Search Results - "Dobrusin, E M"

Structure-Based Design of a Potent, Selective, and Irreversible Inhibitor of the Catalytic Domain of the erbB Receptor Subfamily of Protein Tyrosine Kinases by Singh, Juswinder, Dobrusin, Ellen M, Fry, David W, Haske, Taraneh, Whitty, Adrian, McNamara, Dennis J

“…We report the use of structure-based drug design to create a selective erbB-1 (a.k.a. epidermal growth factor receptor) and erbB-2 (a.k.a. neu/her2 growth…”
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Substrate Specificity of the Protein Tyrosine Phosphatases by Zhang, Zhong-Yin, Thieme-Sefler, Andrea M., Maclean, Derek, McNamara, Dennis J., Dobrusin, Ellen M., Sawyer, Tomi K., Dixon, Jack E.

“…The substrate specificity of a recombinant protein tyrosine phosphatase (PTPase) was probed using synthetic phosphotyrosine-containing peptides corresponding…”
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Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase 1B by Milarski, K L, Zhu, G, Pearl, C G, McNamara, D J, Dobrusin, E M, MacLean, D, Thieme-Sefler, A, Zhang, Z Y, Sawyer, T, Decker, S J

“…Protein tyrosine phosphatases all contain a conserved cysteine that forms an intermediate thiophosphate ester bond during tyrosine phosphate hydrolysis. A…”
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Tyrosine Kinase Inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(Phenylamino)pyrido[d]pyrimidine Acrylamides as Irreversible Inhibitors of the ATP Binding Site of the Epidermal Growth Factor Receptor by Smaill, Jeff B, Palmer, Brian D, Rewcastle, Gordon W, Denny, William A, McNamara, Dennis J, Dobrusin, Ellen M, Bridges, Alexander J, Zhou, Hairong, Showalter, H. D. Hollis, Winters, R. Thomas, Leopold, Wilbur R, Fry, David W, Nelson, James M, Slintak, Veronika, Elliot, William L, Roberts, Billy J, Vincent, Patrick W, Patmore, Sandra J

“…A series of 6- and 7-acrylamide derivatives of the 4-(phenylamino)quinazoline and -pyridopyrimidine classes of epidermal growth factor receptor (EGFR)…”
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Specific, Irreversible Inactivation of the Epidermal Growth Factor Receptor and erbB2, by a New Class of Tyrosine Kinase Inhibitor by Fry, David W., Bridges, Alexander J., Denny, William A., Doherty, Annette, Greis, Kenneth D., Hicks, James L., Hook, Kenneth E., Keller, Paul R., Leopold, Wilbur R., Loo, Joseph A., McNamara, Dennis J., Nelson, James M., Sherwood, Veronika, Smaill, Jeff B., Trumpp-Kallmeyer, Susanne, Dobrusin, Ellen M.

“…A class of high-affinity inhibitors is disclosed that selectively target and irreversibly inactivate the epidermal growth factor receptor tyrosine kinase…”
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Determinants of Substrate Recognition in the Protein-tyrosine Phosphatase, PTP1 (∗) by Zhang, Zhong-Yin, Walsh, Amy B., Wu, Li, McNamara, Dennis J., Dobrusin, Ellen M., Miller, W. Todd

“…Photoaffinity labeling has been used to identify amino acids involved in recognition of protein substrates by the protein-tyrosine phosphatase PTP1. The…”
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Identification of amino acids in the N-terminal SH2 domain of phospholipase C gamma 1 important in the interaction with epidermal growth factor receptor by Gergel, J R, McNamara, D J, Dobrusin, E M, Zhu, G, Saltiel, A R, Miller, W T

“…Photoaffinity labeling and site-directed mutagenesis have been used to identify amino acid residues of the phospholipase C gamma 1 (PLC gamma 1) N-terminal SH2…”
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Tyrosine Kinase Inhibitors. 3. Structure-Activity Relationships for Inhibition of Protein Tyrosine Kinases by Nuclear-Substituted Derivatives of 2,2'-Dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide) by Rewcastle, Gordon W, Palmer, Brian D, Dobrusin, Ellen M, Fry, David W, Kraker, Alan J, Denny, William A

“…A series of indole-substituted 2,2'-dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamides) were prepared and evaluated for their ability to inhibit the tyrosine…”
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Tyrosine kinase inhibitors. 1. Structure-activity relationships for inhibition of epidermal growth factor receptor tyrosine kinase activity by 2,3-dihydro-2-thioxo-1H-indole-3-alkanoic acids and 2,2'-dithiobis(1H-indole-3-alkanoic acids) by Thompson, Andrew M, Rewcastle, Gordon W, Tercel, Moana, Dobrusin, Ellen M, Fry, David W, Kraker, Alan J, Denny, William A

