Development of the thymus and Peyer's patches in the first year of life in red deer ( Cervus elaphus)

Development of the thymus and Peyer's patches in the first year of life in red deer ( Cervus elaphus)

In young ruminants, as in most animals, the thymus and Peyer's patches (PP) play a key role in immune function. In sheep and cattle it has been shown that they follow a recognisable pattern of development throughout early life but a study of these tissues in red deer ( Cervus elaphus) had not b...

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Bibliographic Details
Published in:Veterinary immunology and immunopathology Vol. 137; no. 1; pp. 93 - 98
Main Authors: Dobson, Brooke J., Mackintosh, Colin G., Griffin, J. Frank T.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 15-09-2010
Amsterdam: Elsevier
Subjects:
Age Factors
Animals
cell physiology
Cervus elaphus
deer
Deer - immunology
domestication
farmed animal species
Flow Cytometry
histology
ileum
immunity
Involution
jejunum
morphogenesis
ontogeny
Peyer's patches
Peyer's Patches - immunology
postnatal development
Red deer
Ruminantia
seasonal variation
Thymus
thymus gland
Thymus Gland - immunology
tissue weight
young animals
Peyer's patches
Red deer
Involution
Thymus
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Summary:In young ruminants, as in most animals, the thymus and Peyer's patches (PP) play a key role in immune function. In sheep and cattle it has been shown that they follow a recognisable pattern of development throughout early life but a study of these tissues in red deer ( Cervus elaphus) had not been previously conducted. Red deer are undergoing increasing domestication thus it was important to determine whether there were any significant differences between species. Samples from the thymus, jejunal PP and ileal PP were obtained from deer at 1, 1.5, 2, 3, 6, 9 and 12 months of age. Tissues were measured, processed and comparisons between the equivalent tissues in cattle and sheep were made. The thymus and Peyer's patches of red deer were observed to follow similar patterns of development and involution as in other ruminant species. The thymus was also observed to show a seasonal decrease in weight and cellular composition possibly due to nutritional and environmental stresses. Moreover, evidence for the prevailing idea that the ileal PP acts as primary lymphoid tissue in ruminants was obtained.
Bibliography:http://dx.doi.org/10.1016/j.vetimm.2010.04.014
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0165-2427
1873-2534
DOI:10.1016/j.vetimm.2010.04.014