Search Results - "Doetsch, P. W."

Understanding Cancer Development Processes after HZE-Particle Exposure: Roles of ROS, DNA Damage Repair and Inflammation by Sridharan, D. M., Asaithamby, A., Bailey, S. M., Costes, S. V., Doetsch, P. W., Dynan, W. S., Kronenberg, A., Rithidech, K. N., Saha, J., Snijders, A. M., Werner, E., Wiese, C., Cucinotta, F. A., Pluth, J. M.

“…During space travel astronauts are exposed to a variety of radiations, including galactic cosmic rays composed of high-energy protons and high-energy charged…”
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Effects of Abasic Sites and DNA Single-Strand Breaks on Prokaryotic RNA Polymerases by Zhou, Wei, Doetsch, Paul W.

“…Abasic sites are thought to be the most frequently occurring cellular DNA damage and are generated spontaneously or as the result of chemical or radiation…”
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Phenotypic Change Caused by Transcriptional Bypass of Uracil in Nondividing Cells by Viswanathan, Anand, You, Ho Jin, Doetsch, Paul W.

“…Cytosine deamination to uracil occurs frequently in cellular DNA. In vitro, RNA polymerase efficiently inserts adenine opposite to uracil, resulting in G to A…”
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Drosophila ribosomal protein contains 8-oxoguanine and abasic site DNA repair activities by Yacoub, A, Augeri, L, Kelley, M.R, Doetsch, P.W, Deutsch, W.A

“…Ionizing radiation and normal cellular respiration form reactive oxygen species that damage DNA and contribute to a variety of human disorders including tumor…”
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Substrate specificities of the Ntg1 and Ntg2 proteins of Saccharomyces cerevisiae for oxidized DNA bases are not identical by Senturker, S, Kemp, P.A. van der, You, H.J, Doetsch, P.W, Dizdaroglu, M, Boiteux, S

“…Two genes of Saccharomyces cerevisiae, NTG1 and NTG2, encode proteins with a significant sequence homology to the endonuclease III of Escherichia coli. The…”
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Substrate specificity of ultraviolet DNA endonuclease (UVDE/Uve1p) from Schizosaccharomyces pombe by Avery, A.M, Kaur, B, Taylor, J.S, Mello, J.A, Essigmann, J.M, Doetsch, P.W

“…Schizosaccharomyces pombe ultraviolet DNA endonuclease (UVDE or Uve1p) has been shown to cleave 5′ to UV light-induced cyclobutane pyrimidine dimers (CPDs) and…”
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Characterization of Schizosaccharomyces pombe Rad2 protein, a FEN-1 homolog by Alleva, J.L, Doetsch, P.W

“…FEN-1 proteins are a family of nucleases essential for lagging strand DNA synthesis. A gene with sequence similarity to FEN-1 protein-encoding genes, rad2+,…”
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Escherichia coli RNA and DNA polymerase bypass of dihydrouracil: Mutagenic potential via transcription and replication by Liu, Jiang, Doetsch, Paul W.

“…Dihydrouracil (DHU) is a DNA base damage product produced in significant amounts by ionizing radiation damage to cytosine under anoxic conditions. DHU…”
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E. coli RNA Polymerase Bypass of DNA Base Damage: Mutagenesis at the Level of Transcription by VISWANATHAN, A., LIU, J., DOETSCH, P. W.

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Transcriptional Mutagenesis Induced by Uracil and 8-Oxoguanine in Escherichia coli by Brégeon, Damien, Doddridge, Zara A, You, Ho Jin, Weiss, Bernard, Doetsch, Paul W

“…Cells exposed to DNA damaging agents in their natural environment do not undergo continuous cycles of replication but are more frequently engaged in gene…”
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new ATP-independent DNA endonuclease from Schizosaccharomyces pombe that recognizes cyclobutane pyrimidine dimers and 6-4 photoproducts by Bowman, K.K, Sidik, K, Smith, C.A, Taylor, J.S, Doetsch, P.W, Freyer, G.A

“…We have discovered a new DNA endonuclease in the fission yeast Schizosaccharomyces pombe which recognizes cyclobutane pyrimidine dimers and (6-4)…”
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An alternative eukaryotic DNA excision repair pathway by Freyer, Greg A., Davey, Scott, Ferrer, Jasmine V., Martin, Amy M., Beach, David, Doetsch, Paul W.

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RNA polymerase bypass at sites of dihydrouracil: implications for transcriptional mutagenesis by Liu, Jiang, Zhou, Wei, Doetsch, Paul W.

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DNA binding properties of YB-1 and dbpA : binding to double-stranded, single-stranded, and abasic site containing DNAs by HASEGAWA, S. L, DOETSCH, P. W, HAMILTON, H. K, MARTIN, A. M, OKENQUIST, S. A, LENZ, J, BOSS, J. M

“…A number of eukaryotic DNA binding proteins have been isolated by screening phage expression libraries with DNA probes containing the binding site of the…”
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A highly conserved endonuclease activity present in Escherichia coli, bovine, and human cells recognizes oxidative DNA damage at sites of pyrimidines by DOETSCH, P. W, HENNER, W. D, CUNNINGHAM, R. P, TONEY, J. H, HELLAND, D. E

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Overlapping Specificities of Base Excision Repair, Nucleotide Excision Repair, Recombination, and Translesion Synthesis Pathways for DNA Base Damage in Saccharomyces cerevisiae by Swanson, Rebecca L., Morey, Natalie J., Doetsch, Paul W., Jinks-Robertson, Sue

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Base Excision Repair of Oxidative DNA Damage Activated by XPG Protein by Klungland, Arne, Höss, Matthias, Gunz, Daniela, Constantinou, Angelos, Clarkson, Stuart G, Doetsch, Paul W, Bolton, Philip H, Wood, Richard D, Lindahl, Tomas

“…Oxidized pyrimidines in DNA are removed by a distinct base excision repair pathway initiated by the DNA glycosylase—AP lyase hNth1 in human cells. We have…”
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Mitochondrial Dysfunction Due to Oxidative Mitochondrial DNA Damage Is Reduced through Cooperative Actions of Diverse Proteins by O'Rourke, Thomas W., Doudican, Nicole A., Mackereth, Melinda D., Doetsch, Paul W., Shadel, Gerald S.

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Substrate specificity of a mammalian DNA repair endonuclease that recognizes oxidative base damage by HELLAND, D. E, DOETSCH, P. W, HASELTINE, W. A

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Spontaneous DNA Damage in Saccharomyces cerevisiae Elicits Phenotypic Properties Similar to Cancer Cells by Evert, Barbara A, Salmon, Tiffany B, Song, Binwei, Jingjing, Liu, Siede, Wolfram, Doetsch, Paul W

“…To determine the spectrum of effects elicited by specific levels of spontaneous DNA damage, a series of isogenic Saccharomyces cerevisiae strains defective in…”
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