Search Results - "Doddapaneni, Harshavardhan"

Temporal development of the gut microbiome in early childhood from the TEDDY study by Stewart, Christopher J., Ajami, Nadim J., O’Brien, Jacqueline L., Hutchinson, Diane S., Smith, Daniel P., Wong, Matthew C., Ross, Matthew C., Lloyd, Richard E., Doddapaneni, HarshaVardhan, Metcalf, Ginger A., Muzny, Donna, Gibbs, Richard A., Vatanen, Tommi, Huttenhower, Curtis, Xavier, Ramnik J., Rewers, Marian, Hagopian, William, Toppari, Jorma, Ziegler, Anette-G., She, Jin-Xiong, Akolkar, Beena, Lernmark, Ake, Hyoty, Heikki, Vehik, Kendra, Krischer, Jeffrey P., Petrosino, Joseph F.

“…The development of the microbiome from infancy to childhood is dependent on a range of factors, with microbial–immune crosstalk during this time thought to be…”
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PRINCESS: comprehensive detection of haplotype resolved SNVs, SVs, and methylation by Mahmoud, Medhat, Doddapaneni, Harshavardhan, Timp, Winston, Sedlazeck, Fritz J

“…Long-read sequencing has been shown to have advantages in structural variation (SV) detection and methylation calling. Many studies focus either on SV,…”
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Molecular profiling predicts meningioma recurrence and reveals loss of DREAM complex repression in aggressive tumors by Patel, Akash J., Wan, Ying-Wooi, Al-Ouran, Rami, Revelli, Jean-Pierre, Cardenas, Maria F., Oneissi, Mazen, Xi, Liu, Jalali, Ali, Magnotti, John F., Muzny, Donna M., Doddapaneni, HarshaVardhan, Sebastian, Sherly, Heck, Kent A., Goodman, J. Clay, Gopinath, Shankar P., Liu, Zhandong, Rao, Ganesh, Plon, Sharon E., Yoshor, Daniel, Wheeler, David A., Zoghbi, Huda Y., Klisch, Tiemo J.

“…Meningiomas account for one-third of all primary brain tumors. Although typically benign, about 20% of meningiomas are aggressive, and despite the rigor of the…”
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Genetic architecture of laterality defects revealed by whole exome sequencing by Li, Alexander H, Hanchard, Neil A, Azamian, Mahshid, D'Alessandro, Lisa C A, Coban-Akdemir, Zeynep, Lopez, Keila N, Hall, Nancy J, Dickerson, Heather, Nicosia, Annarita, Fernbach, Susan, Boone, Philip M, Gambin, Tomaz, Karaca, Ender, Gu, Shen, Yuan, Bo, Jhangiani, Shalini N, Doddapaneni, HarshaVardhan, Hu, Jianhong, Dinh, Huyen, Jayaseelan, Joy, Muzny, Donna, Lalani, Seema, Towbin, Jeffrey, Penny, Daniel, Fraser, Charles, Martin, James, Lupski, James R, Gibbs, Richard A, Boerwinkle, Eric, Ware, Stephanie M, Belmont, John W

“…Aberrant left-right patterning in the developing human embryo can lead to a broad spectrum of congenital malformations. The causes of most laterality defects…”
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Mutational landscape of aggressive cutaneous squamous cell carcinoma by Pickering, Curtis R, Zhou, Jane H, Lee, J Jack, Drummond, Jennifer A, Peng, S Andrew, Saade, Rami E, Tsai, Kenneth Y, Curry, Jonathan L, Tetzlaff, Michael T, Lai, Stephen Y, Yu, Jun, Muzny, Donna M, Doddapaneni, Harshavardhan, Shinbrot, Eve, Covington, Kyle R, Zhang, Jianhua, Seth, Sahil, Caulin, Carlos, Clayman, Gary L, El-Naggar, Adel K, Gibbs, Richard A, Weber, Randal S, Myers, Jeffrey N, Wheeler, David A, Frederick, Mitchell J

