Search Results - "Dodion, P."

Ridaforolimus as a single agent in advanced endometrial cancer: results of a single-arm, phase 2 trial by Colombo, N, McMeekin, D S, Schwartz, P E, Sessa, C, Gehrig, P A, Holloway, R, Braly, P, Matei, D, Morosky, A, Dodion, P F, Einstein, M H, Haluska, F

“…Background: This open-label, multicentre, phase 2 trial evaluated the efficacy and tolerability of the mammalian target of rapamycin inhibitor ridaforolimus in…”
Get full text

Phase I/IIa trial of the mammalian target of rapamycin inhibitor ridaforolimus (AP23573; MK-8669) administered orally in patients with refractory or advanced malignancies and sarcoma by Mita, M.M., Poplin, E., Britten, C.D., Tap, W.D., Rubin, E.H., Scott, B.B., Berk, L., Rivera, V.M., Loewy, J.W., Dodion, P., Haluska, F., Sarantopoulos, J., Mita, A., Tolcher, A.

“…Ridaforolimus is an inhibitor of mTOR with evidence of antitumor activity in an I.V. formulation. This multicenter, open-label, 3 + 3 design nonrandomized,…”
Get full text

A Phase I Trial of Oral Ridaforolimus (AP23573; MK-8669) in Combination with Bevacizumab for Patients with Advanced Cancers by Nemunaitis, J, Hochster, H.S, Lustgarten, S, Rhodes, R, Ebbinghaus, S, Turner, C.D, Dodion, P.F, Mita, M.M

“…Abstract Aims This phase I dose-escalation study was designed to evaluate the combination of the mammalian target of rapamycin inhibitor ridaforolimus with the…”
Get full text

Phase I and dose ranging, phase II studies with IPH2201, a humanized monoclonal antibody targeting HLA-E receptor CD94/NKG2A by Seymour, L., Tinker, A., Hirte, H., Wagtmann, N., Dodion, P.

Get full text

Dose-ranging, placebo-controlled study of cetirizine nasal spray in adults with perennial allergic rhinitis by Clement, P, Roovers, M H, Francillon, C, Dodion, P

“…A total of 360 patients with perennial allergic rhinitis were randomized in a placebo-controlled, dose-finding study comparing three concentrations (0.06%,…”
Get more information

Comparison of pharmacokinetics and bactericidal activity of teicoplanin and vancomycin by Lagast, H, Dodion, P, Klastersky, J

“…Teicoplanin (0.2 g) or vancomycin (1 g) were infused over 3 and 50 min respectively to six male volunteers in a cross-over study. Each drug was administered…”
Get more information

Intraperitoneal chemotherapy with cisplatin and melphalan by Piccart, M J, Abrams, J, Dodion, P F, Crespeigne, N, Sculier, J P, Pector, J C, Finet, C, Nouwijnck, C, Bondue, H, Atassi, G

“…Cisplatin and melphalan given ip exert a synergistic therapeutic effect against ascitic P388 leukemia in mice and have different dose-limiting toxic effects as…”
Get more information

Phase II trial with Brequinar (DUP-785, NSC 368390) in patients with metastatic colorectal cancer: a study of the Early Clinical Trials Group of the EORTC by Dodion, P F, Wagener, T, Stoter, G, Drozd, A, Lev, L M, Skovsgaard, T, Renard, J, Cavalli, F

Get more information

Chemotherapy in the elderly by Dodion, P

Get more information

Clinical pharmacology in oncology. Recent advances by Dodion, P

Get more information

Neoadjuvant chemotherapy with cisplatin, methotrexate, bleomycin and vincristine (CABO) in patients with stage III and IV squamous cell carcinoma of the head and neck by Recloux, P, Dodion, P F, Andry, G, Chantrain, G, Dor, P, Buyse, M, Van Houtte, P, Lemort, M, Haesendonck, P, Larsimont, D

“…Forty-six patients with Stage III-IV previously untreated squamous cell carcinoma of the head and neck were treated with neoadjuvant chemotherapy with…”
Get more information

