Radioprotective Potential of an Herbal Extract of Tinospora cordifolia

A preparation of Tinospora cordifolia (RTc) administered i. p. (200 mg/kg b.w.) to strain "A" male mice 1 h before whole body gamma-irradiation was evaluated for its radioprotective efficacy in terms of whole body survival, spleen colony forming units (CFU), hematological parameters, cell...

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Published in:	JOURNAL OF RADIATION RESEARCH Vol. 45; no. 1; pp. 61 - 68
Main Authors:	Goel, Harish Chandra, Prasad, Jagadish, Singh, Surinder, Sagar, Ravinder Kumar, Agrawala, Paban Kumar, Bala, Madhu, Sinha, Arun Kumar, Dogra, Ruchi
Format:	Journal Article
Language:	English
Published:	England THE JAPAN RADIATION RESEARCH SOCIETY 2004 Oxford University Press
Subjects:	Animals Body Weight - drug effects Body Weight - radiation effects Bone Marrow Cells - drug effects Bone Marrow Cells - pathology Bone Marrow Cells - radiation effects Dose-Response Relationship, Drug Hemoglobins - analysis Lethal Dose 50 Leukocyte Count Male Mice Phytotherapy - methods Plant Extracts - therapeutic use Plant Extracts - toxicity Radiation Injuries - prevention & control Radiation Tolerance - drug effects Radiation-Protective Agents - therapeutic use Radiation-Protective Agents - toxicity Survival Survival Analysis Tinospora - metabolism
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Summary:	A preparation of Tinospora cordifolia (RTc) administered i. p. (200 mg/kg b.w.) to strain "A" male mice 1 h before whole body gamma-irradiation was evaluated for its radioprotective efficacy in terms of whole body survival, spleen colony forming units (CFU), hematological parameters, cell cycle progression, and micronuclei induction. Preirradiation treatment with RTc rendered 76.3% survival (30 days), compared to 100% mortality in irradiated control and prevented radiation induced weight loss. On 10th postirradiation day, the endogenous CFU counts in spleen were decreased with increasing radiation doses 12.0 (5 Gy), 2. 16 (7.5 Gy) and 0.33 (10 Gy) but pre-irradiation administration of 200 mg/kg b.w. of RTc increased CFU counts to 31.16, 21.83 and 3.00 respectively. Pre-irradiation RTc treatment could restore total lymphocyte counts (TLC) by the 15th day to normal. It also increased the S-phase cell population that was reduced following 2 Gy irradiation in a time dependent manner. 2 Gy irradiation-induced micronuclei were also decreased by a pre-irradiation administration of RTc from 2.9 to 0.52%. Because the radioprotective manifestation of RTc observed in several systems in experimental animals can be exploited for human applications.
ISSN:	0449-3060 1349-9157
DOI:	10.1269/jrr.45.61