Search Results - "Doeselaar, Marina"

Notochordal Cell Matrix As a Therapeutic Agent for Intervertebral Disc Regeneration by de Vries, Stefan, Doeselaar, Marina van, Meij, Björn, Tryfonidou, Marianna, Ito, Keita

“…Notochordal cells (NCs) reside in the core of the healthy disc and produce soluble factors that can stimulate nucleus pulposus cells (NPCs). These NC-derived…”
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Neo‐cartilage formation using human nondegenerate versus osteoarthritic chondrocyte‐derived cartilage organoids in a viscoelastic hydrogel by Kleuskens, Meike W. A., Crispim, João F., Doeselaar, Marina, Donkelaar, Corrinus C., Janssen, Rob P. A., Ito, Keita

“…Current regenerative cartilage therapies are associated with several drawbacks such as dedifferentiation of chondrocytes during expansion and the formation of…”
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Macrophage-Driven Biomaterial Degradation Depends on Scaffold Microarchitecture by Wissing, Tamar B, Bonito, Valentina, van Haaften, Eline E, van Doeselaar, Marina, Brugmans, Marieke M C P, Janssen, Henk M, Bouten, Carlijn V C, Smits, Anthal I P M

“…tissue engineering is a technology in which non-cellular biomaterial scaffolds are implanted in order to induce local regeneration of replaced or damaged…”
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Comparison of annulus fibrosus cell collagen remodeling rates in a microtissue system by Tromp, Isabel N., Foolen, Jasper, Doeselaar, Marina, Zhang, Ying, Chan, Danny, Kruyt, Moyo C., Creemers, Laura B., Castelein, Rene M., Ito, Keita

“…It has been suggested that curvature progression in adolescent idiopathic scoliosis occurs through irreversible changes in the intervertebral discs. Strains of…”
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Conditioned medium derived from notochordal cell-rich nucleus pulposus tissue stimulates matrix production by canine nucleus pulposus cells and bone marrow-derived stromal cells by de Vries, Stefan A H, Potier, Esther, van Doeselaar, Marina, Meij, Björn P, Tryfonidou, Marianna A, Ito, Keita

“…Conditioned medium derived from notochordal cell-rich nucleus pulposus tissue (NCCM) was previously shown to have a stimulatory effect on bone marrow stromal…”
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Semi-synthetic degradable notochordal cell-derived matrix hydrogel for use in degenerated intervertebral discs: Initial in vitro characterization by Schmitz, Tara C, van Genabeek, Bas, Pouderoijen, Maarten J, Janssen, Henk M, van Doeselaar, Marina, Crispim, João F, Tryfonidou, Marianna A, Ito, Keita

“…Low back pain is the leading cause of disability worldwide, but current therapeutic interventions are palliative or surgical in nature. Loss of notochordal…”
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Off-the-shelf human decellularized tissue-engineered heart valves in a non-human primate model by Weber, Benedikt, Dijkman, Petra E, Scherman, Jacques, Sanders, Bart, Emmert, Maximilian Y, Grünenfelder, Jürg, Verbeek, Renier, Bracher, Mona, Black, Melanie, Franz, Thomas, Kortsmit, Jeroen, Modregger, Peter, Peter, Silvia, Stampanoni, Marco, Robert, Jérôme, Kehl, Debora, van Doeselaar, Marina, Schweiger, Martin, Brokopp, Chad E, Wälchli, Thomas, Falk, Volkmar, Zilla, Peter, Driessen-Mol, Anita, Baaijens, Frank P.T, Hoerstrup, Simon P

“…Abstract Heart valve tissue engineering based on decellularized xenogenic or allogenic starter matrices has shown promising first clinical results. However,…”
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Identifying potential patient-specific predictors for anterior cruciate ligament reconstruction outcome – a diagnostic in vitro tissue remodeling platform by van Vijven, Marc, van Groningen, Bart, Kimenai, Joyce N., van der Steen, Maria C., van Doeselaar, Marina, Janssen, Rob P. A., Ito, Keita, Foolen, Jasper

“…Purpose Upon anterior cruciate ligament (ACL) rupture, reconstruction is often required, with the hamstring tendon autograft as most widely used treatment…”
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Notochordal cell matrix: An inhibitor of neurite and blood vessel growth? by de Vries, Stefan A.H., van Doeselaar, Marina, Meij, Björn P., Tryfonidou, Marianna A., Ito, Keita

“…ABSTRACT Blood vessel and neurite ingrowth into the degenerating intervertebral disc (IVD) are related to pain. In reported studies, notochordal cell…”
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The LRRK2 Arg1628Pro variant is a risk factor for Parkinson’s disease in the Chinese population by Lu, Chin-Song, Wu-Chou, Yah-Huei, van Doeselaar, Marina, Simons, Erik J., Chang, Hsiu-Chen, Breedveld, Guido J., Di Fonzo, Alessio, Chen, Rou-Shayn, Weng, Yi-Hsin, Lai, Szu-Chia, Oostra, Ben A., Bonifati, Vincenzo

