Search Results - "Dodd, Darol"

Inhaled carbon nanotubes reach the subpleural tissue in mice by Bonner, James C, Ryman-Rasmussen, Jessica P, Cesta, Mark F, Brody, Arnold R, Shipley-Phillips, Jeanette K, Everitt, Jeffrey I, Tewksbury, Earl W, Moss, Owen R, Wong, Brian A, Dodd, Darol E, Andersen, Melvin E

“…Carbon nanotubes are shaped like fibres 1 and can stimulate inflammation at the surface of the peritoneum when injected into the abdominal cavity of mice 2 ,…”
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Incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene by Clewell, Harvey J., Campbell, Jerry L., Van Landingham, Cynthia, Franzen, Allison, Yoon, Miyoung, Dodd, Darol E., Andersen, Melvin E., Gentry, P. Robinan

“…Objective: To develop a physiologically based pharmacokinetic (PBPK) model for chloroprene in the mouse, rat and human, relying only on in vitro data to…”
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Formaldehyde: Integrating Dosimetry, Cytotoxicity, and Genomics to Understand Dose-Dependent Transitions for an Endogenous Compound by Andersen, Melvin E., Clewell, Harvey J., Bermudez, Edilberto, Dodd, Darol E., Willson, Gabrielle A., Campbell, Jerry L., Thomas, Russell S.

“…Formaldehyde (FA), an endogenous cellular aldehyde, is a rat nasal carcinogen. In this study, concentration and exposure duration transitions in FA mode of…”
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Editor's Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance by Cruzan, George, Bus, James S, Banton, Marcy I, Sarang, Satinder S, Waites, Robbie, Layko, Debra B, Raymond, James, Dodd, Darol, Andersen, Melvin E

“…Styrene is a mouse-specific lung carcinogen, and short-term mode of action studies have demonstrated that cytotoxicity and/or cell proliferation, and genomic…”
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Toxicity and occupational exposure assessment for hydroprocessed esters and fatty acids (HEFA) alternative jet fuels by Sterner, Teresa R., Wong, Brian A., Mumy, Karen L., James, R. Arden, Reboulet, James, Dodd, Darol E., Striebich, Richard C., Mattie, David R.

“…The U.S. Air Force (USAF) has pursued development of alternative fuels to augment or replace petroleum-based jet fuels. Hydroprocessed esters and fatty acids…”
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Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver by Andersen, Melvin E., Black, Michael B., Campbell, Jerry L., Pendse, Salil N., Clewell III, Harvey J., Pottenger, Lynn H., Bus, James S., Dodd, Darol E., Kemp, Daniel C., McMullen, Patrick D.

“…Dichloromethane (DCM) is a lung and liver carcinogen in mice at inhalation exposures≥2000ppm. The modes of action (MOA) of these responses have been attributed…”
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Strain-related differences in mouse lung gene expression over a two-year period of inhalation exposure to styrene: Relevance to human risk assessment by Andersen, Melvin E., Cruzan, George, Black, Michael B., Pendse, Salil N., Dodd, Darol E., Bus, James S., Sarang, Satinder S., Banton, Marcy I., Waites, Robbie, Layko, Debra B., McMullen, Patrick D.

“…Both CD-1 and C57BL/6 wildtype (C57BL/6-WT) mice show equivalent short-term lung toxicity from exposures to styrene, while long-term tumor responses are…”
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Toxicity and occupational exposure assessment for Fischer-Tropsch synthetic paraffinic kerosene by Mattie, David R., Sterner, Teresa R., Reddy, Gunda, Steup, David R., Zeiger, Errol, Wagner, Dean J., Kurtz, Katherine, Daughtrey, Wayne C., Wong, Brian A., Dodd, Darol E., Edwards, James T., Hinz, John P.

“…Fischer-Tropsch (FT) Synthetic Paraffinic Kerosene (SPK) jet fuel is a synthetic organic mixture intended to augment petroleum-derived JP-8 jet fuel use by the…”
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Persistent effects of Libby amphibole and amosite asbestos following subchronic inhalation in rats by Gavett, Stephen H, Parkinson, Carl U, Willson, Gabrielle A, Wood, Charles E, Jarabek, Annie M, Roberts, Kay C, Kodavanti, Urmila P, Dodd, Darol E

“…Human exposure to Libby amphibole (LA) asbestos increases risk of lung cancer, mesothelioma, and non-malignant respiratory disease. This study evaluated…”
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Early and Delayed Effects of Naturally Occurring Asbestos on Serum Biomarkers of Inflammation and Metabolism by Kodavanti, Urmila P., Andrews, Debora, Schladweiler, Mette C., Gavett, Stephen H., Dodd, Darol E., Cyphert, Jaime M.

