Search Results - "Doe, Chris"

Temporal Patterning in the Drosophila CNS by Doe, Chris Q

“…A small pool of neural progenitors generates the vast diversity of cell types in the CNS. Spatial patterning specifies progenitor identity, followed by…”
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Temporal fate specification and neural progenitor competence during development by Kohwi, Minoree, Doe, Chris Q.

“…Key Points The vast neural diversity in the CNS is generated from a small pool of progenitors that produce distinct cell types in a specific order. The…”
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Neural stem cells: balancing self-renewal with differentiation by Doe, Chris Q

“…Stem cells are captivating because they have the potential to make multiple cell types yet maintain their undifferentiated state. Recent studies of Drosophila…”
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40 years of homeodomain transcription factors in the Drosophila nervous system by Doe, Chris Q, Thor, Stefan

“…Drosophila nervous system development progresses through a series of well-characterized steps in which homeodomain transcription factors (HDTFs) play key roles…”
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Developmentally Regulated Subnuclear Genome Reorganization Restricts Neural Progenitor Competence in Drosophila by Kohwi, Minoree, Lupton, Joshua R., Lai, Sen-Lin, Miller, Michael R., Doe, Chris Q.

“…Stem and/or progenitor cells often generate distinct cell types in a stereotyped birth order and over time lose competence to specify earlier-born fates by…”
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Combinatorial temporal patterning in progenitors expands neural diversity by Bayraktar, Omer Ali, Doe, Chris Q.

“…Human outer subventricular zone (OSVZ) neural progenitors and Drosophila type II neuroblasts both generate intermediate neural progenitors (INPs) that populate…”
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Drosophila embryonic type II neuroblasts: origin, temporal patterning, and contribution to the adult central complex by Walsh, Kathleen T, Doe, Chris Q

“…neuroblasts are an excellent model for investigating how neuronal diversity is generated. Most brain neuroblasts generate a series of ganglion mother cells…”
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Spindle orientation during asymmetric cell division by Doe, Chris Q, Siller, Karsten H

“…Development of a multicellular organism from a fertilized egg depends on a precise balance between symmetric cell divisions to expand the pool of similar…”
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A locomotor neural circuit persists and functions similarly in larvae and adult Drosophila by Lee, Kristen, Doe, Chris Q

“…Individual neurons can undergo drastic structural changes, known as neuronal remodeling or structural plasticity. One example of this is in response to…”
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Imp is required for timely exit from quiescence in Drosophila type II neuroblasts by Munroe, Jordan A, Syed, Mubarak H, Doe, Chris Q

“…Stem cells must balance proliferation and quiescence, with excess proliferation favoring tumor formation, and premature quiescence preventing proper…”
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Seven-up acts in neuroblasts to specify adult central complex neuron identity and initiate neuroblast decommissioning by Dillon, Noah R, Manning, Laurina, Hirono, Keiko, Doe, Chris Q

“…An open question in neurobiology is how diverse neuron cell types are generated from a small number of neural stem cells. In the Drosophila larval central…”
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Transcriptional profiling from whole embryos to single neuroblast lineages in Drosophila by Seroka, Austin, Lai, Sen-Lin, Doe, Chris Q.

“…Embryonic development results in the production of distinct tissue types, and different cell types within each tissue. A major goal of developmental biology is…”
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Steroid hormone induction of temporal gene expression in Drosophila brain neuroblasts generates neuronal and glial diversity by Syed, Mubarak Hussain, Mark, Brandon, Doe, Chris Q

“…An important question in neuroscience is how stem cells generate neuronal diversity. During Drosophila embryonic development, neural stem cells (neuroblasts)…”
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Astrocytes close a motor circuit critical period by Ackerman, Sarah D., Perez-Catalan, Nelson A., Freeman, Marc R., Doe, Chris Q.

“…Critical periods—brief intervals during which neural circuits can be modified by activity—are necessary for proper neural circuit assembly. Extended critical…”
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Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells by Boone, Jason Q., Doe, Chris Q.

“…Mammalian neural stem cells generate transit amplifying progenitors that expand the neuronal population, but these type of progenitors have not been studied in…”
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The role of astrocyte-mediated plasticity in neural circuit development and function by Perez-Catalan, Nelson A, Doe, Chris Q, Ackerman, Sarah D

“…Neuronal networks are capable of undergoing rapid structural and functional changes called plasticity, which are essential for shaping circuit function during…”
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Establishment and Maintenance of Neural Circuit Architecture by Heckman, Emily L, Doe, Chris Q

“…The ability to sense the world, process information, and navigate the environment depends on the assembly and continuous function of neural circuits in the…”
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Characterization of Drosophila larval crawling at the level of organism, segment, and somatic body wall musculature by Heckscher, Ellie S, Lockery, Shawn R, Doe, Chris Q

“…Understanding rhythmic behavior at the developmental and genetic levels has important implications for neurobiology, medicine, evolution, and robotics. We…”
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Notch signaling and Bsh homeodomain activity are integrated to diversify Drosophila lamina neuron types by Xu, Chundi, Ramos, Tyler B, Marshall, Owen J, Doe, Chris Q

“…Notch signaling is an evolutionarily conserved pathway for specifying binary neuronal fates, yet how it specifies different fates in different contexts remains…”
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The Hunchback temporal transcription factor determines motor neuron axon and dendrite targeting in Drosophila by Seroka, Austin Q, Doe, Chris Q

“…The generation of neuronal diversity is essential for circuit formation and behavior. Morphological differences in sequentially born neurons could be due to…”
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