“…The c.G4883C variant in the leucine-rich repeat kinase 2 ( LRRK2 ) gene (protein effect: Arg1628Pro) has been recently proposed as a second risk factor for…”
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A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan by DI FONZO, Alessio, WU-CHOU, Yah-Huei, BREEDVELD, Guido J, OOSTRA, Ben A, BONIFATI, Vincenzo, LU, Chin-Song, VAN DOESELAAR, Marina, SIMONS, Erik J, ROHE, Christan F, CHANG, Hsiu-Chen, CHEN, Rou-Shayn, WENG, Yi-Hsin, VANACORE, Nicola

“…Mutations in the LRRK2 gene are a cause of autosomal dominant Parkinson's disease (PD). Whether LRRK2 variants influence susceptibility to the commoner,…”
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High prevalence of LRRK2 mutations in familial and sporadic Parkinson's disease in Portugal by Ferreira, Joaquim J., Guedes, Leonor Correia, Rosa, Mário Miguel, Coelho, Miguel, van Doeselaar, Marina, Schweiger, Dorothea, Di Fonzo, Alessio, Oostra, Ben A., Sampaio, Cristina, Bonifati, Vincenzo

“…Mutations in the Leucine‐Rich Repeat Kinase 2 (LRRK2) gene are the most frequent known cause of Parkinson's disease (PD), but their prevalence varies markedly…”
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Detergent-Free Decellularization of Notochordal Cell-Derived Matrix Yields a Regenerative, Injectable, and Swellable Biomaterial by Schmitz, Tara C., van Doeselaar, Marina, Tryfonidou, Marianna A., Ito, Keita

“…Porcine notochordal cell-derived matrix (NCM) has anti-inflammatory and regenerative effects on degenerated intervertebral discs. For its clinical use, safety…”
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The Stimulatory Effect of Notochordal Cell-Conditioned Medium in a Nucleus Pulposus Explant Culture by de Vries, Stefan A H, van Doeselaar, Marina, Meij, Björn P, Tryfonidou, Marianna A, Ito, Keita

“…Notochordal cell-conditioned medium (NCCM) has previously shown to have a stimulatory effect on nucleus pulposus cells (NPCs) and bone marrow stromal cells…”
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Potential application of notochordal cells for intervertebral disc regeneration: an in vitro assessment by Potier, E, de Vries, S, van Doeselaar, M, Ito, K

“…Recent studies suggest that notochordal cells (NCs) might be involved in intervertebral disc homeostasis, a role exploitable to counteract matrix degradation…”
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LRRK2 G2019S mutation and Parkinson's disease: A clinical, neuropsychological and neuropsychiatric study in a large Italian sample by Goldwurm, Stefano, Zini, Michela, Di Fonzo, Alessio, De Gaspari, Danilo, Siri, Chiara, Simons, Erik J., van Doeselaar, Marina, Tesei, Silvana, Antonini, Angelo, Canesi, Margherita, Zecchinelli, Anna, Mariani, Claudio, Meucci, Nicoletta, Sacilotto, Giorgio, Cilia, Roberto, Isaias, Ioannis U., Bonetti, A., Sironi, Francesca, Ricca, Sara, Oostra, Ben A., Bonifati, Vincenzo, Pezzoli, Gianni

“…We analysed the Leucine-Rich Repeat Kinase 2 ( LRRK2) gene for the G2019S mutation in 1245 consecutive, unrelated patients with primary degenerative…”
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Stimulatory Effect of Notochordal Cell-Conditioned Medium in a Nucleus Pulposus Explant Culture by de Vries, Stefan, van Doeselaar, Marina, Meij, Björn, Tryfonidou, Marianna, Ito, Keita

“…Introduction Notochordal cell-conditioned medium (NCCM) has shown to stimulate matrix production by nucleus pulposus cells (NPCs) in alginate bead cultures.1,2…”
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Polymorphisms in the genes involved in the arachidonic acid‐pathway, fish consumption and the risk of colorectal cancer by Siezen, Christine L.E., Bueno‐de‐Mesquita, H. Bas, Peeters, Petra H.M., Kram, Nicolien R., van Doeselaar, Marina, van Kranen, Henk J.

“…The objective of this study on colorectal cancer was to investigate the associations between SNPs in the genes involved in the arachidonic acid (AA)‐pathway,…”
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LRRK2 mutations and Parkinson's disease in Sardinia—A Mediterranean genetic isolate by Cossu, Giovanni, van Doeselaar, Marina, Deriu, Marcello, Melis, Maurizio, Molari, Andrea, Di Fonzo, Alessio, Oostra, Ben A, Bonifati, Vincenzo

“…Abstract The Leucine-Rich Repeat Kinase 2 ( LRRK2 ) Gly2019Ser mutation is frequent among Parkinson's disease (PD) patients from the Arab, Jewish, and Iberian…”
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The LRRK2 Argl628Pro variant is a risk factor for Parkinson's disease in the Chinese population by LU, Chin-Song, WU-CHOU, Yah-Huei, OOSTRA, Ben A, BONIFATI, Vincenzo, VAN DOESELAAR, Marina, SIMONS, Erik J, CHANG, Hsiu-Chen, BREEDVELD, Guido J, DI FONZO, Alessio, CHEN, Rou-Shayn, WENG, Yi-Hsin, LAI, Szu-Chia

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