“…Studies recently showed that intratracheal (IT) instillation of Libby amphibole (LA) increases circulating acute-phase proteins (APP; α-2 macroglobulin, A2M;…”
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Using gene expression profiling to evaluate cellular responses in mouse lungs exposed to V2O5 and a group of other mouse lung tumorigens and non-tumorigens by Black, Michael B., Dodd, Darol E., McMullen, Patrick D., Pendse, Salil, MacGregor, Judith A., Gollapudi, B. Bhaskar, Andersen, Melvin E.

“…Many compounds test positive for lung tumors in two-year NTP carcinogenicity bioassays in B6C3F1 mice. V2O5 was identified as a lung carcinogen in this assay,…”
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Subchronic toxicity evaluation of potassium bromate in Fischer 344 rats by Dodd, Darol E, Layko, Debra K, Cantwell, Katherine E, Willson, Gabrielle A, Thomas, Russell S

“…Highlights • Male F344 rats exposed to 400 mg/L potassium bromate in drinking water had increased kidney weights. • Hyaline droplets were observed in renal…”
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Subchronic hepatotoxicity evaluation of bromobenzene in Fischer 344 rats by Dodd, Darol E., Pluta, Linda J., Sochaski, Mark A., Banas, Deborah A., Thomas, Russell S.

“…ABSTRACT Male Fischer 344 (F344) rats were exposed to bromobenzene (BB) for 5 days and 2, 4 and 13 weeks. BB was administered by gavage (corn oil vehicle) at…”
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Nasal epithelial lesions in F344 rats following a 90-day inhalation exposure to naphthalene by Dodd, Darol E., Wong, Brian A., Gross, Elizabeth A., Miller, Rodney A.

“…Naphthalene (NA) was shown to be carcinogenic, causing respiratory epithelial adenoma in the nasal cavity of male F344 rats and olfactory epithelial…”
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Subchronic urinary bladder toxicity evaluation of N-Nitrosodiphenylamine in Fischer 344 rats by Dodd, Darol E., Pluta, Linda J., Sochaski, Mark A., Funk, Kathleen A., Thomas, Russell S.

“…ABSTRACT Female Fischer 344 (F344) rats were exposed to N‐nitrosodiphenylamine (NDPA) by dietary feed at concentrations of 0, 250, 1000, 2000, 3000 or 4000 ppm…”
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p53 codon 271 CGT to CAT mutant fraction does not increase in nasal respiratory and olfactory epithelia of rats exposed to inhaled naphthalene by Meng, Fanxue, Wang, Yiying, Myers, Meagan B., Wong, Brian A., Gross, Elizabeth A., Clewell, Harvey J., Dodd, Darol E., Parsons, Barbara L.

“…A 2-year rat tumor bioassay testing whole body exposure to naphthalene (NA) vapor found a significant increase in nasal respiratory epithelial adenomas in male…”
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Subchronic Thyroid Toxicity Evaluation of 4,4′-Methylenebis(N,N′-Dimethyl)Aniline in Fischer 344 Rats by Dodd, Darol E., Pluta, Linda J., Sochaski, Mark A., Funk, Kathleen A., Thomas, Russell S.

“…Female F344 rats were exposed to 4,4′-methylenebis(N,N′-dimethyl)aniline (MDA) by dietary feed at concentrations of 0, 50, 200, 375, 500, or 750 ppm for 5 d, 2…”
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Subchronic Hepatotoxicity Evaluation of Hydrazobenzene in Fischer 344 Rats by Dodd, Darol E., Pluta, Linda J., Sochaski, Mark A., Wall, Henry G., Thomas, Russell S.

“…Male F344 rats were exposed to hydrazobenzene (HZB) by dietary feed at concentrations of 0, 5, 20, 80, 200, or 300 ppm for 5 days, 2 weeks, 4 weeks, or 13…”
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Subchronic Toxicity Evaluation of Anthraquinone in Fischer 344 Rats by Dodd, Darol E., Layko, Debra K., Cantwell, Katherine E., Willson, Gabrielle A., Thomas, Russell S.

“…Female F344 rats were exposed to anthraquinone (AQ) by dietary feed at concentrations of 0, 50, 150, 469, 938, 1875, or 3750 ppm for 2 or 13 weeks. End points…”
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Nasal Olfactory Epithelial Lesions in F344 and SD Rats Following 1- and 5-Day Inhalation Exposure to Naphthalene Vapor by Dodd, Darol E., Gross, Elizabeth A., Miller, Rodney A., Wong, Brian A.

“…The exposure–response relationship and threshold for nasal epithelial effects of naphthalene (NP) vapor in F344 and SD rats were investigated in 1-day (6…”
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