Search Results - "Dohai, Bushra"
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High-Throughput Metabolic Profiling for Model Refinements of Microalgae
Published in Journal of visualized experiments (04-12-2021)“…Metabolic models are reconstructed based on an organism's available genome annotation and provide predictive tools to study metabolic processes at a…”
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Adaptive Evolution Signatures in Prochlorococcus : Open Reading Frame (ORF)eome Resources and Insights from Comparative Genomics
Published in Microorganisms (Basel) (20-08-2024)“…, a cyanobacteria genus of the smallest and most abundant oceanic phototrophs, encompasses ecotype strains adapted to high-light (HL) and low-light (LL)…”
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GPCR Genes as Activators of Surface Colonization Pathways in a Model Marine Diatom
Published in iScience (21-08-2020)“…Surface colonization allows diatoms, a dominant group of phytoplankton in oceans, to adapt to harsh marine environments while mediating biofoulings to…”
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Protocol to generate and characterize biofouling transformants of a model marine diatom
Published in STAR protocols (17-09-2021)“…Diatoms are a major group of microalgae that initiate biofouling by surface colonization of human-made underwater structures; however, the involved regulatory…”
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Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells
Published in Science advances (07-05-2021)“…The endoplasmic reticulum (ER) is a central eukaryotic organelle with a tubular network made of hairpin proteins linked by hydrolysis of guanosine triphosphate…”
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Microalgal Metabolic Network Model Refinement through High-Throughput Functional Metabolic Profiling
Published in Frontiers in bioengineering and biotechnology (10-12-2014)“…Metabolic modeling provides the means to define metabolic processes at a systems level; however, genome-scale metabolic models often remain incomplete in their…”
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Large-scale genome sequencing reveals the driving forces of viruses in microalgal evolution
Published in Cell host & microbe (10-02-2021)“…Being integral primary producers in diverse ecosystems, microalgal genomes could be mined for ecological insights, but representative genome sequences are…”
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SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-κB activation
Published in Bioscience reports (31-01-2024)“…Upon SARS-CoV-2 infection, patients with severe forms of COVID-19 often suffer from a dysregulated immune response and hyperinflammation. Aberrant expression…”
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Exploiting breakdown in nonhost effector-target interactions to boost host disease resistance
Published in Proceedings of the National Academy of Sciences - PNAS (30-08-2022)“…Plants are resistant to most microbial species due to nonhost resistance (NHR), providing broad-spectrum and durable immunity. However, the molecular…”
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A proteome-scale map of the SARS-CoV-2–human contactome
Published in Nature biotechnology (01-01-2023)“…Understanding the mechanisms of coronavirus disease 2019 (COVID-19) disease severity to efficiently design therapies for emerging virus variants remains an…”
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Systems level analysis of the Chlamydomonas reinhardtii metabolic network reveals variability in evolutionary co-conservation
Published in Molecular bioSystems (01-01-2016)“…Metabolic networks, which are mathematical representations of organismal metabolism, are reconstructed to provide computational platforms to guide metabolic…”
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