Search Results - "Doedens, Andrew L."

Constitutive Glycolytic Metabolism Supports CD8+ T Cell Effector Memory Differentiation during Viral Infection by Phan, Anthony T., Doedens, Andrew L., Palazon, Asis, Tyrakis, Petros A., Cheung, Kitty P., Johnson, Randall S., Goldrath, Ananda W.

“…Extensive metabolic changes accompany T cell activation, including a switch to glycolytic energy production and increased biosynthesis. Recent studies suggest…”
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FOXO1 opposition of CD8⁺ T cell effector programming confers early memory properties and phenotypic diversity by Delpoux, Arnaud, Lai, Chen-Yen, Hedrick, Stephen M., Doedens, Andrew L.

“…The factors and steps controlling postinfection CD8⁺ T cell terminal effector versus memory differentiation are incompletely understood. Whereas we found that…”
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Differentiation of CD8 memory T cells depends on Foxo1 by Hess Michelini, Rodrigo, Doedens, Andrew L, Goldrath, Ananda W, Hedrick, Stephen M

“…The forkhead O transcription factors (FOXO) integrate a range of extracellular signals, including growth factor signaling, inflammation, oxidative stress, and…”
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FOXO transcription factors throughout T cell biology by Hedrick, Stephen M., Michelini, Rodrigo Hess, Doedens, Andrew L., Goldrath, Ananda W., Stone, Erica L.

“…Key Points Forkhead box O (FOXO) transcription factors can affect many aspects of organismal physiology, including immunity, longevity, metabolism and…”
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Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen by Doedens, Andrew L, Phan, Anthony T, Stradner, Martin H, Fujimoto, Jessica K, Nguyen, Jessica V, Yang, Edward, Johnson, Randall S, Goldrath, Ananda W

“…The transcription factor HIF is induced in response to hypoxic stress, TCR activation and cytokines. Goldrath and colleagues show that HIF signaling enhances…”
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Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression by DOEDENS, Andrew L, STOCKMANN, Christian, RUBINSTEIN, Mark P, LIAO, Debbie, NA ZHANG, DENARDO, David G, COUSSENS, Lisa M, KARIN, Michael, GOLDRATH, Ananda W, JOHNSON, Randall S

“…T cells can inhibit tumor growth, but their function in the tumor microenvironment is often suppressed. Many solid tumors exhibit abundant macrophage…”
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FOXO1 constrains activation and regulates senescence in CD8 T cells by Delpoux, Arnaud, Marcel, Nimi, Hess Michelini, Rodrigo, Katayama, Carol D., Allison, Karmel A., Glass, Christopher K., Quiñones-Parra, Sergio M., Murre, Cornelis, Loh, Liyen, Kedzierska, Katherine, Lappas, Martha, Hedrick, Stephen M., Doedens, Andrew L.

“…Naive and memory T cells are maintained in a quiescent state, yet capable of rapid response and differentiation to antigen challenge via molecular mechanisms…”
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IL-2Rα mediates temporal regulation of IL-2 signaling and enhances immunotherapy by Su, Ee W, Moore, Caitlin J, Suriano, Samantha, Johnson, Christopher Bryce, Songalia, Neizel, Patterson, Alicia, Neitzke, Daniel J, Andrijauskaite, Kristina, Garrett-Mayer, Elizabeth, Mehrotra, Shikhar, Paulos, Chrystal M, Doedens, Andrew L, Goldrath, Ananda W, Li, Zihai, Cole, David J, Rubinstein, Mark P

“…Interleukin-2 (IL-2) is a lymphocyte growth factor that is an important component of many immune-based cancer therapies. The efficacy of IL-2 is thought to be…”
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Molecular Programming of Tumor-Infiltrating CD8+ T Cells and IL15 Resistance by Doedens, Andrew L, Rubinstein, Mark P, Gross, Emilie T, Best, J Adam, Craig, David H, Baker, Megan K, Cole, David J, Bui, Jack D, Goldrath, Ananda W

