Search Results - "Doering, Karen A"

An investigation of plasma cell-free RNA for the detection of colorectal cancer: From transcriptome marker selection to targeted validation by Northrop-Albrecht, Emmalee J, Wu, Chung Wah, Berger, Calise K, Taylor, William R, Foote, Patrick H, Doering, Karen A, Gonser, Anna M, Bhagwate, Aditya, Sun, Zhifu, Mahoney, Douglas W, Burger, Kelli N, Boardman, Lisa A, Kisiel, John B

“…Regular screening for colorectal cancer (CRC) is critical for early detection and long-term survival. Despite the current screening options available and…”
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Novel Methylated DNA Markers in the Surveillance of Colorectal Cancer Recurrence by Xie, Hao, Mahoney, Douglas W, Foote, Patrick H, Burger, Kelli N, Doering, Karen A, Taylor, William R, Then, Sara S, Cao, Xiaoming, McGlinch, Maria, Berger, Calise K, Wu, Tsung-Teh, Hubbard, Joleen M, Allawi, Hatim T, Kaiser, Michael W, Lidgard, Graham P, Ahlquist, David A, Kisiel, John B

“…We aimed to assess the concordance of colorectal cancer-associated methylated DNA markers (MDM) in primary and metastatic colorectal cancer for feasibility in…”
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Methylated DNA Markers in Voided Urine for the Identification of Clinically Significant Prostate Cancer by Shah, Paras, Taylor, William R, Negaard, Brianna J, Gochanour, Benjamin R, Mahoney, Douglas W, Then, Sara S, Devens, Mary E, Foote, Patrick H, Doering, Karen A, Burger, Kelli N, Nikolai, Brandon, Kaiser, Michael W, Allawi, Hatim T, Cheville, John C, Kisiel, John B, Gettman, Matthew T

“…Non-invasive assays are needed to better discriminate patients with prostate cancer (PCa) to avoid over-treatment of indolent disease. We analyzed 14…”
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Discovery and Validation of Methylated DNA Markers From Pancreatic Neuroendocrine Tumors by Majumder, Shounak, Halfdanarson, Thorvardur R., Berger, Calise K., Foote, Patrick H., Cao, Xiaoming, McGlinch, Maria C., Gysbers, Brianna J., de La Fuente, Jaime, Robran, Mariah J., Doering, Karen A., Burger, Kelli N., Bamlet, William E., Oberg, Ann L., Mahoney, Douglas W., Graham, Rondell P., Taylor, William R., Petersen, Gloria M., Kisiel, John B.

“…Methylated DNA markers (MDMs) accurately identify several different cancer types, but there are limited data for pancreatic neuroendocrine tumors (pNETs). We…”
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High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9 by Majumder, Shounak, Taylor, William R, Foote, Patrick H, Berger, Calise K, Wu, Chung Wah, Mahoney, Douglas W, Bamlet, William R, Burger, Kelli N, Postier, Neil, de la Fuente, Jaime, Doering, Karen A, Lidgard, Graham P, Allawi, Hatim T, Petersen, Gloria M, Chari, Suresh T, Ahlquist, David A, Kisiel, John B

“…We have previously identified tissue methylated DNA markers (MDMs) associated with pancreatic ductal adenocarcinoma (PDAC). In this case-control study, we…”
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S29 Dilated Main Pancreatic Duct Without a Visible Pancreatic Mass: Long-Term Follow-Up and Predictors of Future Pancreatic Ductal Adenocarcinoma by Chatterjee, Arjun, Lakhmani, Varun, Khasawneh, Hala A., Horibe, Masayasu, De la Fuente, Jaime, Bamlet, William R., Carlson, Erin E., Oberg, Ann L., Delgado, Adriana M., Doering, Karen A., Takahashi, Naoki, Goenka, Ajit H., Petersen, Gloria M., Majumder, Shounak

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Methylated DNA markers for plasma detection of ovarian cancer: Discovery, validation, and clinical feasibility by Marinelli, Lisa M., Kisiel, John B., Slettedahl, Seth W., Mahoney, Douglas W., Lemens, Maureen A., Shridhar, Vijayalakshmi, Taylor, William R., Staub, Julie K., Cao, Xiaoming, Foote, Patrick H., Burger, Kelli N., Berger, Calise K., O'Connell, Maria C., Doering, Karen A., Giakoumopoulos, Maria, Berg, Hannah, Volkmann, Carla, Solsrud, Adam, Allawi, Hatim T., Kaiser, Michael, Vaccaro, Abram M., Albright Crawford, Catherine, Moehlenkamp, Cynthia, Shea, Gracie, Deist, Melissa S., Schoolmeester, J. Kenneth, Kerr, Sarah E., Sherman, Mark E., Bakkum-Gamez, Jamie N.

