Search Results - "Doerrer, Nancy G."

The use of mode of action information in risk assessment: Quantitative key events/dose-response framework for modeling the dose-response for key events by Simon, Ted W., Simons, S. Stoney, Preston, R. Julian, Boobis, Alan R., Cohen, Samuel M., Doerrer, Nancy G., Fenner-Crisp, Penelope A., McMullin, Tami S., McQueen, Charlene A., Rowlands, J. Craig

“…Abstract The HESI RISK21 project formed the Dose-Response/Mode-of-Action Subteam to develop strategies for using all available data (in vitro, in vivo, and in…”
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Hemangiosarcoma in Rodents: Mode-of-Action Evaluation and Human Relevance by Cohen, Samuel M., Storer, Richard D., Criswell, Kay A., Doerrer, Nancy G., Dellarco, Vicki L., Pegg, David G., Wojcinski, Zbigniew W., Malarkey, David E., Jacobs, Abigail C., Klaunig, James E., Swenberg, James A., Cook, Jon C.

“…Although rarely occurring in humans, hemangiosarcomas (HS) have become important in evaluating the potential human risk of several chemicals, including…”
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The Acquisition and Application of Absorption, Distribution, Metabolism, and Excretion (ADME) Data in Agricultural Chemical Safety Assessments by Barton, Hugh A., Pastoor, Timothy P., Baetcke, Karl, Chambers, Janice E., Diliberto, Janet, Doerrer, Nancy G., Driver, Jeffrey H., Hastings, Charles E., Iyengar, Seshadri, Krieger, Robert, Stahl, Bernhard, Timchalk, Charles

“…A proposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute…”
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A Data-Based Assessment of Alternative Strategies for Identification of Potential Human Cancer Hazards by Boobis, Alan R., Cohen, Samuel M., Doerrer, Nancy G., Galloway, Sheila M., Haley, Patrick J., Hard, Gordon C., Hess, Frederick G., Macdonald, James S., Thibault, Stéphane, Wolf, Douglas C., Wright, Jayne

“…The two-year cancer bioassay in rodents remains the primary testing strategy for in-life screening of compounds that might pose a potential cancer hazard. Yet…”
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FutureTox II: in vitro data and in silico models for predictive toxicology by Knudsen, Thomas B, Keller, Douglas A, Sander, Miriam, Carney, Edward W, Doerrer, Nancy G, Eaton, David L, Fitzpatrick, Suzanne Compton, Hastings, Kenneth L, Mendrick, Donna L, Tice, Raymond R, Watkins, Paul B, Whelan, Maurice

“…FutureTox II, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in January, 2014. The meeting goals were to review and discuss the…”
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Genetic basis and detection of unintended effects in genetically modified crop plants by Ladics, Gregory S., Bartholomaeus, Andrew, Bregitzer, Phil, Doerrer, Nancy G., Gray, Alan, Holzhauser, Thomas, Jordan, Mark, Keese, Paul, Kok, Esther, Macdonald, Phil, Parrott, Wayne, Privalle, Laura, Raybould, Alan, Rhee, Seung Yon, Rice, Elena, Romeis, Jörg, Vaughn, Justin, Wal, Jean-Michel, Glenn, Kevin

“…In January 2014, an international meeting sponsored by the International Life Sciences Institute/Health and Environmental Sciences Institute and the Canadian…”
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Risk assessment in the 21st century: Roadmap and matrix by Embry, Michelle R., Bachman, Ammie N., Bell, David R., Boobis, Alan R., Cohen, Samuel M., Dellarco, Michael, Dewhurst, Ian C., Doerrer, Nancy G., Hines, Ronald N., Moretto, Angelo, Pastoor, Timothy P., Phillips, Richard D., Rowlands, J. Craig, Tanir, Jennifer Y., Wolf, Douglas C., Doe, John E.

“…Abstract The RISK21 integrated evaluation strategy is a problem formulation-based exposure-driven risk assessment roadmap that takes advantage of existing…”
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A 21st century roadmap for human health risk assessment by Pastoor, Timothy P., Bachman, Ammie N., Bell, David R., Cohen, Samuel M., Dellarco, Michael, Dewhurst, Ian C., Doe, John E., Doerrer, Nancy G., Embry, Michelle R., Hines, Ronald N., Moretto, Angelo, Phillips, Richard D., Rowlands, J. Craig, Tanir, Jennifer Y., Wolf, Douglas C., Boobis, Alan R.

“…Abstract The Health and Environmental Sciences Institute (HESI)-coordinated Risk Assessment in the 21st Century (RISK21) project was initiated to develop a…”
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Strategic Biomonitoring Initiatives: Moving the Science Forward by Angerer, Jürgen, Bird, Michael G., Burke, Thomas A., Doerrer, Nancy G., Needham, Larry, Robison, Steven H., Sheldon, Linda, Zenick, Hal

“…Biomonitoring programs in the United States and Europe demonstrate the vast array of data that are publicly available for the evaluation of exposure trends,…”
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Use of the RISK21 roadmap and matrix: human health risk assessment of the use of a pyrethroid in bed netting by Doe, John E., Lander, Deborah R., Doerrer, Nancy G., Heard, Nina, Hines, Ronald N., Lowit, Anna B., Pastoor, Timothy, Phillips, Richard D., Sargent, Dana, Sherman, James H., Young Tanir, Jennifer, Embry, Michelle R.

