Search Results - "Doherty, Laura M."

Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes by Doherty, Laura M, Mills, Caitlin E, Boswell, Sarah A, Liu, Xiaoxi, Hoyt, Charles Tapley, Gyori, Benjamin, Buhrlage, Sara J, Sorger, Peter K

“…Deubiquitinating enzymes (DUBs), ~100 of which are found in human cells, are proteases that remove ubiquitin conjugates from proteins, thereby regulating…”
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Advances in Discovering Deubiquitinating Enzyme (DUB) Inhibitors by Schauer, Nathan J, Magin, Robert S, Liu, Xiaoxi, Doherty, Laura M, Buhrlage, Sara J

“…Deubiquitinating enzymes, or DUBs, comprise a family of proteases that regulate ubiquitination dynamics. Since their discovery, genetic and functional studies…”
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Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion by Harris, Isaac S., Endress, Jennifer E., Coloff, Jonathan L., Selfors, Laura M., McBrayer, Samuel K., Rosenbluth, Jennifer M., Takahashi, Nobuaki, Dhakal, Sabin, Koduri, Vidyasagar, Oser, Matthew G., Schauer, Nathan J., Doherty, Laura M., Hong, Andrew L., Kang, Yun Pyo, Younger, Scott T., Doench, John G., Hahn, William C., Buhrlage, Sara J., DeNicola, Gina M., Kaelin, William G., Brugge, Joan S.

“…Cells are subjected to oxidative stress during the initiation and progression of tumors, and this imposes selective pressure for cancer cells to adapt…”
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Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism by Schauer, Nathan J., Liu, Xiaoxi, Magin, Robert S., Doherty, Laura M., Chan, Wai Cheung, Ficarro, Scott B., Hu, Wanyi, Roberts, Rebekka M., Iacob, Roxana E., Stolte, Björn, Giacomelli, Andrew O., Perera, Sumner, McKay, Kyle, Boswell, Sarah A., Weisberg, Ellen L., Ray, Arghya, Chauhan, Dharminder, Dhe-Paganon, Sirano, Anderson, Ken C., Griffin, James D., Li, Jianing, Hahn, William C., Sorger, Peter K., Engen, John R., Stegmaier, Kimberly, Marto, Jarrod A., Buhrlage, Sara J.

“…Ubiquitin specific peptidase 7 (USP7) is a deubiquitinating enzyme (DUB) that removes ubiquitin tags from specific protein substrates in order to alter their…”
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B12-Mediated, Long Wavelength Photopolymerization of Hydrogels by Rodgers, Zachary L, Hughes, Robert M, Doherty, Laura M, Shell, Jennifer R, Molesky, Brian P, Brugh, Alexander M, Forbes, Malcolm D. E, Moran, Andrew M, Lawrence, David S

“…Medical hydrogel applications have expanded rapidly over the past decade. Implantation in patients by noninvasive injection is preferred, but this requires…”
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B 12 -Mediated, Long Wavelength Photopolymerization of Hydrogels by Rodgers, Zachary L., Hughes, Robert M., Doherty, Laura M., Shell, Jennifer R., Molesky, Brian P., Brugh, Alexander M., Forbes, Malcolm D. E., Moran, Andrew M., Lawrence, David S.

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Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma by Lee, Patrick C, Klaeger, Susan, Le, Phuong M, Korthauer, Keegan, Cheng, Jingwei, Ananthapadmanabhan, Varsha, Frost, Thomas C, Stevens, Jonathan D, Wong, Alan Yl, Iorgulescu, J Bryan, Tarren, Anna Y, Chea, Vipheaviny A, Carulli, Isabel P, Lemvigh, Camilla K, Pedersen, Christina B, Gartin, Ashley K, Sarkizova, Siranush, Wright, Kyle T, Li, Letitia W, Nomburg, Jason, Li, Shuqiang, Huang, Teddy, Liu, Xiaoxi, Pomerance, Lucas, Doherty, Laura M, Apffel, Annie M, Wallace, Luke J, Rachimi, Suzanna, Felt, Kristen D, Wolff, Jacquelyn O, Witten, Elizabeth, Zhang, Wandi, Neuberg, Donna, Lane, William J, Zhang, Guanglan, Olsen, Lars R, Thakuria, Manisha, Rodig, Scott J, Clauser, Karl R, Starrett, Gabriel J, Doench, John G, Buhrlage, Sara J, Carr, Steven A, DeCaprio, James A, Wu, Catherine J, Keskin, Derin B

“…Cancers avoid immune surveillance through an array of mechanisms, including perturbation of HLA class I antigen presentation. Merkel cell carcinoma (MCC) is an…”
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Virally mediated mechanisms of HLA class I loss in Merkel cell carcinoma and implications for viral epitope presentation by Keskin, Derin B., Lee, Patrick C., Klaeger, Susan, Le, Phuong M., Korthauer, Keegan, Cheng, Jingwei, Ananthapadmanabhan, Varsha, Frost, Thomas C., Iorgulescu, J. Bryan, Lemvigh, Camilla K., Pedersen, Christina B., Sarkizova, Siranush, Li, Shuqiang, Liu, Xiaoxi, Doherty, Laura M., Neuberg, Donna, Zhang, Guanglan, Olsen, Lars R., Thakuria, Manisha, Rodig, Scott J., Clauser, Karl R., Starrett, Gabriel J., Doench, John G., Buhrlage, Sara J., Carr, Steven A., DeCaprio, James A., Wu, Catherine J.

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Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma by Lee, Patrick C, Klaeger, Susan, Le, Phuong M, Korthauer, Keegan, Cheng, Jingwei, Ananthapadmanabhan, Varsah, Frost, Thomas C, Stevens, Jonathan D, Wong, Alan Y.L, Iorgulescu, Bryan

“…Cancers avoid immune surveillance through an array of mechanisms, including perturbation of HLA class I antigen presentation. Merkel cell carcinoma (MCC) is an…”
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B(12)-mediated, long wavelength photopolymerization of hydrogels by Rodgers, Zachary L, Hughes, Robert M, Doherty, Laura M, Shell, Jennifer R, Molesky, Brian P, Brugh, Alexander M, Forbes, Malcolm D E, Moran, Andrew M, Lawrence, David S

“…Medical hydrogel applications have expanded rapidly over the past decade. Implantation in patients by noninvasive injection is preferred, but this requires…”
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Reference frame for rapid visual processing of line orientation by Doherty, L M, Foster, D H

“…Detection of a uniquely oriented line element in a background field of uniformly oriented line elements depends on the orientation of the background field. Is…”
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Limitations of rapid parallel processing in the detection of long and short oriented line targets by Doherty, L M, Foster, D H

“…The purpose of this study was to determine whether the detectability of a uniquely oriented line element in a field of uniformly oriented line elements depends…”
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Quantitative determination of nuclear estrogen receptors by an enzyme immunoassay: applicability and caveats by Kral, L G, Doherty, L M, Brooks, S C

“…A method is presented with which approx. 95% of nuclear estrogen receptors appear to be extracted from MCF-7 cells. Since both nuclear isolation and nuclear…”
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