Search Results - "Dodson, Matthew"

Redox regulation by NRF2 in aging and disease by Schmidlin, Cody J., Dodson, Matthew B., Madhavan, Lalitha, Zhang, Donna D.

“…NRF2, a transcription factor that has been deemed the master regulator of cellular redox homeostasis, declines with age. NRF2 transcriptionally upregulates…”
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NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis by Dodson, Matthew, Castro-Portuguez, Raul, Zhang, Donna D

“…The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of the cellular antioxidant response, controlling the expression…”
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Cellular metabolic and autophagic pathways: Traffic control by redox signaling by Dodson, Matthew, Darley-Usmar, Victor, Zhang, Jianhua

“…It has been established that the key metabolic pathways of glycolysis and oxidative phosphorylation are intimately related to redox biology through control of…”
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Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis by Anandhan, Annadurai, Dodson, Matthew, Schmidlin, Cody J, Liu, Pengfei, Zhang, Donna D

“…Ferroptosis is a non-apoptotic mode of regulated cell death that is iron and lipid peroxidation dependent. As new mechanistic insight into ferroptotic…”
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Modulating NRF2 in Disease: Timing Is Everything by Dodson, Matthew, de la Vega, Montserrat Rojo, Cholanians, Aram B, Schmidlin, Cody J, Chapman, Eli, Zhang, Donna D

“…The transcription factor nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) is a central regulator of redox, metabolic, and protein homeostasis that…”
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Regulation of autophagy by protein post-translational modification by Wani, Willayat Yousuf, Boyer-Guittaut, Michaël, Dodson, Matthew, Chatham, John, Darley-Usmar, Victor, Zhang, Jianhua

“…Autophagy is a lysosome-mediated intracellular protein degradation process that involves about 38 autophagy-related genes as well as key signaling pathways…”
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Filtering through the role of NRF2 in kidney disease by Schmidlin, Cody J., Dodson, Matthew B., Zhang, Donna D.

“…Kidney disease affects ~ 10% of the population worldwide, resulting in millions of deaths each year. Mechanistically, oxidative stress is a major driver of…”
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NRF2 negatively regulates primary ciliogenesis and hedgehog signaling by Liu, Pengfei, Dodson, Matthew, Fang, Deyu, Chapman, Eli, Zhang, Donna D

“…Primary cilia are lost during cancer development, but the mechanism regulating cilia degeneration is not determined. While transcription factor nuclear…”
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ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells by Bao, Lingjie, Wu, Jianfa, Dodson, Matthew, Rojo de la Vega, Elisa Montserrat, Ning, Yan, Zhang, Zhenbo, Yao, Ming, Zhang, Donna D., Xu, Congjian, Yi, Xiaofang

“…Previously, we have demonstrated that NRF2 plays a key role in mediating cisplatin resistance in ovarian cancer. To further explore the mechanism underlying…”
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Multifunctional p62 Effects Underlie Diverse Metabolic Diseases by Long, Min, Li, Xing, Li, Li, Dodson, Matthew, Zhang, Donna D., Zheng, Hongting

“…p62, a protein capable of binding both ubiquitin and autophagy substrates, is well established as a key regulator in cancer and neurodegenerative diseases…”
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Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neurons by Dodson, Matthew, Wani, Willayat Y., Redmann, Matthew, Benavides, Gloria A., Johnson, Michelle S., Ouyang, Xiaosen, Cofield, Stacey S., Mitra, Kasturi, Darley-Usmar, Victor, Zhang, Jianhua

“…The production of reactive species contributes to the age-dependent accumulation of dysfunctional mitochondria and protein aggregates, all of which are…”
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RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE–dependent repression by Liu, Pengfei, de la Vega, Montserrat Rojo, Sammani, Saad, Mascarenhas, Joseph B., Kerins, Michael, Dodson, Matthew, Sun, Xiaoguang, Wang, Ting, Ooi, Aikseng, Garcia, Joe G. N., Zhang, Donna D.

“…NRF2 regulates cellular redox homeostasis, metabolic balance, and proteostasis by forming a dimer with small musculoaponeurotic fibrosarcoma proteins (sMAFs)…”
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The untapped potential of targeting NRF2 in neurodegenerative disease by Chen, Wei-Tai, Dodson, Matthew

“…Since its initial discovery almost three decades ago, the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) has been shown to regulate a…”
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Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease by Liu, Pengfei, Anandhan, Annadurai, Chen, Jinjing, Shakya, Aryatara, Dodson, Matthew, Ooi, Aikseng, Chapman, Eli, White, Eileen, Garcia, Joe GN, Zhang, Donna D.

“…Caloric excess and sedentary lifestyles have led to an epidemic of obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). The objective of…”
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Inhibition of autophagy and glycolysis by nitric oxide during hypoxia–reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons by Benavides, Gloria A, Liang, Qiuli, Dodson, Matthew, Darley-Usmar, Victor, Zhang, Jianhua

“…Excessive nitric oxide (NO) production is known to damage mitochondrial proteins and the autophagy repair pathway and so can potentially contribute to…”
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Use of item response theory to develop a return to work measure for acquired brain injury: The employment feasibility checklist by Dodson, Matthew B, Kyi, Min, Percy, Tania L M, Wadley, Megan, Deeker, Kelly, Matheson, Leonard N

“…The 2001 Feasibility Evaluation Checklist (FEC) is an assessment of work readiness for individuals with acquired brain injury (ABI). It establishes the…”
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The NRF2-LOC344887 signaling axis suppresses pulmonary fibrosis by Liu, Pengfei, Luo, Gang, Dodson, Matthew, Schmidlin, Cody J., Wei, Yongyi, Kerimoglu, Baris, Ooi, Aikseng, Chapman, Eli, Garcia, Joe GN, Zhang, Donna D.

“…Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible disease characterized by an increase in differentiation of fibroblasts to myofibroblasts…”
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The NRF2-p97-NRF2 negative feedback loop by Shakya, Aryatara, Liu, Pengfei, Godek, Jack, McKee, Nicholas W., Dodson, Matthew, Anandhan, Annadurai, Ooi, Aikseng, Garcia, Joe G.N., Costa, Max, Chapman, Eli, Zhang, Donna D.

“…p97 is a ubiquitin-targeted ATP-dependent segregase that regulates proteostasis, in addition to a variety of other cellular functions. Previously, we…”
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An NRF2 Perspective on Stem Cells and Ageing by Dodson, Matthew, Anandhan, Annadurai, Zhang, Donna D., Madhavan, Lalitha

“…Redox and metabolic mechanisms lie at the heart of stem cell survival and regenerative activity. NRF2 is a major transcriptional controller of cellular redox…”
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Bioenergetic adaptation in response to autophagy regulators during rotenone exposure by Giordano, Samantha, Dodson, Matthew, Ravi, Saranya, Redmann, Matthew, Ouyang, Xiaosen, Darley Usmar, Victor M., Zhang, Jianhua

“…Parkinson's disease is the second most common neurodegenerative disorder with both mitochondrial dysfunction and insufficient autophagy playing a key role in…”
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