“…The HESI-coordinated RISK21 roadmap and matrix are tools that provide a transparent method to compare exposure and toxicity information and assess whether…”
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Assessment of potential adjuvanticity of Cry proteins by Joshi, Saurabh S., Barnett, Brian, Doerrer, Nancy G., Glenn, Kevin, Herman, Rod A., Herouet-Guicheney, Corinne, Hunst, Penny, Kough, John, Ladics, Gregory S., McClain, Scott, Papineni, Sabitha, Poulsen, Lars K., Rascle, Jean-Baptiste, Tao, Ai-Lin, van Ree, Ronald, Ward, Jason, Bowman, Christal C.

“…Genetically modified (GM) crops have achieved success in the marketplace and their benefits extend beyond the overall increase in harvest yields to include…”
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A proposed framework for assessing risk from less-than-lifetime exposures to carcinogens by Felter, Susan P., Conolly, Rory B., Bercu, Joel P., Bolger, P. Michael, Boobis, Alan R., Bos, Peter M. J., Carthew, Philip, Doerrer, Nancy G., Goodman, Jay I., Harrouk, Wafa A., Kirkland, David J., Lau, Serrine S., Llewellyn, G. Craig, Preston, R. Julian, Schoeny, Rita, Schnatter, A. Robert, Tritscher, Angelika, van Velsen, Frans, Williams, Gary M.

“…Quantitative methods for estimation of cancer risk have been developed for daily, lifetime human exposures. There are a variety of studies or methodologies…”
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Dose-dependent transitions in mechanisms of toxicity: case studies by Slikker, William, Andersen, Melvin E., Bogdanffy, Matthew S., Bus, James S., Cohen, Steven D., Conolly, Rory B., David, Raymond M., Doerrer, Nancy G., Dorman, David C., Gaylor, David W., Hattis, Dale, Rogers, John M., Setzer, R. Woodrow, Swenberg, James A., Wallace, Kendall

“…Experience with dose response and mechanisms of toxicity has shown that multiple mechanisms may exist for a single agent along the continuum of the full…”
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Dose-dependent transitions in mechanisms of toxicity by Slikker, William, Andersen, Melvin E., Bogdanffy, Matthew S., Bus, James S., Cohen, Steven D., Conolly, Rory B., David, Raymond M., Doerrer, Nancy G., Dorman, David C., Gaylor, David W., Hattis, Dale, Rogers, John M., Woodrow Setzer, R., Swenberg, James A., Wallace, Kendall

“…Scientists and decision makers from all sectors agree that risk assessments should be based on the best available science. Several years ago, the Health and…”
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Integration of human biomonitoring exposure data into risk assessment: HESI initiatives and perspectives by Doerrer, Nancy G.

“…The International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) established a Biomonitoring Technical Committee in 2002 to…”
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A Tiered Approach to Life Stages Testing for Agricultural Chemical Safety Assessment by Cooper, Ralph L., Lamb, James C., Barlow, Sue M., Bentley, Karin, Brady, Angela M., Doerrer, Nancy G., Eisenbrandt, David L., Fenner-Crisp, Penelope A., Hines, Ronald N., Irvine, Lorraine F. H., Kimmel, Carole A., Koeter, Herman, Li, Abby A., Makris, Susan L., Sheets, Larry P., Speijers, Gerrit J. A., Whitby, Karen E.

“…Aproposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute…”
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Identification and characterization of adverse effects in 21st century toxicology by Keller, Douglas A, Juberg, Daland R, Catlin, Natasha, Farland, William H, Hess, Frederick G, Wolf, Douglas C, Doerrer, Nancy G

“…The practice of toxicology is changing rapidly, as demonstrated by the response to the 2007 NRC report on "Toxicity Testing in the 21(st) Century." New assays…”
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A Tiered Approach to Systemic Toxicity Testing for Agricultural Chemical Safety Assessment by Doe, John E., Boobis, Alan R., Blacker, Ann, Dellarco, Vicki, Doerrer, Nancy G., Franklin, Claire, Goodman, Jay I., Kronenberg, Joel M., Lewis, Richard, McConnell, Ernest E., Mercier, Thierry, Moretto, Angelo, Nolan, Canice, Padilla, Stephanie, Phang, Whang, Solecki, Roland, Tilbury, Lorraine, van Ravenzwaay, Bennard, Wolf, Douglas C.

“…Aproposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute…”
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Sensitizing properties of proteins: executive summary by Poulsen, Lars K, Ladics, Gregory S, McClain, Scott, Doerrer, Nancy G, Ree, Ronald

“…The scope of allergy risk is diverse considering the myriad ways in which protein allergenicity is affected by physiochemical characteristics of proteins. The…”
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Human and environmental health challenges for the next decade (2010-2020) by Bonnefoi, Marc S., Belanger, Scott E., Devlin, Dennis J., Doerrer, Nancy G., Embry, Michelle R., Fukushima, Shoji, Harpur, Ernest S., Hines, Ronald N., Holsapple, Michael P., Kim, James H., MacDonald, James S., O'Lone, Raegan, Pettit, Syril D., Stevens, James L., Takei, Ayako S., Tinkle, Sally S., van der Laan, Jan Willem

“…The public health and environmental communities will face many challenges during the next decade. To identify significant issues that might be addressed as…”
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