Search Results - "Dodds, Sherry G."

Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice by Rodriguez, Karl A, Dodds, Sherry G, Strong, Randy, Galvan, Veronica, Sharp, Z D, Buffenstein, Rochelle

“…Rapamycin, an allosteric inhibitor of the mTOR kinase, increases longevity in mice in a sex-specific manner. In contrast to the widely accepted theory that a…”
Get full text

Degradation of Id proteins by the ubiquitin‐proteasome pathway by BOUNPHENG, MANGKEY A., DIMAS, JOSEPH J., DODDS, SHERRY G., CHRISTY, BARBARA A.

“…ABSTRACT Id proteins act as negative regulators of bHLH transcription factors by forming transcriptionally inactive protein complexes. The proposed function of…”
Get full text

Acarbose improved survival for Apc+/Min mice by Dodds, Sherry G., Parihar, Manish, Javors, Martin, Nie, Jia, Musi, Nicolas, Dave Sharp, Zelton, Hasty, Paul

“…Acarbose blocks the digestion of complex carbohydrates, and the NIA Intervention Testing Program (ITP) found that it improved survival when fed to mice. Yet,…”
Get full text

Rapamycin Extends Life Span in ApcMin/+ Colon Cancer FAP Model by Parihar, Manish, Dodds, Sherry G., Hubbard, Gene, Javors, Martin A., Strong, Randy, Hasty, Paul, Sharp, Zelton Dave

“…We previously showed that lifelong rapamycin treatment of short-lived ApcMin/+ mice, a model for familial adenomatous polyposis, resulted in a normal lifespan…”
Get full text

Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors by Livi, Carolina B, Hardman, Rulon L, Christy, Barbara A, Dodds, Sherry G, Jones, Diane, Williams, Charnae, Strong, Randy, Bokov, Alex, Javors, Martin A, Ikeno, Yuji, Hubbard, Gene, Hasty, Paul, Sharp, Zelton Dave

“…Chronic treatment of mice with an enterically released formulation of rapamycin (eRapa) extends median and maximum life span, partly by attenuating cancer. The…”
Get full text

eRapa Restores a Normal Life Span in a FAP Mouse Model by HASTY, Paul, LIVI, Carolina B, LISHI SUN, HUREZ, Vincent, CURIEL, Tyler J, ZELTON DAVE SHARP, DODDS, Sherry G, JONES, Diane, STRONG, Randy, JAVORS, Martin, FISCHER, Kathleen E, SLOANE, Lauren, MURTHY, Kruthi, HUBBARD, Gene

“…Mutation of a single copy of the adenomatous polyposis coli (APC) gene results in familial adenomatous polyposis (FAP), which confers an extremely high risk…”
Get full text

p53 and rapamycin are additive by Christy, Barbara, Demaria, Marco, Campisi, Judith, Huang, Jing, Jones, Diane, Dodds, Sherry G, Williams, Charnae, Hubbard, Gene, Livi, Carolina B, Gao, Xiaoli, Weintraub, Susan, Curiel, Tyler, Sharp, Z Dave, Hasty, Paul

“…Mechanistic target of rapamycin (mTOR) is a kinase found in a complex (mTORC1) that enables macromolecular synthesis and cell growth and is implicated in…”
Get full text

Adaptations to chronic rapamycin in mice by Dodds, Sherry G., Livi, Carolina B., Parihar, Manish, Hsu, Hang-Kai, Benavides, Adriana D., Morris, Jay, Javors, Martin, Strong, Randy, Christy, Barbara, Hasty, Paul, Sharp, Zelton Dave

“…Rapamycin inhibits mechanistic (or mammalian) target of rapamycin (mTOR) that promotes protein production in cells by facilitating ribosome biogenesis (RiBi)…”
Get full text

Abstract 671: mTORC1 suppression in Paneth cells prevents tumors in a mouse model of intestinal cancer by Parihar, Manish, Dodds, Sherry G., Hasty, Paul, Sharp, Zelton Dave

“…Abstract The mechanistic (or mammalian) target of rapamycin, mTOR, is a highly conserved PI3K-related kinase that regulates cell growth, proliferation,…”
Get full text

Rapamycin Extends Life Span in Apc Colon Cancer FAP Model by Parihar, Manish, Dodds, Sherry G., Hubbard, Gene, Javors, Martin A., Strong, Randy, Hasty, Paul, Sharp, Zelton Dave

Get full text

Rapamycin Extends Life Span in Apc Min/+ Colon Cancer FAP Model by Parihar, Manish, Dodds, Sherry G, Hubbard, Gene, Javors, Martin A, Strong, Randy, Hasty, Paul, Sharp, Zelton Dave

“…We previously showed that lifelong rapamycin treatment of short-lived Apc mice, a model for familial adenomatous polyposis, resulted in a normal lifespan. Apc…”
Get full text

Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice by Schatteman, G C, Hanlon, H D, Jiao, C, Dodds, S G, Christy, B A

“…Endothelial cell progenitors, angioblasts, have been detected in the peripheral blood of adult humans, mice, and rabbits. These cells have been shown to…”
Get full text

Negative Regulation of Selected bHLH Proteins by eHAND by Bounpheng, Mangkey A., Morrish, Tammy A., Dodds, Sherry G., Christy, Barbara A.

“…The bHLH protein eHAND plays an important role in the development of extraembryonic, mesodermal, and cardiac cell lineages, presumably through…”
Get full text

Characterization of the mouse JAB1 cDNA and protein by Bounpheng, Mangkey A., Melnikova, Irena N., Dodds, Sherry G., Chen, Heping, Copeland, Neal G., Gilbert, Debra J., Jenkins, Nancy A., Christy, Barbara A.

“…JAB1 was originally described as a transcriptional coactivator of c-Jun and Jun D. Recent data suggests that JAB1 is a component of a large protein complex,…”
Get full text