“…A series of 2,3-dihydro-2-thioxo-1H-indole-3-alkanoic acids, and their methyl esters were prepared, the majority by oxidation of 1H-indole-3-alkanoic acids…”
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Differentiation of peptide molecular recognition by phospholipase Cγ‐1 Src homology‐2 domain and a mutant Tyr phosphatase PTP1bC215S by Maclean, Derek, Sefler, Andrea M., Zhu, Guochang, Decker, Stuart J., Saltiel, Alan R., Singh, Juswinder, Mcnamara, Dennis, Dobrusin, Ellen M., Sawyer, Tomi K.

“…Activated epidermal growth factor receptor (EGFR) undergoes autophosphorylation on several cytoplasmic tyrosine residues, which may then associate with the src…”
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Design of a potent peptide inhibitor of the epidermal growth factor receptor tyrosine kinase utilizing sequences based on the natural phosphorylation sites of phospholipase C-gamma 1 by Fry, D W, McMichael, A, Singh, J, Dobrusin, E M, McNamara, D J

“…Peptides that possess primary sequences identical to segments surrounding the natural phosphorylation sites of phospholipase C-gamma 1 (i.e., tyrosines 472,…”
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Pyrido[2,3-d]pyrimidin-7-ones as Specific Inhibitors of Cyclin-Dependent Kinase 4 by VanderWel, Scott N, Harvey, Patricia J, McNamara, Dennis J, Repine, Joseph T, Keller, Paul R, Quin, John, Booth, R. John, Elliott, William L, Dobrusin, Ellen M, Fry, David W, Toogood, Peter L

“…Inhibition of the cell cycle kinase, cyclin-dependent kinase-4 (Cdk4), is expected to provide an effective method for the treatment of proliferative diseases…”
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Structure–activity relationships for 2-anilino-6-phenylpyrido[2,3- d]pyrimidin-7(8 H)-ones as inhibitors of the cellular checkpoint kinase Wee1 by Palmer, Brian D., Smaill, Jeff B., Rewcastle, Gordon W., Dobrusin, Ellen M., Kraker, Alan, Moore, Charles W., Steinkampf, Randall W., Denny, William A.

“…2-Anilino-6-phenylpyrido[2,3- d]pyrimidin-7(8 H)-ones are inhibitors of c-Src and Wee1 kinases. Selectivity for c-Src was not markedly changed by 6-phenyl ring…”
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Inhibition of binding of phospholipase C gamma 1 SH2 domains to phosphorylated epidermal growth factor receptor by phosphorylated peptides by McNamara, D J, Dobrusin, E M, Zhu, G, Decker, S J, Saltiel, A R

“…A series of tyrosine-containing peptides 1-12: [formula: see text] (six pairs with and without the tyrosine phosphorylated) has been synthesized. The peptides…”
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2-Aminoquinazoline inhibitors of cyclin-dependent kinases by Bathini, Yadagiri, Singh, Inderjit, Harvey, Patricia J., Keller, Paul R., Singh, Rajeshwar, Micetich, Ronald G., Fry, David W., Dobrusin, Ellen M., Toogood, Peter L.

“…The inhibition of cyclin-dependent kinase 4 (Cdk4) causes cell cycle arrest and restores a checkpoint that is absent in the majority of tumor cells. Compounds…”
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Tyrosine kinase inhibitors. III: Structure-activity relationships for inhibition of protein tyrosine kinase by nuclear-substituted derivatives of 2,2'-dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide) by REWCASTLE, G. W, PALMER, B. D, DOBRUSIN, E. M, FRY, D. W, KRAKER, A. J, DENNY, W. A

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Tyrosine kinase inhibitors. I: Structure-activity relationships for inhibition of epidermal growth factor receptor tyrosine kinase activity by 2,3-dihydro-2-thioxo-1H-indole-3-alkanoic acids and 2,2'-dithiobis(1H-indole-3-alkanoic acids) by THOMPSON, A. M, REWCASTLE, G. W, TERCEL, M, DOBRUSIN, E. M, FRY, D. W, KRAKER, A. J, DENNY, W. A

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Substrates specificity of the protein tyrosine phosphatases by ZHONG-YIN ZHANG, THIEME-SEFLER, A. M, MACLEAN, D, MCNAMARA, D. J, DOBRUSIN, E. M, SAWYER, T. K, DIXON, J. E

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