Search Results - "Dodds, Robert A"

Histological and Radiographic Evaluations of Demineralized Bone Matrix and Coralline Hydroxyapatite in the Rabbit Tibia by Zhukauskas, Rasa, Dodds, Robert A., Hartill, Caroline, Arola, Travis, Cobb, Ronald R., Fox, Casey

“…Complex fractures resulting in bone loss or impaired fracture healing remain problematic in trauma and orthopedic surgeries. Many bone graft substitutes have…”
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Human Osteoclast Cathepsin K Is Processed Intracellularly Prior to Attachment and Bone Resorption by Dodds, Robert A., James, Ian E., Rieman, David, Ahern, Reina, Hwang, Shing Mei, Connor, Janice R., Thompson, Scott D., Veber, Daniel F., Drake, Fred H., Holmes, Stephen, Lark, Michael W., Gowen, Maxine

“…Cathepsin K is a member of the papain superfamily of cysteine proteases and has been proposed to play a pivotal role in osteoclast‐mediated bone resorption. We…”
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Osteoprotegerin Is a Receptor for the Cytotoxic Ligand TRAIL by Emery, John G., McDonnell, Peter, Burke, Michael Brigham, Deen, Keith C., Lyn, Sally, Silverman, Carol, Dul, Edward, Appelbaum, Edward R., Eichman, Chris, DiPrinzio, Rocco, Dodds, Robert A., James, Ian E., Rosenberg, Martin, Lee, John C., Young, Peter R.

“…TRAIL is a tumor necrosis factor-related ligand that induces apoptosis upon binding to its death domain-containing receptors, DR4 and DR5. Two additional TRAIL…”
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Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats by Gowen, M, Stroup, G B, Dodds, R A, James, I E, Votta, B J, Smith, B R, Bhatnagar, P K, Lago, A M, Callahan, J F, DelMar, E G, Miller, M A, Nemeth, E F, Fox, J

“…Parathyroid hormone (PTH) is an effective bone anabolic agent, but it must be administered parenterally. An orally active anabolic agent would provide a…”
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Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts (∗) by Drake, Fred H., Dodds, Robert A., James, Ian E., Connor, Janice R., Debouck, Christine, Richardson, Susan, Lee-Rykaczewski, Elizabeth, Coleman, Lindsay, Rieman, David, Barthlow, Ray, Hastings, Gregg, Gowen, Maxine

“…Random high throughput sequencing of a human osteoclast cDNA library was employed to identify novel osteoclast-expressed genes. Of the 5475 ESTs obtained,…”
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A selective inhibitor of the osteoclastic V-H(+)-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats by Visentin, L, Dodds, R A, Valente, M, Misiano, P, Bradbeer, J N, Oneta, S, Liang, X, Gowen, M, Farina, C

“…A potent and selective inhibitor of the osteoclastic V-H(+)-ATPase, (2Z,4E)-5-(5,6-dichloro-2-indolyl)-2-methoxy-N-(1,2,2,6,…”
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Biomechanical and Radiographic Comparison of Demineralized Bone Matrix, and a Coralline Hydroxyapatite in a Rabbit Spinal Fusion Model by Dodds, Robert A., York-Ely, Amanda M., Zhukauskas, Rasa, Arola, Travis, Howell, John, Hartill, Caroline, Cobb, Ronald R., Fox, Casey

“…The use of bone grafts is an essential component in spinal fusion. Autologous bone has been shown to result in long-term stable arthrodesis between spinal…”
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Human osteoclasts, not osteoblasts, deposit osteopontin onto resorption surfaces: An in vitro and ex vivo study of remodeling bone by Dodds, Robert A., Connor, Janice R., James, Ian E., Lee Rykaczewski, Elizabeth, Appelbaum, Edward, Dul, Edward, Gowen, Maxine

“…Osteopontin is a phosphorylated glycoprotein believed to be secreted by osteoblasts and deposited into the bone matrix to facilitate osteoclast adhesion or to…”
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A cytochemical assay for osteoclast cathepsin K activity by Dodds, Robert A.

“…Cathepsin K is a member of the papain superfamily of cysteine proteases and plays a pivotal role in osteoclast‐mediated bone resorption. This enzyme is an…”
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Peptide Aldehyde Inhibitors of Cathepsin K Inhibit Bone Resorption Both In Vitro and In Vivo by Votta, Bartholomew J., Levy, Mark A., Badger, Alison, Bradbeer, Jeremy, Dodds, Robert A., James, Ian E., Thompson, Scott, Bossard, Mary J., Carr, Thomas, Connor, Janice R., Tomaszek, Thaddeus A., Szewczuk, Lawrence, Drake, Fred H., Veber, Daniel F., Gowen, Maxine

“…We have shown previously that cathepsin K, a recently identified member of the papain superfamily of cysteine proteases, is expressed selectively in…”
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Identification and Cloning of a Connective Tissue Growth Factor-like cDNA from Human Osteoblasts Encoding a Novel Regulator of Osteoblast Functions by Kumar, S, Hand, A T, Connor, J R, Dodds, R A, Ryan, P J, Trill, J J, Fisher, S M, Nuttall, M E, Lipshutz, D B, Zou, C, Hwang, S M, Votta, B J, James, I E, Rieman, D J, Gowen, M, Lee, J C