“…Aggressive cutaneous squamous cell carcinoma (cSCC) is often a disfiguring and lethal disease. Very little is currently known about the mutations that drive…”
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The house spider genome reveals an ancient whole-genome duplication during arachnid evolution by Schwager, Evelyn E, Sharma, Prashant P, Clarke, Thomas, Leite, Daniel J, Wierschin, Torsten, Pechmann, Matthias, Akiyama-Oda, Yasuko, Esposito, Lauren, Bechsgaard, Jesper, Bilde, Trine, Buffry, Alexandra D, Chao, Hsu, Dinh, Huyen, Doddapaneni, HarshaVardhan, Dugan, Shannon, Eibner, Cornelius, Extavour, Cassandra G, Funch, Peter, Garb, Jessica, Gonzalez, Luis B, Gonzalez, Vanessa L, Griffiths-Jones, Sam, Han, Yi, Hayashi, Cheryl, Hilbrant, Maarten, Hughes, Daniel S T, Janssen, Ralf, Lee, Sandra L, Maeso, Ignacio, Murali, Shwetha C, Muzny, Donna M, Nunes da Fonseca, Rodrigo, Paese, Christian L B, Qu, Jiaxin, Ronshaugen, Matthew, Schomburg, Christoph, Schönauer, Anna, Stollewerk, Angelika, Torres-Oliva, Montserrat, Turetzek, Natascha, Vanthournout, Bram, Werren, John H, Wolff, Carsten, Worley, Kim C, Bucher, Gregor, Gibbs, Richard A, Coddington, Jonathan, Oda, Hiroki, Stanke, Mario, Ayoub, Nadia A, Prpic, Nikola-Michael, Flot, Jean-François, Posnien, Nico, Richards, Stephen, McGregor, Alistair P

“…The duplication of genes can occur through various mechanisms and is thought to make a major contribution to the evolutionary diversification of organisms…”
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Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication by Shinbrot, Eve, Henninger, Erin E, Weinhold, Nils, Covington, Kyle R, Göksenin, A Yasemin, Schultz, Nikolaus, Chao, Hsu, Doddapaneni, HarshaVardhan, Muzny, Donna M, Gibbs, Richard A, Sander, Chris, Pursell, Zachary F, Wheeler, David A

“…Tumors with somatic mutations in the proofreading exonuclease domain of DNA polymerase epsilon (POLE-exo*) exhibit a novel mutator phenotype, with markedly…”
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Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis by Chakraborty, Rikhia, Hampton, Oliver A., Shen, Xiaoyun, Simko, Stephen J., Shih, Albert, Abhyankar, Harshal, Lim, Karen Phaik Har, Covington, Kyle R., Trevino, Lisa, Dewal, Ninad, Muzny, Donna M., Doddapaneni, Harshavardhan, Hu, Jianhong, Wang, Linghua, Lupo, Philip J., Hicks, M. John, Bonilla, Diana L., Dwyer, Karen C., Berres, Marie-Luise, Poulikakos, Poulikos I., Merad, Miriam, McClain, Kenneth L., Wheeler, David A., Allen, Carl E., Parsons, D. Williams

“…Langerhans cell histiocytosis (LCH) is a myeloproliferative disorder characterized by lesions composed of pathological CD207+ dendritic cells with an…”
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Evolutionary History of Chemosensory-Related Gene Families across the Arthropoda by Eyun, Seong-Il, Soh, Ho Young, Posavi, Marijan, Munro, James B, Hughes, Daniel S T, Murali, Shwetha C, Qu, Jiaxin, Dugan, Shannon, Lee, Sandra L, Chao, Hsu, Dinh, Huyen, Han, Yi, Doddapaneni, HarshaVardhan, Worley, Kim C, Muzny, Donna M, Park, Eun-Ok, Silva, Joana C, Gibbs, Richard A, Richards, Stephen, Lee, Carol Eunmi