“…Aberrant DNA methylation is an early event in carcinogenesis which could be leveraged to detect ovarian cancer (OC) in plasma. DNA from frozen OC tissues,…”
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Identification of pancreatic cancer risk factors from clinical notes using natural language processing by Sarwal, Dhruv, Wang, Liwei, Gandhi, Sonal, Sagheb Hossein Pour, Elham, Janssens, Laurens P., Delgado, Adriana M., Doering, Karen A., Mishra, Anup Kumar, Greenwood, Jason D., Liu, Hongfang, Majumder, Shounak

“…Screening for pancreatic ductal adenocarcinoma (PDAC) is considered in high-risk individuals (HRIs) with established PDAC risk factors, such as family history…”
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Multimodal Pancreatic Cancer Detection Using Methylated DNA Biomarkers in Pancreatic Juice and Plasma CA 19-9: A Prospective Multicenter Study by Engels, Megan M.L., Berger, Calise K., Mahoney, Douglas W., Hoogenboom, Sanne A., Sarwal, Dhruv, Klatte, Derk C.F., De La Fuente, Jaime, Gandhi, Sonal, Taylor, William R., Foote, Patrick H., Doering, Karen A., Delgado, Adriana M., Burger, Kelli N., Abu Dayyeh, Barham K., Bofill-Garcia, Aliana, Brahmbhatt, Bhaumik, Chandrasekhara, Vinay, Gleeson, Ferga C., Gomez, Victoria, Kumbhari, Vivek, Law, Ryan J., Lukens, Frank J., Raimondo, Massimo, Rajan, Elizabeth, Storm, Andrew C., Vargas Valls, Eric J., van Hooft, Jeanin E., Wallace, Michael B., Kisiel, John B., Majumder, Shounak

“…In previous studies, methylated DNA markers (MDMs) have been identified in pancreatic juice (PJ) for detecting pancreatic ductal adenocarcinoma (PDAC). In this…”
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Detection of endometrial cancer using tampon-based collection and methylated DNA markers by Bakkum-Gamez, Jamie N., Sherman, Mark E., Slettedahl, Seth W., Mahoney, Douglas W., Lemens, Maureen A., Laughlin-Tommaso, Shannon K., Hopkins, Matthew R., VanOosten, Ann, Shridhar, Viji, Staub, Julie K., Cao, Xiaoming, Foote, Patrick H., Clarke, Megan A., Burger, Kelli N., Berger, Calise K., O'Connell, Maria C., Doering, Karen A., Podratz, Karl C., DeStephano, Christopher C., Schoolmeester, J. Kenneth, Kerr, Sarah E., Wentzensen, Nicolas, Taylor, William R., Kisiel, John B.

“…Alterations in DNA methylation are early events in endometrial cancer (EC) development and may have utility in EC detection via tampon-collected vaginal fluid…”
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S410 Algorithm Training and Independent Test Set Performance for a Molecular Non-Endoscopic Test for Detection of Esophageal Adenocarcinoma and Barrett’s Esophagus in Multicenter Cohorts by Iyer, Prasad G., Slettedahl, Seth, Mahoney, Douglas, Krockenberger, Martin, Giakoumopoulos, Maria, Olson, Marilyn, Volkmann, Carla J., Otto, Jacob T., Solsrud, Adam M., Hanson, Hallie, Taylor, William, Lansing, Ramona, Gibbons, Erin, Passe, Melissa, Stewart, Molly, Valdez, Katelyn, Lozano, Kristen N., Doering, Karen A., Kelli, Burger N., Foote, Patrick H., Kim, Daniel S., Berger, Calise, Leggett, Cadman, Wang, Kenneth K., Falk, Gary, Wu, Tsung-Teh, Abrams, Julian, Ramirez, Francisco C., Kahn, Allon, Wolfsen, Herbert, Reddy, Chanakyaram A., Nguyen, Anh D., Konda, Vani, Trindade, Arvind, Kisiel, John

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Methylated DNA Markers for Sporadic Colorectal and Endometrial Cancer Are Strongly Associated with Lynch Syndrome Cancers by Bramblet, Rachel M, Bakkum-Gamez, Jamie N, Slettedahl, Seth W, Foote, Patrick H, Taylor, William R, Berger, Calise K, Gysbers, Brianna J, Arndt, Jacquelyn, Chen, Longwen, Doering, Karen A, Burger, Kelli N, Mahoney, Douglas W, Sherman, Mark E, Kisiel, John B, Samadder, N Jewel

“…Lynch syndrome (LS) markedly increases risks of colorectal and endometrial cancers. Early detection biomarkers for LS cancers could reduce the needs for…”
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Comparison of Tissue-Based Molecular Markers in Younger versus Older Patients with Colorectal Neoplasia by Limburg, Paul J, Mahoney, Douglas W, Ahlquist, David A, Allawi, Hatim T, Johnson, Scott C, Kaiser, Michael, Katerov, Viatcheslav E, Statz, Sandra, Graham, Rondell P, Foote, Patrick H, Doering, Karen A, Burger, Kelli N, Lidgard, Graham P, Kisiel, John B

“…Emerging colorectal cancer trends demonstrate increased incidence and mortality in younger populations, prompting consideration of average-risk colorectal…”
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Assessing the capacity of methylated DNA markers of cervical squamous cell carcinoma to discriminate oropharyngeal squamous cell carcinoma in human papillomavirus mediated disease by Bartemes, Kathleen R., Gochanour, Benjamin R., Routman, David M., Ma, Daniel J., Doering, Karen A., Burger, Kelli N., Foote, Patrick H., Taylor, William R., Mahoney, Douglas W., Berger, Calise K., Cao, Xiaoming, Then, Sara S., Haller, Travis J., Larish, Alyssa M., Moore, Eric J., Garcia, Joaquin J., Graham, Rondell P., Bakkum-Gamez, Jamie N., Kisiel, John B., Van Abel, Kathryn M.

