Search Results - "Dodd, D. E."

Time- and concentration-dependent genomic responses of the rat airway to inhaled nickel subsulfide by Efremenko, A.Y., Campbell, J.L., Dodd, D.E., Oller, A.R., Clewell, H.J.

“…To provide insights into the mode of action for Ni3S2 lung carcinogenicity by examining gene expression changes in target cells after inhalation exposure. Gene…”
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Response to "letter concerning: Clewell (2019) incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene." (UIHT-2020-0053) by Clewell, H. J., Campbell, J. L., Van Landingham, C., Franzen, A., Yoon, M., Dodd, D. E., Andersen, M. E., Gentry, P. R.

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Time‐ and concentration‐dependent genomic responses of the rat airway to inhaled nickel sulfate by Efremenko, A. Y., Campbell, J. L., Dodd, D. E., Oller, A. R., Clewell, H. J.

“…While insoluble nickel subsulfide (Ni3S2) was carcinogenic in the lung in a 2‐year rat bioassay, soluble nickel sulfate hexahydrate (NiSO4*6H2O) was not. To…”
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Transcriptional responses in the rat nasal epithelium following subchronic inhalation of naphthalene vapor by Clewell, H.J., Efremenko, A., Campbell, J.L., Dodd, D.E., Thomas, R.S.

“…Male and female Fischer 344 rats were exposed to naphthalene vapors at 0 (controls), 0.1, 1, 10, and 30ppm for 6h/d, 5 d/wk, over a 90-day period. Following…”
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Hepatotoxicity in guinea pigs following acute inhalation exposure to 1,1-dichloro-2,2,2-trifluoroethane by Marit, G B, Dodd, D E, George, M E, Vinegar, A

“…Groups of 10 male Hartley guinea pigs were exposed to 3.0, 2.0, 1.0, or 0.1% (v/v) 1,1-Dichloro-2,2,2-trifluoroethane (HCFC-123) or 1.0% (v/v) halothane by…”
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Central neurotoxicity induced by subchronic exposure to 2,4-pentanedione vapour by Garman, R H, Dodd, D E, Ballantyne, B

“…1. Male and female Fischer 344 rats were exposed to 2,4-pentanedione (2,4-PD) vapour acutely (4 h) at 1265 or 1811 ppm, or for 6 h day-1, 5 days a week for 14…”
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Cardiac sensitization testing of the halon replacement candidates trifluoroiodomethane (CF3I) and 1,1,2,2,3,3,3-heptafluoro-1-iodopropane (C3F7I) by DODD, D. E, VINEGAR, A

“…Trifluoroiodomethane (CF3I) and 1,1,2,2,3,3,3-heptafluoro-1-iodopropane (C3F7I) have been considered as replacement candidates for halon fire suppressants due…”
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Two-generation reproductive toxicity study of inhaled toluene diisocyanate vapor in CD rats by TYL, R. W, NEEPER-BRADLEY, T. L, FISHER, L. C, DODD, D. E, PRITTS, I. M, LOSCO, P. E, LYON, J. P, LANDRY, T. D

“…Twenty-eight 42-day-old pups/sex/group (F0) were exposed to toluene diisocyanate vapor (TDI; 80% 2,4-TDI, 20% 2,6-TDI) by inhalation at 0.0, 0.02, 0.08, or 0.3…”
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Developmental toxicity evaluation of inhaled toluene diisocyanate vapor in CD rats by TYL, R. W, FISHER, L. C, DODD, D. E, PRITTS, I. M, KUBENA, M. F, LOSCO, P. E, TROUP, C. M, LYON, J. P, LANDRY, T. D

“…Mated female CD (Sprague-Dawley) rats, 25/group, were exposed to toluene diisocyanate (TDI) vapor, for six h/day on gestational days (gd) 6 through 15, at…”
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REPRODUCTIVE TOXICITY SCREEN OF TRIFLUOROIODOMETHANE (CF3I) IN SPRAGUE-DAWLEY RATS by Dodd, D.E., Leahy, H.F., Feldmann, M.L., English, J.H., Vinegar, A.

