Influenza virus infection is controlled in CD4-depleted mice that are also defective for the expression of either Fas (Fas-/-) or perforin (P-/-). Virus-immune…”
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Analysis of Clonotype Distribution and Persistence for an Influenza Virus-Specific CD8 + T Cell Response by Turner, Stephen J, Diaz, Gabriela, Cross, Richard, Doherty, Peter C

“…The spectrum of TCR Vβ usage is compared for primary and recall CD8 +D bPA 224 + T cell responses in mice with influenza pneumonia. Single-cell RT-PCR…”
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Differential antigen presentation regulates the changing patterns of CD8+ T cell immunodominance in primary and secondary influenza virus infections by Crowe, Sherry R, Turner, Stephen J, Miller, Shannon C, Roberts, Alan D, Rappolo, Rachel A, Doherty, Peter C, Ely, Kenneth H, Woodland, David L

“…The specificity of CD8+ T cell responses can vary dramatically between primary and secondary infections. For example, NP366-374/Db- and PA224-233/Db-specific…”
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A previously unrecognized H-2D(b)-restricted peptide prominent in the primary influenza A virus-specific CD8(+) T-cell response is much less apparent following secondary challenge by Belz, G T, Xie, W, Altman, J D, Doherty, P C

“…Respiratory challenge of H-2(b) mice with an H3N2 influenza A virus causes an acute, transient pneumonitis characterized by the massive infiltration of CD8(+)…”
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Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses by Lipatov, Aleksandr S, Andreansky, Samita, Webby, Richard J, Hulse, Diane J, Rehg, Jerold E, Krauss, Scott, Perez, Daniel R, Doherty, Peter C, Webster, Robert G, Sangster, Mark Y

“…1 Department of Infectious Diseases (Division of Virology), St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105–2794, USA 2…”
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Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8 + T cell populations by Turner, Stephen J, Kedzierska, Katherine, Komodromou, Helen, La Gruta, Nicole L, Dunstone, Michelle A, Webb, Andrew I, Webby, Richard, Walden, Helen, Xie, Wiedong, McCluskey, James, Purcell, Anthony W, Rossjohn, Jamie, Doherty, Peter C

“…Using both 'reverse genetics' and structural analysis, we have examined the in vivo relationship between antigenicity and T cell receptor (TCR) repertoire…”
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Virus-Specific CD8 + T Cells in Primary and Secondary Influenza Pneumonia by Flynn, Kirsten J, Belz, Gabrielle T, Altman, John D, Ahmed, Rafi, Woodland, David L, Doherty, Peter C

“…Virus-specific CD8 + effector T cells (eCTL) are enriched in the lungs of mice with primary influenza pneumonia, though later detection of memory T cells…”
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Inhibition of MHC Class I-Restricted Antigen Presentation by γ 2-Herpesviruses by Stevenson, Philip G., Efstathiou, Stacey, Doherty, Peter C., Lehner, Paul J.

“…The γ -herpesviruses, in contrast to the α - and β -herpesviruses, are not known to inhibit antigen presentation to CD8+cytotoxic T lymphocytes (CTLs) during…”
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Measuring the Diaspora for Virus-Specific CD8+T cells by Marshall, Dana R., Turner, Stephen J., Belz, Gabrielle T., Wingo, Suzette, Andreansky, Samita, Sangster, Mark Y., Riberdy, Janice M., Liu, Tiebin, Tan, Ming, Doherty, Peter C.

“…The CD8+T cell diaspora has been analyzed after secondary challenge with an influenza A virus that replicates only in the respiratory tract. Numbers of DbNP…”
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Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells by Cardin, R D, Brooks, J W, Sarawar, S R, Doherty, P C

“…A unique experimental model has been developed for dissecting the integrity of CD8+ T cell-mediated immunity to a persistent gammaherpesvirus under conditions…”
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Diversity of Epitope and Cytokine Profiles for Primary and Secondary Influenza A Virus-Specific CD8+ T Cell Responses by Belz, Gabrielle T, Xie, Weidong, Doherty, Peter C

“…Screening with the flow cytometric IFN-gamma assay has led to the identification of a new immunogenic peptide (SSYRRPVGI) [corrected] from the influenza PB1…”
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