Search Results - "Doerflinger, Marcel"

BH3‐only proteins: a 20‐year stock‐take by Doerflinger, Marcel, Glab, Jason A, Puthalakath, Hamsa

“…BH3‐only proteins are the sentinels of cellular stress, and their activation commits cells to apoptosis. Since the discovery of the first BH3‐only protein BAD…”
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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection by Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

“…Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during…”
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TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis by Nedeva, Christina, Menassa, Joseph, Duan, Mubing, Liu, Chuanxin, Doerflinger, Marcel, Kueh, Andrew J., Herold, Marco J., Fonseka, Pamali, Phan, Thanh Kha, Faou, Pierre, Rajapaksha, Harinda, Chen, Weisan, Hulett, Mark D., Puthalakath, Hamsa

“…Sepsis is a biphasic disease characterized by an acute inflammatory response, followed by a prolonged immunosuppressive phase. Therapies aimed at controlling…”
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Macrophage and neutrophil death programs differentially confer resistance to tuberculosis by Stutz, Michael Dominic, Allison, Cody Charles, Ojaimi, Samar, Preston, Simon Peter, Doerflinger, Marcel, Arandjelovic, Philip, Whitehead, Lachlan, Bader, Stefanie M., Batey, Daniel, Asselin-Labat, Marie-Liesse, Herold, Marco J., Strasser, Andreas, West, Nicholas P., Pellegrini, Marc

“…Apoptosis can potently defend against intracellular pathogens by directly killing microbes and eliminating their replicative niche. However, the reported…”
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Caspase-2 does not play a critical role in cell death induction and bacterial clearance during Salmonella infection by Engel, Sven, Doerflinger, Marcel, Lee, Ariane R., Strasser, Andreas, Herold, Marco J., Bedoui, Sammy, Bachem, Annabell

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DR5 and caspase-8 are dispensable in ER stress-induced apoptosis by Glab, Jason A, Doerflinger, Marcel, Nedeva, Christina, Jose, Irvin, Mbogo, George W, Paton, James C, Paton, Adrienne W, Kueh, Andrew J, Herold, Marco J, Huang, David CS, Segal, David, Brumatti, Gabriella, Puthalakath, Hamsa

“…The endoplasmic reticulum (ER) stress response constitutes cellular reactions triggered by a wide variety of stimuli that disturb folding of proteins, often…”
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Necroptosis does not drive disease pathogenesis in a mouse infective model of SARS-CoV-2 in vivo by M. Bader, Stefanie, Cooney, James P., Bhandari, Reet, Mackiewicz, Liana, Dayton, Merle, Sheerin, Dylan, Georgy, Smitha Rose, Murphy, James M., Davidson, Kathryn C., Allison, Cody C., Pellegrini, Marc, Doerflinger, Marcel

“…Necroptosis, a type of lytic cell death executed by the pseudokinase Mixed Lineage Kinase Domain-Like (MLKL) has been implicated in the detrimental…”
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Current State of Therapeutics for HTLV-1 by Wang, Tiana T, Hirons, Ashley, Doerflinger, Marcel, Morris, Kevin V, Ledger, Scott, Purcell, Damian F J, Kelleher, Anthony D, Ahlenstiel, Chantelle L

“…Human T cell leukaemia virus type-1 (HTLV-1) is an oncogenic retrovirus that causes lifelong infection in ~5-10 million individuals globally. It is endemic to…”
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Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria by Ly, Ann, Liao, Yang, Pietrzak, Halina, Ioannidis, Lisa J., Sidwell, Tom, Gloury, Renee, Doerflinger, Marcel, Triglia, Tony, Qin, Raymond Z., Groom, Joanna R., Belz, Gabrielle T., Good-Jacobson, Kim L., Shi, Wei, Kallies, Axel, Hansen, Diana S.

“…Despite the key role that antibodies play in protection, the cellular processes mediating the acquisition of humoral immunity against malaria are not fully…”
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A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain by Muhi, Stephen, Osowicki, Joshua, O'Brien, Daniel, Johnson, Paul D R, Pidot, Sacha, Doerflinger, Marcel, Marshall, Julia L, Pellegrini, Marc, McCarthy, James, Stinear, Timothy P

“…Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches…”
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Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection by Ebert, Gregor, Lopaticki, Sash, O’Neill, Matthew T., Steel, Ryan W.J., Doerflinger, Marcel, Rajasekaran, Pravin, Yang, Annie S.P., Erickson, Sara, Ioannidis, Lisa, Arandjelovic, Philip, Mackiewicz, Liana, Allison, Cody, Silke, John, Pellegrini, Marc, Boddey, Justin A.