“…Chemosensory-related gene (CRG) families have been studied extensively in insects, but their evolutionary history across the Arthropoda had remained relatively…”
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Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design by Rokita, Jo Lynne, Rathi, Komal S., Cardenas, Maria F., Upton, Kristen A., Jayaseelan, Joy, Cross, Katherine L., Pfeil, Jacob, Egolf, Laura E., Way, Gregory P., Farrel, Alvin, Kendsersky, Nathan M., Patel, Khushbu, Gaonkar, Krutika S., Modi, Apexa, Berko, Esther R., Lopez, Gonzalo, Vaksman, Zalman, Mayoh, Chelsea, Nance, Jonas, McCoy, Kristyn, Haber, Michelle, Evans, Kathryn, McCalmont, Hannah, Bendak, Katerina, Böhm, Julia W., Marshall, Glenn M., Tyrrell, Vanessa, Kalletla, Karthik, Braun, Frank K., Qi, Lin, Du, Yunchen, Zhang, Huiyuan, Lindsay, Holly B., Zhao, Sibo, Shu, Jack, Baxter, Patricia, Morton, Christopher, Kurmashev, Dias, Zheng, Siyuan, Chen, Yidong, Bowen, Jay, Bryan, Anthony C., Leraas, Kristen M., Coppens, Sara E., Doddapaneni, HarshaVardhan, Momin, Zeineen, Zhang, Wendong, Sacks, Gregory I., Hart, Lori S., Krytska, Kateryna, Mosse, Yael P., Gatto, Gregory J., Sanchez, Yolanda, Greene, Casey S., Diskin, Sharon J., Vaske, Olena Morozova, Haussler, David, Gastier-Foster, Julie M., Kolb, E. Anders, Gorlick, Richard, Li, Xiao-Nan, Reynolds, C. Patrick, Kurmasheva, Raushan T., Houghton, Peter J., Smith, Malcolm A., Lock, Richard B., Raman, Pichai, Wheeler, David A., Maris, John M.

“…Accelerating cures for children with cancer remains an immediate challenge as a result of extensive oncogenic heterogeneity between and within histologies,…”
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Complete Genome Sequence of Citrus Huanglongbing Bacterium, 'Candidatus Liberibacter asiaticus' Obtained Through Metagenomics by Duan, Yongping, Zhou, Lijuan, Hall, David G, Li, Wenbin, Doddapaneni, Harshavardhan, Lin, Hong, Liu, Li, Vahling, Cheryl M, Gabriel, Dean W, Williams, Kelly P, Dickerman, Allan, Sun, Yijun, Gottwald,Tim

“…Citrus huanglongbing is the most destructive disease of citrus worldwide. It is spread by citrus psyllids and is associated with a low-titer, phloem-limited…”
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Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer by McMillan, Elizabeth A., Ryu, Myung-Jeom, Diep, Caroline H., Mendiratta, Saurabh, Clemenceau, Jean R., Vaden, Rachel M., Kim, Ju-Hwa, Motoyaji, Takashi, Covington, Kyle R., Peyton, Michael, Huffman, Kenneth, Wu, Xiaofeng, Girard, Luc, Sung, Yeojin, Chen, Pei-Hsaun, Mallipeddi, Prema L., Lee, Joo Young, Hanson, Jordan, Voruganti, Sukesh, Yu, Yunku, Park, Sunho, Sudderth, Jessica, DeSevo, Christopher, Muzny, Donna M., Doddapaneni, HarshaVardhan, Gazdar, Adi, Gibbs, Richard A., Hwang, Tae-Hyun, Heymach, John V., Wistuba, Ignacio, Coombes, Kevin R., Williams, Noelle S., Wheeler, David A., MacMillan, John B., Deberardinis, Ralph J., Roth, Michael G., Posner, Bruce A., Minna, John D., Kim, Hyun Seok, White, Michael A.

“…Diversity in the genetic lesions that cause cancer is extreme. In consequence, a pressing challenge is the development of drugs that target patient-specific…”
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Genome-to-function characterization of novel fungal P450 monooxygenases oxidizing polycyclic aromatic hydrocarbons (PAHs) by Syed, Khajamohiddin, Doddapaneni, Harshavardhan, Subramanian, Venkataramanan, Lam, Ying Wai, Yadav, Jagjit S.

“…► First report on identification of fungal P450 monooxygenases oxidizing HMW PAHs. ► A successful genome-to-function strategy to assign function to orphan P450…”
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Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney by Roy, Angshumoy, Kumar, Vijetha, Zorman, Barry, Fang, Erica, Haines, Katherine M., Doddapaneni, HarshaVardhan, Hampton, Oliver A., White, Simon, Bavle, Abhishek A., Patel, Nimesh R., Eldin, Karen W., John Hicks, M., Rakheja, Dinesh, Leavey, Patrick J., Skapek, Stephen X., Amatruda, James F., Nuchtern, Jed G., Chintagumpala, Murali M., Wheeler, David A., Plon, Sharon E., Sumazin, Pavel, Parsons, D. Williams

“…The X-linked BCL-6 co-repressor ( BCOR ) gene encodes a key constituent of a variant polycomb repressive complex (PRC) that is mutated or translocated in human…”
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Somatic mutations of esophageal adenocarcinoma: a comparison between Black and White patients by Lim, Hyeyeun, Gingras, Marie-Claude, Zhao, Jing, Byun, Jinyoung, Castro, Patricia D., Tsavachidis, Spiridon, Hu, Jianhong, Doddapaneni, Harshavardhan, Han, Yi, Muzny, Donna M., Gibbs, Richard A., Amos, Christopher I., Thrift, Aaron P.

