Search Results - "Doherty, Edward j."
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Combined delivery of VEGF and IGF-1 promotes functional innervation in mice and improves muscle transplantation in rabbits
Published in Biomaterials (01-09-2019)“…Microvascular muscle transfer is the gold standard for reanimation following chronic facial nerve paralysis, however, despite the regenerative capacity of…”
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Sclerostin antibody stimulates periodontal regeneration in large alveolar bone defects
Published in Scientific reports (01-10-2020)“…Destruction of the alveolar bone in the jaws can occur due to periodontitis, trauma or following tumor resection. Common reconstructive therapy can include the…”
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Single‐Shot Mesoporous Silica Rods Scaffold for Induction of Humoral Responses Against Small Antigens
Published in Advanced functional materials (01-09-2020)“…Vaccines have shown significant promise in eliciting protective and therapeutic responses. However, most effective vaccines require several booster shots, and…”
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Scaffold Vaccines for Generating Robust and Tunable Antibody Responses
Published in Advanced functional materials (01-04-2022)“…Traditional bolus vaccines often fail to sustain robust adaptive immune responses, typically requiring multiple booster shots for optimal efficacy…”
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Human TUBB3 Mutations Perturb Microtubule Dynamics, Kinesin Interactions, and Axon Guidance
Published in Cell (08-01-2010)“…We report that eight heterozygous missense mutations in TUBB3, encoding the neuron-specific β-tubulin isotype III, result in a spectrum of human nervous system…”
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Biomaterial vaccines capturing pathogen-associated molecular patterns protect against bacterial infections and septic shock
Published in Nature biomedical engineering (01-01-2022)“…Most bacterial vaccines work for a subset of bacterial strains or require the modification of the antigen or isolation of the pathogen before vaccine…”
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VEGF and IGF Delivered from Alginate Hydrogels Promote Stable Perfusion Recovery in Ischemic Hind Limbs of Aged Mice and Young Rabbits
Published in Journal of vascular research (01-01-2017)“…Biomaterial-based delivery of angiogenic growth factors restores perfusion more effectively than bolus delivery methods in rodent models of peripheral vascular…”
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A Modular Biomaterial Scaffold‐Based Vaccine Elicits Durable Adaptive Immunity to Subunit SARS‐CoV‐2 Antigens
Published in Advanced healthcare materials (01-11-2021)“…The coronavirus disease 2019 (COVID‐19) pandemic demonstrates the importance of generating safe and efficacious vaccines that can be rapidly deployed against…”
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Transport characterization of membranes for immunoisolation
Published in Biomaterials (1996)“…This study relates to the diffusive transport characterization of hollow fibre membranes used in implantable bio-hybrid organs and other immunoisolatory…”
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CFEOM3: A New Extraocular Congenital Fibrosis Syndrome that Maps to 16q24.2-q24.3
Published in Investigative ophthalmology & visual science (01-07-1999)“…To define the clinical characteristics and determine the gene localization for a previously undescribed form of congenital fibrosis of the extraocular muscles…”
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Protection of encapsulated human islets implanted without immunosuppression in patients with type I or type II diabetes and in nondiabetic control subjects
Published in Diabetes (New York, N.Y.) (01-09-1994)“…Human islets were macroencapsulated in permselective hollow fiber membrane devices and successfully allotransplanted subcutaneously with > 90% viability after…”
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Delivery of Neurotrophic Factors to the CNS Using Encapsulated Cells: Developing Treatments for Neurodegenerative Diseases
Published in Cell transplantation (01-01-1995)Get full text
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The Making of a Contract for Education Reform
Published in Phi Delta Kappan (01-06-1990)“…On May 22, 1989 the city of Boston MA and the Boston Teachers Union entered into a landmark agreement on education reform. The contract establishes a school…”
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Polymer science for macroencapsulation of cells for central nervous system transplantation
Published in Reactive polymers (1995)“…The goal of encapsulated cell therapy research is to develop implants containing living xenogeneic cells to treat serious and disabling human conditions. The…”
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Union President Champions Schools in Boston Mayoral Race
Published in Education week (12-06-1991)“…In the midst of a highly charged political fight over abolishing the Boston School Committee and continuing concerns over the city's school-desegregation case,…”
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Source Material on Meteorology (Book Review)
Published in College and Research Libraries (01-07-1950)Get full text
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Meteorological Abstracts and Bibliography, Vol. 1, no. 1 (Book Review)
Published in College & Research Libraries (30-06-1950)Get full text
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The Making of a Contract for Education Reform
Published in Phi Delta Kappan (1990)“…Describes Boston's efforts to abandon adversarial bargaining in favor of a reform-oriented contract establishing a shared decision-making model of school-based…”
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