“…We have identified and cloned a novel connective tissue growth factor-like (CTGF-L) cDNA from primary human osteoblast cells encoding a 250-amino acid single…”
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Antagonism of the Osteoclast Vitronectin Receptor with an Orally Active Nonpeptide Inhibitor Prevents Cancellous Bone Loss in the Ovariectomized Rat by Lark, Michael W., Stroup, George B., Dodds, Robert A., Kapadia, Rasesh, Hoffman, Sandra J., Hwang, Shing Mei, James, Ian E., Lechowska, Beata, Liang, Xiaoguang, Rieman, David J., Salyers, Kevin L., Ward, Keith, Smith, Brian R., Miller, William H., Huffman, William F., Gowen, Maxine

“…An orally active, nonpeptide Arg‐Gly‐Asp (RGD) mimetic αvβ3 antagonist,…”
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Idoxifene, a novel selective estrogen receptor modulator, is effective in a rat model of adjuvant-induced arthritis by Badger, A M, Blake, S M, Dodds, R A, Griswold, D E, Swift, B A, Rieman, D J, Stroup, G B, Hoffman, S J, Gowen, M

“…Idoxifene, a selective estrogen receptor modulator, was evaluated in male and female rats with adjuvant-induced arthritis (AA). AA was induced in Lewis rats…”
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Applications of micro-CT and MR microscopy to study pre-clinical models of osteoporosis and osteoarthritis by Kapadia, R D, Stroup, G B, Badger, A M, Koller, B, Levin, J M, Coatney, R W, Dodds, R A, Liang, X, Lark, M W, Gowen, M

“…There is a tremendous unmet therapeutic need for the treatment of osteoporosis and osteoarthritis. The ovariectomized rat and the guinea pig are widely used…”
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Early loading‐related changes in the activity of glucose 6‐phosphate dehydrogenase and alkaline phosphatase in osteocytes and periosteal osteoblasts in rat fibulae in vivo by Dodds, Robert A., Ali, Nadire, Pead, Matthew J., Lanyon, Lance E.

“…The tibiae and fibulae of 14‐week‐old rats were subjected to a single 5 minutes period of cyclic longitudinal loading at 1 Hz. The activity of the enzymes…”
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Cathepsin K and the design of inhibitors of cathepsin K by Yamashita, D S, Dodds, R A

“…Cathepsin K, a cysteine protease of the papain family, was identified by sequencing complementary DNA libraries derived from osteoclasts. Cathepsin K can…”
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Azepanone-Based Inhibitors of Human and Rat Cathepsin K by Marquis, Robert W, Ru, Yu, LoCastro, Steven M, Zeng, Jin, Yamashita, Dennis S, Oh, Hye-Ja, Erhard, Karl F, Davis, Larry D, Tomaszek, Thaddeus A, Tew, David, Salyers, Kevin, Proksch, Joel, Ward, Keith, Smith, Brian, Levy, Mark, Cummings, Maxwell D, Haltiwanger, R. Curtis, Trescher, Gudrun, Wang, Bing, Hemling, Mark E, Quinn, Chad J, Cheng, H-Y, Lin, Fan, Smith, Ward W, Janson, Cheryl A, Zhao, Baoguang, McQueney, Michael S, D'Alessio, Karla, Lee, Chao-Pin, Marzulli, Antonia, Dodds, Robert A, Blake, Simon, James, Ian E, Gress, Catherine J, Bradley, Brian R, Lark, Michael W, Gowen, Maxine, Veber, Daniel F

“…The synthesis, in vitro activities, and pharmacokinetics of a series of azepanone-based inhibitors of the cysteine protease cathepsin K (EC 3.4.22.38) are…”
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CKβ-8 [CCL23], a novel CC chemokine, is chemotactic for human osteoclast precursors and is expressed in bone tissues by Votta, Bartholomew J., White, John R., Dodds, Robert A., James, Ian E., Connor, Janice R., Elizabeth, Lee-Rykaczewski, Eichman, Christopher F., Kumar, Sanjay, Lark, Michael W., Gowen, Maxine

“…We have previously demonstrated that a tartrate‐resistant acid phosphatase (TRAP)‐positive subpopulation of mononuclear cells isolated from collagenase digests…”
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Human osteoclastoma‐derived stromal cells: Correlation of the ability to form mineralized nodules in vitro with formation of bone in vivo by James, Ian E., Dodds, Robert A., Olivera, Diane L., Nuttall, Mark E., Gowen, Maxine

“…It has been suggested that the stromal element of human osteoclastomas contains osteoblastic cells. In this study, we demonstrate that osteoclast‐depleted,…”
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Purification and characterization of fully functional human osteoclast precursors by James, Ian E., Dodds, Robert A., Lee‐Rykaczewski, Elizabeth, Eichman, Christopher F., Connor, Janice R., Hart, Timothy K., Maleeff, Beverly E., Lackman, Richard D., Gowen, Maxine

“…The identification and purification of human osteoclast precursors is essential to further our understanding of the mechanisms that control human osteoclast…”
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