Search Results - "Dodd, Stephanie"

Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1 by Schoepfer, Joseph, Jahnke, Wolfgang, Berellini, Giuliano, Buonamici, Silvia, Cotesta, Simona, Cowan-Jacob, Sandra W, Dodd, Stephanie, Drueckes, Peter, Fabbro, Doriano, Gabriel, Tobias, Groell, Jean-Marc, Grotzfeld, Robert M, Hassan, A. Quamrul, Henry, Chrystèle, Iyer, Varsha, Jones, Darryl, Lombardo, Franco, Loo, Alice, Manley, Paul W, Pellé, Xavier, Rummel, Gabriele, Salem, Bahaa, Warmuth, Markus, Wylie, Andrew A, Zoller, Thomas, Marzinzik, Andreas L, Furet, Pascal

“…Chronic myelogenous leukemia (CML) arises from the constitutive activity of the BCR-ABL1 oncoprotein. Tyrosine kinase inhibitors (TKIs) that target the…”
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The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1 by Wylie, Andrew A., Schoepfer, Joseph, Jahnke, Wolfgang, Cowan-Jacob, Sandra W., Loo, Alice, Furet, Pascal, Marzinzik, Andreas L., Pelle, Xavier, Donovan, Jerry, Zhu, Wenjing, Buonamici, Silvia, Hassan, A. Quamrul, Lombardo, Franco, Iyer, Varsha, Palmer, Michael, Berellini, Giuliano, Dodd, Stephanie, Thohan, Sanjeev, Bitter, Hans, Branford, Susan, Ross, David M., Hughes, Timothy P., Petruzzelli, Lilli, Vanasse, K. Gary, Warmuth, Markus, Hofmann, Francesco, Keen, Nicholas J., Sellers, William R.

“…The selective allosteric ABL1 inhibitor ABL001 (asciminib) represents a new inhibitory mechanism for BCR–ABL1-driven malignancies, and its efficacy and…”
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Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective by Riedmaier, Arian Emami, DeMent, Kevin, Huckle, James, Bransford, Phil, Stillhart, Cordula, Lloyd, Richard, Alluri, Ravindra, Basu, Sumit, Chen, Yuan, Dhamankar, Varsha, Dodd, Stephanie, Kulkarni, Priyanka, Olivares-Morales, Andrés, Peng, Chi-Chi, Pepin, Xavier, Ren, Xiaojun, Tran, Thuy, Tistaert, Christophe, Heimbach, Tycho, Kesisoglou, Filippos, Wagner, Christian, Parrott, Neil

“…The effect of food on pharmacokinetic properties of drugs is a commonly observed occurrence affecting about 40% of orally administered drugs. Within the…”
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Understanding Mechanisms of Food Effect and Developing Reliable PBPK Models Using a Middle-out Approach by Pepin, Xavier J. H., Huckle, James E., Alluri, Ravindra V., Basu, Sumit, Dodd, Stephanie, Parrott, Neil, Emami Riedmaier, Arian

“…Over the last 10 years, 40% of approved oral drugs exhibited a significant effect of food on their pharmacokinetics (PK) and currently the only method to…”
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Co-crystal formation based on structural matching by Zhou, Liping, Dodd, Stephanie, Capacci-Daniel, Christina, Garad, Sudhakar, Panicucci, Riccardo, Sethuraman, Vijay

“…A co-crystal is defined as a single crystalline structure composed of two or more components with no proton transfer which are solid at room temperature. Our…”
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Pharmacokinetics of asciminib in the presence of CYP3A or P‐gp inhibitors, CYP3A inducers, and acid‐reducing agents by Hoch, Matthias, Huth, Felix, Sato, Masahiko, Sengupta, Tirtha, Quinlan, Michelle, Dodd, Stephanie, Kapoor, Shruti, Hourcade‐Potelleret, Florence

“…Asciminib is a first‐in‐class inhibitor of BCR::ABL1, specifically targeting the ABL myristoyl pocket. Asciminib is a substrate of CYP3A4 and P‐glycoprotein…”
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Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist by Pan, Shifeng, Wu, Xu, Jiang, Jiqing, Gao, Wenqi, Wan, Yongqin, Cheng, Dai, Han, Dong, Liu, Jun, Englund, Nathan P, Wang, Yan, Peukert, Stefan, Miller-Moslin, Karen, Yuan, Jing, Guo, Ribo, Matsumoto, Melissa, Vattay, Anthony, Jiang, Yun, Tsao, Jeffrey, Sun, Fangxian, Pferdekamper, AnneMarie C, Dodd, Stephanie, Tuntland, Tove, Maniara, Wieslawa, Kelleher, Joseph F, Yao, Yung-mae, Warmuth, Markus, Williams, Juliet, Dorsch, Marion