“…CF3I is being considered by the U.S. Air Force as a replacement for Halon 1301 for fireextinguishing requirements in unoccupied spaces. The purpose of this…”
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Evaluation of 13-week inhalation toxicity study on methyl t-butyl ether (MTBE) in Fischer 344 rats by Lington, A W, Dodd, D E, Ridlon, S A, Douglas, J F, Kneiss, J J, Andrews, L S

“…Methyl-t-butyl ether (MTBE) is widely used as an octane enhancing agent in gasoline. A 13-week inhalation study was conducted in Fischer 344 rats to provide…”
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A 90-day drinking water toxicity study in rats of the environmental contaminant ammonium perchlorate by SIGLIN, Joseph C, MATTIE, David R, DODD, Darol E, HILDEBRANDT, Paul K, BAKER, William H

“…Perchlorate (ClO(4)(-)), the dissociated anion of perchlorate salts such as ammonium, potassium, and sodium perchlorate, has been recently recognized as a…”
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Metabolism and pharmacokinetics of selected halon replacement candidates by Dodd, D E, Brashear, W T, Vinegar, A

“…Metabolism studies were conducted using Fischer 344 and Sprague-Dawley rats following inhalation exposure to 1.0% (v/v) air atmospheres of…”
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Air Force approach to risk assessment for halon replacements by McDougal, J N, Dodd, D E

“…Finding safe, environmentally acceptable, and effective replacements for Halon fire-extinguishing agents and other chemicals banned by the Montreal Protocol is…”
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Toxicology of methyl isocyanate by Dodd, D E

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Acute, 2-week, and 13-week inhalation toxicity studies on dimethylethoxysilane vapor in Fischer 344 rats by Dodd, D E, Stuart, B O, Rothenberg, S J, Kershaw, M, Mann, P C, James, J T, Lam, C W

“…Dimethylethoxysilane (DMES), a volatile liquid, is used by NASA to waterproof the heat-protective silica tiles and blankets on the Space Shuttle. Acute, 2-wk,…”
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Short-term and Subchronic Repeated Exposure Studies with 5-Ethylidene-2-norbornene Vapor in the Rat by Ballantyne, Bryan, Norris, James C., Dodd, Darol E., Klonne, Dennis R., Losco, Patricia E., Neptun, Douglas A., Price, Shirley C., Grasso, Paul

“…5‐Ethylidene‐2‐norbornene (ENB) is an industrial chemical whose physical properties indicate a likelihood for vapor exposure to humans. The potential for…”
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Acute vapour inhalation toxicity of acrolein and its influence as a trace contaminant in 2-methoxy-3,4-dihydro-2H-pyran by Ballantyne, B, Dodd, D E, Pritts, I M, Nachreiner, D J, Fowler, E H

“…1. The LC50 values for acrolein (AC) vapour to Sprague-Dawley rats (combined sexes) were determined to be 26 ppm (1 h) and 8.3 ppm (4 h). Signs of severe…”
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Subchronic toxicity study of dicyclopentadiene vapor in rats by Bevan, C, Snellings, W M, Dodd, D E, Egan, G F

“…Fischer 344 rats were exposed by inhalation to 0, 1, 5 or 50 ppm dicyclopentadiene (DCPD) vapor 6 hr/day, 5 days/week for 13 weeks, followed by a 13-week…”
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Respiratory Tract Changes in Guinea Pigs, Rats, and Mice Following a Single Six-Hour Exposure to Methyl Isocyanate Vapor by Fowler, Edward H., Dodd, Darol E.

“…Groups of male and female Fischer 344 rats, B6C3F1 mice, and Hartley guinea pigs were exposed once for 6 hr to mean concentrations of 10.5, 5.4, 2.4, 1.0, or 0…”
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