“…Esophageal adenocarcinoma is the most common histological subtype of esophageal cancer in Western countries and shows poor prognosis with rapid growth. EAC is…”
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Complete Genome Sequence of ‘Candidatus Liberibacter solanacearum’, the Bacterium Associated with Potato Zebra Chip Disease by Lin, Hong, Lou, Binghai, Glynn, Jonathan M, Doddapaneni, Harshavardhan, Civerolo, Edwin L, Chen, Chuanwu, Duan, Yongping, Zhou, Lijuan, Vahling, Cheryl M, Yang, Ching-Hong

“…Zebra Chip (ZC) is an emerging plant disease that causes aboveground decline of potato shoots and generally results in unusable tubers. This disease has led to…”
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Cohort Profile: The Right Drug, Right Dose, Right Time: Using Genomic Data to Individualize Treatment Protocol (RIGHT Protocol) by Bielinski, Suzette J, St Sauver, Jennifer L, Olson, Janet E, Larson, Nicholas B, Black, John L, Scherer, Steven E, Bernard, Matthew E, Boerwinkle, Eric, Borah, Bijan J, Caraballo, Pedro J, Curry, Timothy B, Doddapaneni, HarshaVardhan, Formea, Christine M, Freimuth, Robert R, Gibbs, Richard A, Giri, Jyothsna, Hathcock, Matthew A, Hu, Jianhong, Jacobson, Debra J, Jones, Leila A, Kalla, Sara, Koep, Tyler H, Korchina, Viktoriya, Kovar, Christie L, Lee, Sandra, Liu, Hongfang, Matey, Eric T, McGree, Michaela E, McAllister, Tammy M, Moyer, Ann M, Muzny, Donna M, Nicholson, Wayne T, Oyen, Lance J, Qin, Xiang, Raj, Ritika, Roger, Véronique L, Rohrer Vitek, Carolyn R, Ross, Jason L, Sharp, Richard R, Takahashi, Paul Y, Venner, Eric, Walker, Kimberly, Wang, Liwei, Wang, Qiaoyan, Wright, Jessica A, Wu, Tsung-Jung, Wang, Liewei, Weinshilboum, Richard M

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A comparative genomic analysis of the oxidative enzymes potentially involved in lignin degradation by Agaricus bisporus by Doddapaneni, Harshavardhan, Subramanian, Venkataramanan, Fu, Bolei, Cullen, Dan

“…•We present a comparative genomic analysis of the oxidative enzymes in Agaricus bisporus.•Oxidative enzyme diversity is consistent with A. bisporus…”
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Genome-wide structural and evolutionary analysis of the P450 monooxygenase genes (P450ome) in the white rot fungus Phanerochaete chrysosporium: evidence for gene duplications and extensive gene clustering by Doddapaneni, Harshavardhan, Chakraborty, Ranajit, Yadav, Jagjit S

“…Phanerochaete chrysosporium, the model white rot basidiomycetous fungus, has the extraordinary ability to mineralize (to CO2) lignin and detoxify a variety of…”
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Primary Infection May Be an Underlying Factor Contributing to Lethal Hemorrhagic Disease Caused by Elephant Endotheliotropic Herpesvirus 3 in African Elephants ( Loxodonta africana ) by Pursell, Taylor, Spencer Clinton, Jennifer L, Tan, Jie, Peng, Rongsheng, Qin, Xiang, Doddapaneni, Harshavardhan, Menon, Vipin, Momin, Zeineen, Kottapalli, Kavya, Howard, Lauren, Latimer, Erin, Heaggans, Sarah, Hayward, Gary S, Ling, Paul D

“…Distinct but related species of elephant endotheliotropic herpesviruses (EEHVs) circulate within Asian and African elephant populations. Primary infection with…”
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