“…The blockade of aberrant hedgehog (Hh) signaling has shown promise for therapeutic intervention in cancer. A cell-based phenotypic high-throughput screen was…”
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Prediction of ARA/PPI Drug-Drug Interactions at the Drug Discovery and Development Interface by Dodd, Stephanie, Kollipara, Sivacharan, Sanchez-Felix, Manuel, Kim, Hyungchul, Meng, Qingshuo, Beato, Stefania, Heimbach, Tycho

“…Advances in understanding of human disease have prompted the U.S. Food and Drug Administration to classify certain molecules as "break-through therapies,"…”
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Automated Supersaturation Stability Assay to Differentiate Poorly Soluble Compounds in Drug Discovery by Skolnik, Suzanne M, Geraci, Gina M, Dodd, Stephanie

“…Increasingly, in vitro assays evaluate a compound's tendency to maintain supersaturation toward improving oral absorption. Throughput remains a challenge and…”
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Streamlining Food Effect Assessment — Are Repeated Food Effect Studies Needed? An IQ Analysis by Kesisoglou, Filippos, Basu, Sumit, Belubbi, Tejashree, Bransford, Philip, Chung, John, Dodd, Stephanie, Dolton, Michael, Heimbach, Tycho, Kulkarni, Priyanka, Lin, Wen, Moir, Andrea, Parrott, Neil, Pepin, Xavier, Ren, Xiaojun, Sharma, Pradeep, Stamatopoulos, Konstantinos, Tistaert, Christophe, Vaidhyanathan, Shruthi, Wagner, Christian, Riedmaier, Arian Emami

“…Current regulatory guidelines on drug-food interactions recommend an early assessment of food effect to inform clinical dosing instructions, as well as a…”
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Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor by Cho, Young Shin, Levell, Julian R, Liu, Gang, Caferro, Thomas, Sutton, James, Shafer, Cynthia M, Costales, Abran, Manning, James R, Zhao, Qian, Sendzik, Martin, Shultz, Michael, Chenail, Gregg, Dooley, Julia, Villalba, Brian, Farsidjani, Ali, Chen, Jinyun, Kulathila, Raviraj, Xie, Xiaoling, Dodd, Stephanie, Gould, Ty, Liang, Guiqing, Heimbach, Tycho, Slocum, Kelly, Firestone, Brant, Pu, Minying, Pagliarini, Raymond, Growney, Joseph D

“…Inhibition of mutant IDH1 is being evaluated clinically as a promising treatment option for various cancers with hotspot mutation at Arg132. Having identified…”
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Pharmacokinetics of Asciminib When Taken With Imatinib or With Food by Hoch, Matthias, Zack, Julia, Quinlan, Michelle, Huth, Felix, Forte, Sofia, Dodd, Stephanie, Aimone, Paola, Hourcade‐Potelleret, Florence

“…Asciminib, a first‐in‐class, Specifically Targeting the Abelson kinase Myristoyl Pocket (STAMP) inhibitor with the potential to overcome resistance to…”
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The development of self-emulsifying oil-in-water emulsion adjuvant and an evaluation of the impact of droplet size on performance by Shah, Ruchi R, Dodd, Stephanie, Schaefer, Mary, Ugozzoli, Mildred, Singh, Manmohan, Otten, Gillis R, Amiji, Mansoor M, O'Hagan, Derek T, Brito, Luis A

“…Microfluidization is an established technique for preparing emulsion adjuvant formulations for use in vaccines. Although this technique reproducibly yields…”
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Correction to: Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective by Riedmaier, Arian Emami, DeMent, Kevin, Huckle, James, Bransford, Phil, Stillhart, Cordula, Lloyd, Richard, Alluri, Ravindra, Basu, Sumit, Chen, Yuan, Dhamankar, Varsha, Dodd, Stephanie, Kulkarni, Priyanka, Olivares-Morales, Andrés, Peng, Chi-Chi, Pepin, Xavier, Ren, Xiaojun, Tran, Thuy, Tistaert, Christophe, Heimbach, Tycho, Kesisoglou, Filippos, Wagner, Christian, Parrott, Neil