“…Plasmodium sporozoites infect the liver and develop into exoerythrocytic merozoites that initiate blood-stage disease. The hepatocyte molecular pathways that…”
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A necroptosis-independent function of RIPK3 promotes immune dysfunction and prevents control of chronic LCMV infection by Preston, Simon P., Allison, Cody C., Schaefer, Jan, Clow, William, Bader, Stefanie M., Collard, Sophie, Forsyth, Wasan O., Clark, Michelle P., Garnham, Alexandra L., Li-Wai-Suen, Connie S. N., Peiris, Thanushi, Teale, Jack, Mackiewicz, Liana, Davidson, Sophia, Doerflinger, Marcel, Pellegrini, Marc

“…Necroptosis is a lytic and inflammatory form of cell death that is highly constrained to mitigate detrimental collateral tissue damage and impaired immunity…”
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Procalcitonin and Interleukin-10 May Assist in Early Prediction of Bacteraemia in Children With Cancer and Febrile Neutropenia by Doerflinger, Marcel, Haeusler, Gabrielle M, Li-Wai-Suen, Connie S N, Clark, Julia E, Slavin, Monica, Babl, Franz E, Allaway, Zoe, Mechinaud, Francoise, Smyth, Gordon K, De Abreu Lourenco, Richard, Phillips, Bob, Pellegrini, Marc, Thursky, Karin A

“…Febrile neutropenia (FN) causes treatment disruption and unplanned hospitalization in children with cancer. Serum biomarkers are infrequently used to stratify…”
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Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice by Doerflinger, Marcel, Glab, Jason, Nedeva, Christina, Jose, Irvin, Lin, Ann, O’Reilly, Lorraine, Allison, Cody, Pellegrini, Marc, Hotchkiss, Richard S., Puthalakath, Hamsa

“…Sepsis-induced lymphopenia is a major cause of morbidities in intensive care units and in populations with chronic conditions such as renal failure, diabetes,…”
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A human model of Buruli ulcer: Provisional protocol for a Mycobacterium ulcerans controlled human infection study by Muhi, Stephen, Marshall, Julia L, O'Brien, Daniel P, Johnson, Paul D R, Ross, Gayle, Ramakrishnan, Anand, Mackay, Laura K, Doerflinger, Marcel, McCarthy, James S, Jamrozik, Euzebiusz, Osowicki, Joshua, Stinear, Timothy P

“…Critical knowledge gaps have impeded progress towards reducing the global burden of disease due to , the cause of the neglected tropical disease Buruli ulcer…”
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A human model of Buruli ulcer: Provisional protocol for a Mycobacterium ulcerans controlled human infection study by Muhi, Stephen, Marshall, Julia L., O'Brien, Daniel P., Johnson, Paul D.R., Ross, Gayle, Ramakrishnan, Anand, Mackay, Laura K., Doerflinger, Marcel, McCarthy, James S., Jamrozik, Euzebiusz, Osowicki, Joshua, Stinear, Timothy P.

“…Critical knowledge gaps have impeded progress towards reducing the global burden of disease due to Mycobacterium ulcerans , the cause of the neglected tropical…”
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Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors by Calleja, Dale J, Kuchel, Nathan, Lu, Bernadine G C, Birkinshaw, Richard W, Klemm, Theresa, Doerflinger, Marcel, Cooney, James P, Mackiewicz, Liana, Au, Amanda E, Yap, Yu Q, Blackmore, Timothy R, Katneni, Kasiram, Crighton, Elly, Newman, Janet, Jarman, Kate E, Call, Melissa J, Lechtenberg, Bernhard C, Czabotar, Peter E, Pellegrini, Marc, Charman, Susan A, Lowes, Kym N, Mitchell, Jeffrey P, Nachbur, Ueli, Lessene, Guillaume, Komander, David

“…The COVID-19 pandemic continues unabated, emphasizing the need for additional antiviral treatment options to prevent hospitalization and death of patients…”
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Blood transcriptomics identifies immune signatures indicative of infectious complications in childhood cancer patients with febrile neutropenia by Haeusler, Gabrielle M, Garnham, Alexandra L, Li‐Wai‐Suen, Connie SN, Clark, Julia E, Babl, Franz E, Allaway, Zoe, Slavin, Monica A, Mechinaud, Francoise, Smyth, Gordon K, Phillips, Bob, Thursky, Karin A, Pellegrini, Marc, Doerflinger, Marcel

“…Objectives Febrile neutropenia (FN) is a major cause of treatment disruption and unplanned hospitalization in childhood cancer patients. This study…”
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Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death by Frank, Daniel, Garnish, Sarah E., Sandow, Jarrod J., Weir, Ashley, Liu, Lin, Clayer, Elise, Meza, Lizeth, Rashidi, Maryam, Cobbold, Simon A., Scutts, Simon R., Doerflinger, Marcel, Anderton, Holly, Lawlor, Kate E., Lalaoui, Najoua, Kueh, Andrew J., Eng, Vik Ven, Ambrose, Rebecca L., Herold, Marco J., Samson, Andre L., Feltham, Rebecca, Murphy, James M., Ebert, Gregor, Pearson, Jaclyn S., Vince, James E.

“…Pathogen recognition and TNF receptors signal via receptor interacting serine/threonine kinase-3 (RIPK3) to cause cell death, including MLKL-mediated…”
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Programmed cell death: the pathways to severe COVID-19? by Bader, Stefanie M, Cooney, James P, Pellegrini, Marc, Doerflinger, Marcel

“…Two years after the emergence of SARS-CoV-2, our understanding of COVID-19 disease pathogenesis is still incomplete. Despite unprecedented global collaborative…”
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