Search Results - "Dobrowolski, Paul"

Quantitative Measurement of JWH-018 and JWH-073 Metabolites Excreted in Human Urine by Moran, Cindy L, Le, Vi-Huyen, Chimalakonda, Krishna C, Smedley, Amy L, Lackey, Felisia D, Owen, Suzanne N, Kennedy, Paul D, Endres, Gregory W, Ciske, Fred L, Kramer, James B, Kornilov, Andrei M, Bratton, L. D, Dobrowolski, Paul J, Wessinger, William D, Fantegrossi, William E, Prather, Paul L, James, Laura P, Radominska-Pandya, Anna, Moran, Jeffery H

“…“K2/SPICE” products are commonly laced with aminoalkylindole synthetic cannabinoids (i.e., JWH-018 and JWH-073) and are touted as “legal” marijuana…”
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Solid-Phase Extraction and Quantitative Measurement of Omega and Omega-1 Metabolites of JWH-018 and JWH-073 in Human Urine by Chimalakonda, Krishna C, Moran, Cindy L, Kennedy, Paul D, Endres, Gregory W, Uzieblo, Adam, Dobrowolski, Paul J, Fifer, E. Kim, Lapoint, Jeff, Nelson, Lewis S, Hoffman, Robert S, James, Laura P, Radominska-Pandya, Anna, Moran, Jeffery H

“…The aminoalkylindole agonists JWH-018 and JWH-073 are contained in “K2/SPICE” products sold as “legal marijuana”. Previous human metabolic studies have…”
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An outbreak of acute delirium from exposure to the synthetic cannabinoid AB-CHMINACA by Tyndall, Joseph A., Gerona, Roy, De Portu, Giuliano, Trecki, Jordan, Elie, Marie-Carmelle, Lucas, Judith, Slish, John, Rand, Kenneth, Bazydlo, Lindsay, Holder, Martina, Ryan, Matthew F., Myers, Paul, Iovine, Nicole, Plourde, Michelle, Weeks, Emily, Hanley, James R., Endres, Greg, St. Germaine, Danielle, Dobrowolski, Paul J., Schwartz, Michael

“…Background: Synthetic cannabinoid containing products are a public health threat as reflected by a number of outbreaks of serious adverse health effects over…”
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Synthesis of 2,4-Di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indoles, Including Antiasthma Clinical Candidate PNU-142731A by Bundy, Gordon L, Banitt, Lee S, Dobrowolski, Paul J, Palmer, John R, Schwartz, Theresa M, Zimmermann, David C, Lipton, Michael F, Mauragis, Michael A, Veley, Michael F, Appell, Robert B, Clouse, Robert C, Daugs, Edward D

“…Two syntheses are described for 1-[(2,4-di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indol-9-yl)-acetyl]pyrrolidine hydrochloride (PNU-142731A), a clinical candidate in…”
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12,13-Isobaccatin III. Taxane Enol Esters (12,13-Isotaxanes) by Kelly, Robert C, Wicnienski, Nancy A, Gebhard, Ilse, Qualls, Samuel J, Han, Fusen, Dobrowolski, Paul J, Nidy, Eldon G, Johnson, Roy A

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Targeted Metabolomic Approach for Assessing Human Synthetic Cannabinoid Exposure and Pharmacology by Patton, Amy L, Seely, Kathryn A, Chimalakonda, Krishna C, Tran, Johnny P, Trass, Matthew, Miranda, Art, Fantegrossi, William E, Kennedy, Paul D, Dobrowolski, Paul, Radominska-Pandya, Anna, McCain, Keith R, James, Laura P, Endres, Gregory W, Moran, Jeffery H

“…Designer synthetic cannabinoids like JWH-018 and AM2201 have unique clinical toxicity. Cytochrome-P450-mediated metabolism of each leads to the generation of…”
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12,13-Isotaxanes:  Synthesis of New Potent Analogs and X-ray Crystallographic Confirmation of Structure by Johnson, Roy A, Dobrowolski, Paul J, Nidy, Eldon G, Gebhard, Ilse, Qualls, Samuel J, Wicnienski, Nancy A, Kelly, Robert C, Pitts, Thomas W, Lopes, Narima M, DeKoning, Thomas F, Mattern, Sally J, Weed, Sheldon D, McGovren, J. Patrick, Chidester, Constance G

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Intramolecular 2 + 2 Cycloaddition in a Baccatin. From a Tetracyclic to a Hexacyclic Molecule by Nidy, Eldon G, Wicnienski, Nancy A, Chidester, Constance G, Dobrowolski, Paul J, Mizsak, Stephen A, Toy, Arthur, Runge, Thomas A, Qualls, Samuel J, Kelly, Robert C, Johnson, Roy A

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Production Scale Synthesis of the Non-Nucleoside Reverse Transcriptase Inhibitor Atevirdine Mesylate (U-87,201E) by Perrault, William R, Shephard, K. Paul, LaPean, Lori A, Krook, Mark A, Dobrowolski, Paul J, Lyster, Mark A, McMillan, Moses W, Knoechel, Donald J, Evenson, Gerald N, Watt, William, Pearlman, Bruce A

“…A practical synthesis of atevirdine mesylate, Pharmacia & Upjohn's first-generation non-nucleoside reverse transcriptase (RT) inhibitor for treatment of AIDS,…”
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Hydrogen fluoride catalyzed migration of side chain protecting groups onto Fmoc during solid phase peptide synthesis. Characterization by CF-FAB analysis of carboxypeptidase digestions and NMR spectroscopy by Grode, S H, Strother, D S, Runge, T A, Dobrowolski, P J

“…The solid-phase synthesis of the N alpha-Fmoc analog of protein kinase C substrate (PKCS, Lys-Arg-Ala-Lys-Ala-Lys-Thr-Thr-Lys-Lys-Arg) was characterized by low…”
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Problems associated with use of the benzyloxymethyl protecting group for histidines. Formaldehyde adducts formed during cleavage by hydrogen fluoride by Mitchell, M A, Runge, T A, Mathews, W R, Ichhpurani, A K, Harn, N K, Dobrowolski, P J, Eckenrode, F M

“…The use of N alpha-tert.-butyloxycarbonyl-N pi-benzyloxymethylhistidine in peptide synthesis resulted in significant levels of several different side products…”
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