Search Results - "Dobson, Philip F."

Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss by Dobson, Philip F., Dennis, Ella P., Hipps, Daniel, Reeve, Amy, Laude, Alex, Bradshaw, Carla, Stamp, Craig, Smith, Anna, Deehan, David J., Turnbull, Doug M., Greaves, Laura C.

“…The pathogenesis of declining bone mineral density, a universal feature of ageing, is not fully understood. Somatic mitochondrial DNA (mtDNA) mutations…”
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A novel immunofluorescent assay to investigate oxidative phosphorylation deficiency in mitochondrial myopathy: understanding mechanisms and improving diagnosis by Rocha, Mariana C., Grady, John P., Grünewald, Anne, Vincent, Amy, Dobson, Philip F., Taylor, Robert W., Turnbull, Doug M., Rygiel, Karolina A.

“…Oxidative phosphorylation defects in human tissues are often challenging to quantify due to a mosaic pattern of deficiency. Biochemical assays are difficult to…”
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Variant load of mitochondrial DNA in single human mesenchymal stem cells by Hipps, Daniel, Pyle, Angela, Porter, Anna L. R., Dobson, Philip F., Tuppen, Helen, Lawless, Conor, Russell, Oliver M., Turnbull, Doug M., Deehan, David J., Hudson, Gavin

“…Heteroplasmic mitochondrial DNA (mtDNA) variants accumulate as humans age, particularly in the stem-cell compartments, and are an important contributor to…”
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Prevention of infection in primary THA and TKA by Dobson, Philip F., Reed, Michael R.

“…Rates of peri-prosthetic joint infection (PJI) in primary total hip and total knee arthroplasty range between 0.3% and 1.9%, and up to 10% in revision cases…”
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Detecting respiratory chain defects in osteoblasts from osteoarthritic patients using imaging mass cytometry by Hipps, Daniel, Dobson, Philip F., Warren, Charlotte, McDonald, David, Fuller, Andrew, Filby, Andrew, Bulmer, David, Laude, Alex, Russell, Oliver, Deehan, David J., Turnbull, Doug M., Lawless, Conor

“…Osteoporosis is a skeletal disease which is characterised by reduced bone mass and microarchitecture, with a subsequent loss of strength that predisposes to…”
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Unique quadruple immunofluorescence assay demonstrates mitochondrial respiratory chain dysfunction in osteoblasts of aged and PolgA−/− mice by Dobson, Philip F., Rocha, Mariana C., Grady, John P., Chrysostomou, Alexia, Hipps, Daniel, Watson, Sharon, Greaves, Laura C., Deehan, David J., Turnbull, Doug M.

“…Fragility fractures caused by osteoporosis affect millions of people worldwide every year with significant levels of associated morbidity, mortality and costs…”
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Paediatric diaphyseal forearm fractures – Treatment modalities and outcome by Shields, David W, Dobson, Philip F, Webb, Mark, DeGheldere, Antoine

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Delayed ulnar nerve palsy secondary to ulnar artery pseudoaneurysm distal to Guyon's canal following penetrating trauma to the hand by Dobson, P F, Purushothaman, B, Michla, Y, England, S, Krishnan, M K, Tourret, L

“…Compression of the ulnar nerve in Guyon's canal is an uncommon phenomenon. Reports of ulnar nerve palsy secondary to ulnar artery pseudoaneurysm at this…”
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