Stabilization and controlled release of micro‐encapsulated hydrogen peroxide for wound treatment applications

Stabilization and controlled release of micro‐encapsulated hydrogen peroxide for wound treatment applications

Aims Hydrogen peroxide (H2O2) disinfection applications are limited by its rapid inactivation. The aims of this study were to (i) micro‐encapsulate H2O2 in silica hydrogels to obtain controlled release up to 72 h, (ii) test hydrogel antimicrobial activity against four common pathogens and (iii) asse...

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Bibliographic Details
Published in:Journal of applied microbiology Vol. 126; no. 3; pp. 965 - 972
Main Authors: Dogan‐Guner, E.M., Mohamed, H., Orbey, N., Goodyear, N.
Format: Journal Article
Language:English
Published: England Oxford University Press 01-03-2019
Subjects:
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Approximation
Controlled release
Deactivation
Disinfection
E coli
Encapsulation
Hydrogels
Hydrogen peroxide
Inactivation
Kinetics
Lumens
Medical equipment
Medical instruments
Medical materials
micro‐encapsulation
Pore size
Porosity
Relative humidity
Scanning electron microscopy
Silica
Silicon dioxide
Statistical analysis
topical antisepsis
Vancomycin
Wound healing
Wounds
micro-encapsulation
topical antisepsis
controlled release
wound healing
antimicrobial activity
hydrogen peroxide
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Summary:Aims Hydrogen peroxide (H2O2) disinfection applications are limited by its rapid inactivation. The aims of this study were to (i) micro‐encapsulate H2O2 in silica hydrogels to obtain controlled release up to 72 h, (ii) test hydrogel antimicrobial activity against four common pathogens and (iii) assess H2O2 release kinetics and antimicrobial activity in 35–65% relative humidity and 37°C to approximate bandaged wound conditions. Methods and Results Hydrogels were characterized using scanning electron microscopy, nitrogen sorption porosimetry, Brunauer Emmet Teller analysis and the Barret–Joyner–Halenda method. Hydrogels formed at lower pH demonstrated increased surface area and decreased pore size, resulting in H2O2 release lasting 72 h. Using agar well diffusion for antimicrobial activity, statistically significant zones of inhibition (as compared to controls) were seen for Escherichia coli, Staphylococcus aureus, Pseudomona aeruginiosa and Vancomycin‐resistant Enterococcus faecalis. Activity remained for hydrogels aged for 72 h in humid, 37°C conditions. Conclusions Hydrogels can be synthesized to provide a continuous, controlled release of H2O2 for up to 72 h. Significance and Impact of the Study Stable, controlled‐release H2O2 hydrogels have potential applications for wound treatment and disinfection of medical equipment, through bonding to bandages or materials such as catheter lumens.
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ISSN:1364-5072
1365-2672
DOI:10.1111/jam.14177