“…•Methylated DNA markers distinguished cervical cancer from normal cervical tissue.•Cervical panel performed well but not optimally in HPV-associated oropharynx…”
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Tissue methylated DNA markers for sporadic pancreatic cancer are strongly associated with familial and genetically predisposed pancreatic cancer by Majumder, Shounak, Taylor, William R, Foote, Patrick H, Gysbers, Brianna J, Cao, Xiaoming, Mahoney, Douglas W, Burger, Kelli N, Doering, Karen A, Graham, Rondell P, Couch, Fergus J, Petersen, Gloria M, Kisiel, John B

“…High-risk individuals (HRIs) with familial and genetic predisposition to pancreatic ductal adenocarcinoma (PDAC) are eligible for screening. There is no…”
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Plasma Assay of Cell-Free Methylated DNA Markers of Colorectal Cancer: A Tumor-Agnostic Approach to Monitor Recurrence and Response to Anticancer Therapies by Zhu, Mojun, Taylor, William R, Mahoney, Douglas W, Then, Sara S, Berger, Calise K, Burger, Kelli N, Gonser, Anna M, Doering, Karen A, Xie, Hao, Foote, Patrick H, Kaiser, Michael W, Allawi, Hatim T, Hubbard, Joleen M, Kisiel, John B

“…Radiographic surveillance of colorectal cancer (CRC) after curative-intent therapy is costly and unreliable. Methylated DNA markers (MDMs) detected primary CRC…”
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Multi-Target Stool DNA Testing: High Positive Predictive Value Among Average Risk Patients New to Colorectal Cancer Screening: 289 by Eckmann, Jason D., Ebner, Derek, Bering, Jamie, Kahn, Allon, Rodriguez, Eduardo A., Devens, Mary, Lowrie, Kari, Doering, Karen A., Then, Sara, Burger, Kelli, Mahoney, Doug, Ahlquist, David A., Prichard, David, Wallace, Michael, Gurudu, Suryakanth R., Kisiel, John

“…Introduction: Multi-target stool DNA (MT-sDNA) testing was approved by the FDA for average-risk colorectal cancer (CRC) screening in 2014, and its use has…”
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Multi-Target Stool DNA Has a High Positive Predictive Value as an Interval Test After Colonoscopy: 291 by Eckmann, Jason D., Ebner, Derek, Bering, Jamie, Kahn, Allon, Rodriguez, Eduardo A., Devens, Mary, Lowrie, Kari, Doering, Karen A., Then, Sara, Burger, Kelli, Mahoney, Doug, Ahlquist, David A., Prichard, David, Wallace, Michael, Gurudu, Suryakanth R., Kisiel, John

“…Introduction: Colorectal cancer (CRC) has been reported in 6-9% of individuals within 3-5 years of reportedly negative screening colonoscopy. Approximately one…”
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Multi-Target Stool DNA Testing in Patients at Increased Risk for Colorectal Neoplasia Shows Similar Positive Predictive Value to Average Risk Patients: 290 by Eckmann, Jason D., Ebner, Derek, Bering, Jamie, Kahn, Allon, Rodriguez, Eduardo A., Devens, Mary, Lowrie, Kari, Doering, Karen A., Then, Sara, Burger, Kelli, Mahoney, Doug, Ahlquist, David A., Prichard, David, Wallace, Michael, Gurudu, Suryakanth R., Kisiel, John

“…Introduction: While colonoscopy is recommended for patients in whom symptoms or history suggest increased risk of colorectal neoplasia (CRN), an invasive…”
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Long-Term Outcomes and Risk of Pancreatic Cancer in Intraductal Papillary Mucinous Neoplasms by de la Fuente, Jaime, Chatterjee, Arjun, Lui, Jacob, Nehra, Avinash K, Bell, Matthew G, Lennon, Ryan J, Kassmeyer, Blake A, Graham, Rondell P, Nagayama, Hiroki, Schulte, Phillip J, Doering, Karen A, Delgado, Adriana M, Vege, Santhi Swaroop, Chari, Suresh T, Takahashi, Naoki, Majumder, Shounak

“…Intraductal papillary mucinous neoplasms (IPMNs) are pancreatic cysts that can give rise to pancreatic cancer (PC). Limited population data exist on their…”
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