“…An Erratum to this paper has been published: https://doi.org/10.1208/s12248-020-00535-z…”
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The allosteric inhibitor ABL001 enables dual targeting of BCRABL1 by Wylie, Andrew A, Schoepfer, Joseph, Jahnke, Wolfgang, Cowan-Jacob, Sandra W, Loo, Alice, Furet, Pascal, Marzinzik, Andreas L, Pelle, Xavier, Donovan, Jerry, Zhu, Wenjing, Buonamici, Silvia, Hassan, A. Quamrul, Lombardo, Franco, Iyer, Varsha, Palmer, Michael, Berellini, Giuliano, Dodd, Stephanie, Thohan, Sanjeev, Bitter, Hans, Branford, Susan, Ross, David M, Hughes, Timothy P, Petruzzelli, Lilli, Vanasse, K. Gary, Warmuth, Markus, Hofmann, Francesco, Keen, Nicholas J, Sellers, William R

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Optimization of 3‑Pyrimidin-4-yl-oxazolidin-2-ones as Orally Bioavailable and Brain Penetrant Mutant IDH1 Inhibitors by Zhao, Qian, Manning, James R., Sutton, James, Costales, Abran, Sendzik, Martin, Shafer, Cynthia M., Levell, Julian R., Liu, Gang, Caferro, Thomas, Cho, Young Shin, Palermo, Mark, Chenail, Gregg, Dooley, Julia, Villalba, Brian, Farsidjani, Ali, Chen, Jinyun, Dodd, Stephanie, Gould, Ty, Liang, Guiqing, Slocum, Kelly, Pu, Minying, Firestone, Brant, Growney, Joseph, Heimbach, Tycho, Pagliarini, Raymond

“…Mutant isocitrate dehydrogenase 1 (IDH1) is an attractive therapeutic target for the treatment of various cancers such as AML, glioma, and glioblastoma. We…”
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Abstract A144: Inhibition of 2-HG production in IDH mutant xenograft models by Slocum, Kelly L., Downall, Julia, Gould, Ty, Zafari, Mohammad, Dodd, Stephanie, Firestone, Brant, Pagliarini, Ray, Levell, Julian

“…Abstract Isocitrate dehydrogenase 1 and 2 (IDH1/2) oxidize isocitrateto α-ketoglutarate (α-KG), a cofactor needed for the function of over 100 enzymes1…”
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ABL001, a Potent Allosteric Inhibitor of BCR-ABL, Prevents Emergence of Resistant Disease When Administered in Combination with Nilotinib in an in Vivo Murine Model of Chronic Myeloid Leukemia by Wylie, Andrew, Schoepfer, Joseph, Berellini, Giuliano, Cai, Hongbo, Caravatti, Giorgio, Cotesta, Simona, Dodd, Stephanie, Donovan, Jerry, Erb, Bernhard, Furet, Pascal, Gangal, Geeti, Grotzfeld, Robert, Hassan, Quamrul, Hood, Tami, Iyer, Varsha, Jacob, Sandra, Jahnke, Wolfgang, Lombardo, Franco, Loo, Alice, Manley, Paul W., Marzinzik, Andreas, Palmer, Michael, Pelle, Xavier, Salem, Bahaa, Sharma, Sreenath, Thohan, Sanjeev, Zhu, Suzanne, Keen, Nicholas, Petruzzelli, Lilli, Vanasse, K. Gary, Sellers, William R

“…Background: Chronic myelogenous leukemia (CML) and a subset of acute lymphoblastic leukemia (ALL) are caused by the t(9;22)(q34;q11.2) chromosome…”
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COUNTERION QUANTIFICATION FOR DISCOVERY CHEMISTRY AND PRE-FORMULATION SALT SCREENING by Reilly, John, Wright, Penny, Larrow, Jay, Mann, Thierry, Twomey, Joseph, Grondine, Melissa, Dodd, Stephanie, Capacci-Daniel, Christina, Bilotta, Jennifer, Shah, Lipa, Towler, Christopher S.

“…A fast method was developed to determine the amount of anions and cations present in discovery samples using a reagent free ion chromatography system. The…”
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The influence of selected factors on the knowledge, perceptions, and academic practices of faculty of schools of public health in China about the increasing sex ratio as a priority social issue: Implications for professional education by Holaday, Stephanie Dodd

“…Faculty of schools of public health are in a position to teach students, conduct research on priority social issues, and collaborate with official and…”
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