Anti-DNA antibodies in the blood of patients with schizophrenia possess DNA-hydrolyzing activity

Introduction Autoantibodies (Abs) to different neuronal receptors and DNA were detected in the blood of patients with schizophrenia. Abs hydrolyzing DNA were detected in pool of polyclonal autoantibodies in autoimmune and infectious diseases, such catalytic Abs were named abzymes. Objectives To inve...

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Bibliographic Details
Published in:	European psychiatry Vol. 33; no. S1; pp. S247 - S248
Main Authors:	Ermakov, E, Smirnova, L, Sinyanskii, L, Dobrygina, D, Semke, A, Nevinsky, G, Buneva, V, Ivanova, S
Format:	Journal Article
Language:	English
Published:	Elsevier Masson SAS 01-03-2016
Subjects:	Internal Medicine Psychiatry
Online Access:	Get full text
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Summary:	Introduction Autoantibodies (Abs) to different neuronal receptors and DNA were detected in the blood of patients with schizophrenia. Abs hydrolyzing DNA were detected in pool of polyclonal autoantibodies in autoimmune and infectious diseases, such catalytic Abs were named abzymes. Objectives To investigate the level of anti-DNA antibodies and DNA-hydrolyzing activity of IgG from the serum of patients with schizophrenia depending on leading clinical symptoms. Aims – To measure the concentration of anti-DNA Abs in serum of patients with leading positive and negative symptoms; – to determine DNA-hydrolyzing activity of IgG. Methods In our study, 51 patients were included. The levels of antiDNA Abs were determined using ELISA. DNA-hydrolyzing activity was detected as the level(%) of supercoiled pBluescript DNA transition in circular and linear forms. Statistical analysis was performed in “Statistica 9.0”. Results Anti-DNA Abs of patients with schizophrenia not only bind DNA, but quite efficiently hydrolyze the substrate. IgG of patient with schizophrenia were shown to possess DNA hydrolyzing activity. It should be noted that DNAase activity of IgG in patients with schizophrenia with a negative symptoms was significantly higher, than in patients with positive symptoms ( Table 1 ). Conclusions The data show a correlation with the level of DNase activity and leading symptoms of patients with schizophrenia.
ISSN:	0924-9338 1778-3585
DOI:	10.1016/j.eurpsy.2016.01.628