A Randomized, Double-Blind Trial of Nystatin Therapy for the Candidiasis Hypersensitivity Syndrome

IN recent years Candida albicans, a yeast that is part of the normal human intestinal flora, has been thought by some to cause a disorder variously known as the candidiasis hypersensitivity syndrome, chronic candidiasis, candida-related complex, and the "yeast connection." 1 2 3 According...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 323; no. 25; pp. 1717 - 1723
Main Authors:	Dismukes, William E, Wade, J. Scott, Lee, Jeannette Y, Dockery, Bonita K, Hain, Jack D
Format:	Journal Article
Language:	English
Published:	Boston, MA Massachusetts Medical Society 20-12-1990
Subjects:	Administration, Oral Adult Allergies Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Asthma Biological and medical sciences Birth control Candida albicans Candidiasis Candidiasis, Vulvovaginal - drug therapy Capsules Chronic fatigue syndrome Chronic infection Double-Blind Method Double-blind studies Drug Administration Schedule Drugs Evidence-based medicine Fatigue Female Health care Humans Hypersensitivity Hypersensitivity - drug therapy Infections Infectious diseases Medical research Medical sciences Mental depression Nystatin Nystatin - administration & dosage Nystatin - therapeutic use Patients Pharmacology. Drug treatments Psychological assessment Syndrome Vagina Vaginitis Women Womens health Human Infection Antifungal agent Candidiasis Chemotherapy Treatment Mycosis Female
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Summary:	IN recent years Candida albicans, a yeast that is part of the normal human intestinal flora, has been thought by some to cause a disorder variously known as the candidiasis hypersensitivity syndrome, chronic candidiasis, candida-related complex, and the "yeast connection." 1 2 3 According to Truss and Crook, 1 , 2 the primary proponents of this hypothesis, the syndrome is caused by an overgrowth of C. albicans on mucous membranes and in the gastrointestinal tract in response to several factors, including the use of broad-spectrum antibiotics or oral contraceptives and pregnancy. This overgrowth of C. albicans results in inflammation and invasion of mucous membranes, with attendant . . .
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-News-3
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM199012203232501