“…Despite clinical potential and recent advances, durable immunotherapeutic ablation of solid tumors is not routinely achieved. IL15 expands natural killer cell…”
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G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising CD8+ T cell immune responses by Rubinstein, Mark P, Salem, Mohamed L, Doedens, Andrew L, Moore, Caitlin J, Chiuzan, Cody, Rivell, Guillermo L, Cole, David J, Goldrath, Ananda W

“…Administration of recombinant G-CSF following cytoreductive therapy enhances the recovery of myeloid cells, minimizing the risk of opportunistic infection…”
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Zebrafish E‐cadherin: Expression during early embryogenesis and regulation during brain development by Babb, Sherry G., Barnett, Jessica, Doedens, Andrew L., Cobb, Nicole, Liu, Qin, Sorkin, Barbara C., Yelick, Pamela C., Raymond, Pamela A., Marrs, James A.

“…Zebrafish E‐cadherin (cdh1) cell adhesion molecule cDNAs were cloned. We investigated spatial and temporal expression of cdh1 during early embryogenesis…”
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FOXO1 opposition of CD8^sup +^ T cell effector programming confers early memory properties and phenotypic diversity by Delpoux, Arnaud, Lai, Chen-Yen, Hedrick, Stephen M, Doedens, Andrew L

“…The factors and steps controlling postinfection CD8+ T cell terminal effector versus memory differentiation are incompletely understood. Whereas we found that…”
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Hypoxia-inducible factors enhance the effector responses of [CD8.sup.+] T cells to persistent antigen by Doedens, Andrew L, Phan, Anthony T, Stradner, Martin H, Fujimoto, Jessica K, Nguyen, Jessica V, Yang, Edward, Johnson, Randall S, Goldrath, Ananda W

“…Cytolytic activity by [CD8.sup.+] cytotoxic T lymphocytes (CTLs) is a powerful strategy for the elimination of intracellular pathogens and tumor cells. The…”
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Hypoxia-inducible factors enhance the effector responses of CD8 super(+) T cells to persistent antigen by Doedens, Andrew L, Phan, Anthony T, Stradner, Martin H, Fujimoto, Jessica K, Nguyen, Jessica V, Yang, Edward, Johnson, Randall S, Goldrath, Ananda W

“…Cytolytic activity by CD8 super(+) cytotoxic T lymphocytes (CTLs) is a powerful strategy for the elimination of intracellular pathogens and tumor cells. The…”
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Macrophage Expression of Hypoxia-Inducible Factor-1a Suppresses T-Cell Function and Promotes Tumor Progression by Doedens, Andrew L, Stockmann, Christian, Rubinstein, Mark P, Liao, Debbie, Zhang, Na, DeNardo, David G, Coussens, Lisa M, Karin, Michael, Goldrath, Ananda W, Johnson, Randall S

“…T cells can inhibit tumor growth, but their function in the tumor microenvironment is often suppressed. Many solid tumors exhibit abundant macrophage…”
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Macrophage Expression of HIF-1α Suppresses T cell Function and Promotes Tumor Progression by Doedens, Andrew L., Stockmann, Christian, Rubinstein, Mark P., Liao, Debbie, Zhang, Na, DeNardo, David G., Coussens, Lisa M., Karin, Michael, Goldrath, Ananda W., Johnson, Randall S.

“…T cells can inhibit tumor growth, but their function in the tumor microenvironment is often suppressed. Many solid tumors exhibit abundant macrophage…”
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G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b super(+)Gr-1 super(+) myeloid cells without compromising CD8 super(+) T cell immune responses by Rubinstein, Mark P, Salem, Mohamed L, Doedens, Andrew L, Moore, Caitlin J, Chiuzan, Cody, Rivell, Guillermo L, Cole, David J, Goldrath, Ananda W

“…Background: Administration of recombinant G-CSF following cytoreductive therapy enhances the recovery of myeloid cells, minimizing the risk of opportunistic…”
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Role of myeloid Hypoxia-Inducible Factor-1alpha in the tumor microenvironment by Doedens, Andrew L

“…Solid tumors are frequently infiltrated by large numbers of non-cancerous hematopoietic cells, including macrophages. The pro-tumor or anti-tumor role of…”
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