Combination chemotherapy with methotrexate, bleomycin, and vincristine with or without cisplatin in advanced squamous cell carcinoma of the head and neck by Clavel, M, Cognetti, F, Dodion, P, Wildiers, J, Rosso, R, Rossi, A, Gignoux, B, Van Rymenant, M, Cortes-Funes, H, Dalesio, O

“…A total of 185 eligible patients with advanced inoperable squamous cell carcinoma of the head and neck were randomized into two groups; the cisplatin,…”
Get more information

Ridaforolimus (AP23573; MK-8669) in Combination with Trastuzumab for Patients with HER2-Positive Trastuzumab-Refractory Metastatic Breast Cancer: A Multicenter Phase 2 Clinical Trial by Yardley, D., Seiler, M., Ray-Coquard, I., Melichar, B., Hart, L., Dieras, V., Barve, M., Melnyk, A., Dorer, D., Turner, C., Dodion, P.

“…Abstract Background: Trastuzumab (T) resistance may be due to aberrant signaling through the PI3K/Akt pathway. Pre-clinical and retrospective clinical data…”
Get full text

Phase I study of intravenous menogaril administered intermittently by Dodion, P, Sessa, C, Joss, R, Crespeigne, N, Willems, Y, Kitt, M, Abrams, J, Finet, C, Brewer, J E, Adams, W J

“…Thirty-three adult patients with solid tumors were treated with menogaril, a new anthracycline antibiotic. The drug was given as a two-hour infusion every 4 to…”
Get more information

Immunoblastic lymphoma at the site of an infected vitallium bone plate by Dodion, P, Putz, P, Amiri-Lamraski, M H, Efira, A, de Martelaere, E, Heimann, R

Get more information

Results of the phase III, placebo-controlled trial (SUCCEED) evaluating the mTOR inhibitor ridaforolimus (R) as maintenance therapy in advanced sarcoma patients (pts) following clinical benefit from prior standard cytotoxic chemotherapy (CT) by Chawla, S. P., Blay, J., Ray-Coquard, I. L., Le Cesne, A., Staddon, A. P., Milhem, M. M., Penel, N., Riedel, R. F., Bui Nguyen, B., Cranmer, L. D., Reichardt, P., Bompas, E., Song, Y., Lee, R., Eid, J. E., Loewy, J., Haluska, F. G., Dodion, P. F., Demetri, G. D.

“…Abstract only…”
Get full text

Phase II trials with flavone acetic acid (NCS. 347512, LM975) in patients with advanced carcinoma of the breast, colon, head and neck and melanoma by KAYE, S. B, DODION, P, CAVALLI, F, CLAVEL, M, MONFARDINI, S, BOKKEL-HUININK, W, WAGENER, D. T, GUNDERSEN, S, STOTER, G, SMITH, J, RENARD, J, VAN GLABBEKE, M

“…Phase II trials of flavone acetic acid have been performed in a total of 87 patients including 17 with advanced breast cancer, 23 with advanced colorectal…”
Get full text

Interactions between cyclophosphamide and adriamycin metabolism in rats by Dodion, P, Riggs, Jr, C E, Akman, S R, Tamburini, J M, Colvin, O M, Bachur, N R

“…Rat liver microsomes under anaerobic conditions metabolize adriamycin (ADM) to 7-deoxyadriamycinol aglycone and 7-deoxyadriamycin aglycone. The metabolism of…”
Get more information

Interactions between cyclophosphamide and doxorubicin metabolism in rats. II. Effect of cyclophosphamide on the aldoketoreductase system by Dodion, P, Akman, S R, Tamburini, J M, Riggs, Jr, C E, Colvin, O M, Bachur, N R

“…Under anaerobic conditions, in comparison to liver microsomes obtained from normal controls, liver microsomes obtained from rats pretreated with…”
Get more information

Mucocutaneous side effects of Brequinar sodium. A new inhibitor of pyrimidine de novo biosynthesis by Schwartsmann, G, Bork, E, Vermorken, J B, Nieboer, C, Dodion, P, ten Bokkel Huinink, W W, Seldenrijk, C A, Armand, J P, Pinedo, H M

“…Brequinar sodium (NSC 368390; DUP 785) is a new inhibitor of pyrimidine de novo biosynthesis which has completed Phase I clinical trials within the framework…”
Get more information