Search Results - "Doherty, J A"

A non-canonical mismatch repair pathway in prokaryotes by Castañeda-García, A., Prieto, A. I., Rodríguez-Beltrán, J., Alonso, N., Cantillon, D., Costas, C., Pérez-Lago, L., Zegeye, E. D., Herranz, M., Plociński, P., Tonjum, T., García de Viedma, D., Paget, M., Waddell, S. J., Rojas, A. M., Doherty, A. J., Blázquez, J.

“…Mismatch repair (MMR) is a near ubiquitous pathway, essential for the maintenance of genome stability. Members of the MutS and MutL protein families perform…”
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Eating well, living well and weight management: A co-produced semi-qualitative study of barriers and facilitators experienced by adults with intellectual disabilities by Doherty, AJ, Jones, SP, Chauhan, U, Gibson, JME

“…Adults with intellectual disabilities in England experience health inequalities. They are more likely than their non-disabled peers to be obese and at risk of…”
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Breast-feeding and risk of epithelial ovarian cancer by Jordan, S. J., Cushing-Haugen, K. L., Wicklund, K. G., Doherty, J. A., Rossing, M. A.

“…Purpose: Evidence suggests that breast-feeding may decrease the risk of epithelial ovarian cancer but it is not clear whether there is a relationship with…”
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Structural and mechanistic conservation in DNA ligases by Doherty, A J, Suh, S W

“…DNA ligases are enzymes required for the repair, replication and recombination of DNA. DNA ligases catalyse the formation of phosphodiester bonds at…”
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Septic Shock Attributed to Candida Infection: Importance of Empiric Therapy and Source Control by Kollef, Marin, Micek, Scott, Hampton, Nicholas, Doherty, Joshua A., Kumar, Anand

“…Background. Delayed treatment of candidemia has previously been shown to be an important determinant of patient outcome. However, septic shock attributed to…”
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Improved Performance of Monopiles When Combined with Footings for Tower Foundations in Sand by Lehane, B. M, Pedram, B, Doherty, J. A, Powrie, W

“…AbstractThis paper presents the results from a series of centrifuge tests and three-dimensional finite-element (FE) analyses, which examined the benefits of…”
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Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient by Riballo, E., Critchlow, S.E., Teo, S-H., Doherty, A.J., Priestley, A., Broughton, B., Kysela, B., Beamish, H., Plowman, N., Arlett, C.F., Lehmann, A.R., Jackson, S.P., Jeggo, P.A.

“…The major mechanism for the repair of DNA double-strand breaks (DSBs) in mammalian cells is non-homologous end-joining (NHEJ), a process that involves the…”
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The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity by Fitzjohn, S.M, Bortolotto, Z.A, Palmer, M.J, Doherty, A.J, Ornstein, P.L, Schoepp, D.D, Kingston, A.E, Lodge, D, Collingridge, G.L

“…Understanding the roles of metabotropic glutamate (mGlu) receptors has been severely hampered by the lack of potent antagonists. LY341495 (2 S-2-amino-2-(1 S,2…”
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A novel, competitive mGlu5 receptor antagonist (LY344545) blocks DHPG‐induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices by Doherty, A J, Palmer, M J, Bortolotto, Z A, Hargreaves, A, Kingston, A E, Ornstein, P L, Schoepp, D D, Lodge, D, Collingridge, G L

“…We have investigated the pharmacological properties of LY344545, a structurally related epimer of the broad spectrum competitive metabotropic glutamate…”
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Tagging single-nucleotide polymorphisms in candidate oncogenes and susceptibility to ovarian cancer by QUAYE, L, SONG, H, WOZNIAK, E, DOHERTY, J. A, ROSSING, M. A, NESS, R. B, MOYSICH, K. B, HØGDALL, C, BLAAKAER, J, EASTON, D. F, PONDER, Baj, JACOBS, I. J, RAMUS, S. J, MENON, U, WHITTEMORE, A. S, KRÜGER-KJAER, S, PEARCE, C. L, PHAROAH, Pdp, GAYTHER, S. A, GENTRY-MAHARAJ, A, HØGDALL, E, DICIOCCIO, R. A, MCGUIRE, V, WU, A. H, VAN DEN BERG, D. J, PIKE, M. C

