Search Results - "Doe, C P"

Translation of flecainide- and mexiletine-induced cardiac sodium channel inhibition and ventricular conduction slowing from nonclinical models to clinical by Heath, B.M., Cui, Y., Worton, S., Lawton, B., Ward, G., Ballini, E., Doe, C.P.A., Ellis, C., Patel, B.A., McMahon, N.C.

“…Nonclinical in vivo models used for cardiovascular safety testing have not previously been studied for their sensitivity for detection of conduction slowing…”
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Reflex vascular responses in the anesthetized dog to large rapid changes in carotid sinus pressure by Doe, C P, Self, D A, Drinkhill, M J, McMahon, N, Myers, D S, Hainsworth, R

“…This study examined reflex vascular responses to large rapid increases and decreases in carotid sinus pressure to determine whether delayed or inappropriate…”
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Reflex vascular responses to abdominal venous distension in the anesthetized dog by Doe, C P, Drinkhill, M J, Myers, D S, Self, D A, Hainsworth, R

“…This was undertaken to determine whether distension of the subdiaphragmatic veins results in reflex vasoconstriction and interacts with the carotid baroreflex…”
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Reflex vascular responses to alterations in abdominal arterial pressure and flow in anaesthetized dogs by Drinkhill, M J, Doe, C P, Myers, D S, Self, D A, Hainsworth, R

“…The existence of abdominal arterial baroreceptors has long been controversial. Previously difficulties have been encountered in localizing a stimulus to…”
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Synthetic LXR agonists increase LDL in CETP species by Groot, Pieter H. E, Pearce, Nigel J, Yates, John W, Stocker, Claire, Sauermelch, Charles, Doe, Christopher P, Willette, Robert N, Olzinski, Alan, Peters, Tambra, d'Epagnier, Denise, Morasco, Kathleen O, Krawiec, John A, Webb, Christine L, Aravindhan, Karpagam, Jucker, Beat, Burgert, Mark, Ma, Chun, Marino, Joseph P, Collins, Jon L, Macphee, Colin H, Thompson, Scott K, Jaye, Michael

“…Liver X receptor (LXR) nuclear receptors regulate the expression of genes involved in whole body cholesterol trafficking, including absorption, excretion,…”
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An acute animal model that simulates the hemodynamic situations present during +Gz acceleration by Self, D A, Hainsworth, R, Krock, L P, Doe, C P, Latham, R D

“…Air combat maneuver acceleration (G) profiles with onset/offset patterns that occur faster than the response characteristics of the human cardiovascular system…”
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NO modulates myocardial O2 consumption in the nonhuman primate: an additional mechanism of action of amlodipine by Forfia, P R, Zhang, X, Knight, D R, Smith, A H, Doe, C P, Wolfgang, E A, Flynn, D M, Wolin, M S, Hintze, T H

“…Recent evidence from our laboratory and others suggests that nitric oxide (NO) is a modulator of in vivo and in vitro oxygen consumption in the murine and…”
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A method for QT correction based on beat-to-beat analysis of the QT/RR interval relationship in conscious telemetred beagle dogs by Batey, Andrew J., Doe, Christopher P.A.

“…Introduction: Drug-induced QT prolongation is a major clinical risk factor for arrhythmia induction, particularly torsades de pointes. QT interval is rate…”
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Tachycardia-induced primate model of heart failure in cardiovascular drug discovery by Smith, A.H, Wolfgang, E.A, Flynn, D.M, Doe, C.P.A, Knight, D.R

“…Congestive heart failure (CHF) is a complex, multifactoral disease involving genetic and environmental factors that represents a large unmet medical need…”
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