Search Results - "Dobrucki, J."

Imaging of cellular DNA damage responses by Dobrucki, J.

“…Induction of DNA damage elicits a complex set of reactions in a mammalian cell, including signaling, recruitment and accumulation of repair factors at the site…”
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Stage‐specific embryonic antigen‐4 as a novel marker of ductal cells of human eccrine sweat glands by Borowczyk‐Michalowska, J., Zimolag, E., Waligorska, A., Dobrucki, J., Madeja, Z., Drukala, J.

“…Summary Background Different populations of unipotent or multipotent stem cells have been identified in human epidermis and its appendages. It is well…”
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Activation of new replication foci under conditions of replication stress by Rybak, P, Waligórska, A, Bujnowicz, Ł, Hoang, A, Dobrucki, J W

“…DNA damage, binding of drugs to DNA or a shortage of nucleotides can decrease the rate or completely halt the progress of replication forks. Although the…”
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DNA repair toolbox – cellular ability to repair multiple simultaneously induced single-strand DNA breaks by Szelest, O., Kurleto, D., Dobrucki, J. W.

“…Cellular capacity to repair DNA damage is limited, partly due to a fact that the number of copies of nuclear proteins available for a task of DNA repair is…”
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Relationship between DNA damage response, initiated by camptothecin or oxidative stress, and DNA replication, analyzed by quantitative 3D image analysis by Berniak, K., Rybak, P., Bernas, T., Zarębski, M., Biela, E., Zhao, H., Darzynkiewicz, Z., Dobrucki, J. W.

“…A method of quantitative analysis of spatial (3D) relationship between discrete nuclear events detected by confocal microscopy is described and applied in…”
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Spatial heterogeneity of dynamics of H1 linker histone by Bernas, T., Brutkowski, W., Zarębski, M., Dobrucki, J.

“…Linker histone H1 participates in maintaining higher order chromatin structures. It is a dynamic protein that binds to DNA and exchanges rapidly with a mobile…”
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Minimizing photobleaching during confocal microscopy of fluorescent probes bound to chromatin: role of anoxia and photon flux by BERNAS, T., ZARȨBSKI, M., COOK, R. R., DOBRUCKI, J. W.

“…Summary Exposure to light can destroy the ability of a molecule to fluoresce. Such photobleaching limits the use of fluorescence and confocal microscopy in…”
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Single- and double strand breaks induced by proton beam radiation in human uveal melanoma cells by Jasińska, K, Berniak, K, Olko, P, Romanowska-Dixon, B, Urbańska, K, Dobrucki, J, Elas, M

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Radiation induced DNA damage in human uveal melanoma cells by Jasińska, K, Berniak, K, Olko, P, Romanowska-Dixon, B, Urbańska, K, Dobrucki, J, Elas, M

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Interaction of oxygen-sensitive luminescent probes Ru(phen)(3)(2+) and Ru(bipy)(3)(2+) with animal and plant cells in vitro. Mechanism of phototoxicity and conditions for non-invasive oxygen measurements by Dobrucki, J W

“…Understanding the role of oxygen in the physiology, pathophysiology and radio- and chemosensitivity of animal cells requires accurate and non-invasive…”
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Chromatin condensation and sensitivity of DNA in situ to denaturation during cell cycle and apoptosis — a confocal microscopy study by Dobrucki, J, Darzynkiewicz, Z

“…The goal of this study was to construct high resolution 3D confocal images of regions of condensed and extended chromatin in cell nuclei and individual…”
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The Role of Plasma Membrane in Bioreduction of Two Tetrazolium Salts, MTT, and CTC by Bernas, Tytus, Dobrucki, Jurek W.

“…Despite widespread use of various tetrazolium assays, the mechanisms of bioreduction of these compounds have not been fully elucidated. We investigated the…”
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Hepatoma HepG2 cells as a model for in vitro studies on mitochondrial toxicity of antiviral drugs: which correlation with the patient? by Pinti, M, Troiano, L, Nasi, M, Ferraresi, R, Dobrucki, J, Cossarizza, A

“…Currently, drugs have been synthesised that can significantly delay the course of several viral infections, including those provoked by HBV, HCV or HIV, but…”
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Confocal Fluorescence Imaging of Photosensitized DNA Denaturation in Cell Nuclei by Bernas, Tytus, Asem, Elikplimi K., Robinson, J. Paul, Cook, Peter R., Dobrucki, Jurek W.

“…The double-stranded helical structure of DNA is maintained in part by hydrogen bonds between strands and by stacking interactions between adjacent purine and…”
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Backscattered light confocal imaging of intracellular MTT-formazan crystals by Bernas, Tytus, Dobrucki, Jurek W.

“…Metabolically active animal and plant cells reduce MTT tetrazolium salt to a corresponding nonfluorescent formazan. Reduction of MTT by viable cells is…”
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Differential effects of oncostatin M and leukaemia inhibitory factor expression in astrocytoma cells by Kasza, A, Rogowski, K, Kilarski, W, Sobota, R, Bernas, T, Dobrucki, J, Travis, J, Koj, A, Bugno, M, Kordula, T

“…The effects of the production of two closely related cytokines, oncostatin M (OSM) and leukaemia inhibitory factor (LIF), by astrocytoma cells were…”
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703 - Single- and double strand breaks induced by proton beam radiation in human uveal melanoma cells by Jasińska, K., Berniak, K., Olko, P., Romanowska-Dixon, B., Urbańska, K., Dobrucki, J., Elas, M.

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108 - Radiation induced DNA damage in human uveal melanoma cells by Jasińska, K., Berniak, K., Olko, P., Romanowska-Dixon, B., Urbańska, K., Dobrucki, J., Elas, M.

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Anchorage-dependent chick embryo fibroblasts synthesise DNA and proliferate when cultured in multilayered sheets suspended among glass fibres by Czyz, J, Dobrucki, J, Korohoda, W

“…Chick embryo fibroblasts (CEFs) spontaneously form multicellular and multilayered sheets suspended on the network of glass fibres which are stabilized by…”
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Nonperturbing test for cytotoxicity in isolated cells and spheroids, using electron paramagnetic resonance by Dobrucki, J W, Sutherland, R M, Swartz, H M

“…Electron paramagnetic resonance imaging (EPRI) and EPR spectroscopy of nitroxides have been applied to detect and quantify cytotoxic effects in mammalian cells…”
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