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Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium by Pearce, C L, Near, A M, Van Den Berg, D J, Ramus, S J, Gentry-Maharaj, A, Menon, U, Gayther, S A, Anderson, A R, Edlund, C K, Wu, A H, Chen, X, Beesley, J, Webb, P M, Holt, S K, Chen, C, Doherty, J A, Rossing, M A, Whittemore, A S, McGuire, V, DiCioccio, R A, Goodman, M T, Lurie, G, Carney, M E, Wilkens, L R, Ness, R B, Moysich, K B, Edwards, R, Jennison, E, Kjaer, S K, Hogdall, E, Hogdall, C K, Goode, E L, Sellers, T A, Vierkant, R A, Cunningham, J C, Schildkraut, J M, Berchuck, A, Moorman, P G, Iversen, E S, Cramer, D W, Terry, K L, Vitonis, A F, Titus-Ernstoff, L, Song, H, Pharoah, P D P, Spurdle, A B, Anton-Culver, H, Ziogas, A, Brewster, W, Galitovskiy, V, Chenevix-Trench, G

“…The search for genetic variants associated with ovarian cancer risk has focused on pathways including sex steroid hormones, DNA repair, and cell cycle control…”
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Conversion of a DNA ligase into an RNA capping enzyme by Doherty, A J

“…In eukaryotes, newly synthesised mRNA is ‘capped’ by the addition of GMP to the 5′ end by RNA capping enzymes. Recent structural studies have shown that RNA…”
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Cohorting of infants with respiratory syncytial virus by Doherty, J.A., Brookfield, D.S.K., Gray, J., McEwan, R.A.

“…During two winter periods (1994–1995 and 1995–1996), nasopharyngeal aspirates were obtained from infants and young children with an acute respiratory illness,…”
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(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus by DOHERTY, A. J, PALMER, M. J, HENLEY, J. M, COLLINGRIDGE, G. L, JANE, D. E

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Antagonist activity of α‐substituted 4‐carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells by Doherty, A J, Collingridge, G L, Jane, D E

“…We have investigated the antagonist properties of 6 α‐substituted phenylglycine analogues based on the structure of 4‐carboxyphenylglycine (4‐CPG) for group I…”
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A Heterotrimeric PCNA in the Hyperthermophilic Archaeon Sulfolobus solfataricus by Dionne, Isabelle, Nookala, Ravi K, Jackson, Stephen P, Doherty, Aidan J, Bell, Stephen D

“…The sliding clamp, PCNA, of the archaeon Sulfolobus solfataricus P2 is a heterotrimer of three distinct subunits (PCNA1, 2, and 3) that assembles in a defined…”
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Final report and recommendations from the National Notifiable Diseases Working Group by Doherty, J A

“…The National Notifiable Diseases Working Group performed a ranking of 48 communicable diseases to assist with determining priorities for national surveillance…”
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Identification of a DNA Nonhomologous End-Joining Complex in Bacteria by Weller, Geoffrey R., Kysela, Boris, Roy, Rajat, Tonkin, Louise M., Scanlan, Elizabeth, Della, Marina, Devine, Susanne Krogh, Day, Jonathan P., Wilkinson, Adam, Fabrizio d'Adda di Fagagna, Devine, Kevin M., Bowater, Richard P., Jeggo, Penny A., Jackson, Stephen P., Doherty, Aidan J.

“…In eukaryotic cells, double-strand breaks (DSBs) in DNA are generally repaired by the pathway of homologous recombination or by DNA nonhomologous end joining…”
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Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor by Derbyshire, Dean J., Basu, Balaku P., Serpell, Louise C., Joo, Woo S., Date, Takayasu, Iwabuchi, Kuniyoshi, Doherty, Aidan J.

“…The BRCT (BRCA1 C‐terminus) is an evolutionary conserved protein–protein interacting module found as single, tandem or multiple repeats in a diverse range of…”
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DNA repair: How Ku makes ends meet by Doherty, Aidan J., Jackson, Stephen P.

“…The recently determined crystal structure of the Ku heterodimer, in both DNA-bound and unbound forms, has shed new light on the mechanism by which this protein…”
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