Search Results - "Dobrinski, Kimberly P."

Clonal Evolution Enhances Leukemia-Propagating Cell Frequency in T Cell Acute Lymphoblastic Leukemia through Akt/mTORC1 Pathway Activation by Blackburn, Jessica S., Liu, Sali, Wilder, Jayme L., Dobrinski, Kimberly P., Lobbardi, Riadh, Moore, Finola E., Martinez, Sarah A., Chen, Eleanor Y., Lee, Charles, Langenau, David M.

“…Clonal evolution and intratumoral heterogeneity drive cancer progression through unknown molecular mechanisms. To address this issue, functional differences…”
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Extensive genetic diversity and substructuring among zebrafish strains revealed through copy number variant analysis by Brown, Kim H, Dobrinski, Kimberly P, Lee, Arthur S, Gokcumen, Omer, Mills, Ryan E, Shi, Xinghua, Chong, Wilson W. S, Chen, Jin Yun Helen, Yoo, Paulo, David, Sthuthi, Peterson, Samuel M, Raj, Towfique, Choy, Kwong Wai, Stranger, Barbara E, Williamson, Robin E, Zon, Leonard I, Freeman, Jennifer L, Lee, Charles

“…Copy number variants (CNVs) represent a substantial source of genomic variation in vertebrates and have been associated with numerous human diseases. Despite…”
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Expression and Function of Four Carbonic Anhydrase Homologs in the Deep-Sea Chemolithoautotroph Thiomicrospira crunogena by Dobrinski, Kimberly P, Boller, Amanda J, Scott, Kathleen M

“…The hydrothermal vent chemolithoautotroph Thiomicrospira crunogena grows rapidly in the presence of low concentrations of dissolved inorganic carbon (DIC) (=…”
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Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma by Chen, Eleanor Y, Dobrinski, Kimberly P, Brown, Kim H, Clagg, Ryan, Edelman, Elena, Ignatius, Myron S, Chen, Jin Yun Helen, Brockmann, Jillian, Nielsen, G Petur, Ramaswamy, Sridhar, Keller, Charles, Lee, Charles, Langenau, David M

“…Human cancer genomes are highly complex, making it challenging to identify specific drivers of cancer growth, progression, and tumor maintenance. To bypass…”
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Tissue-Specific eQTL in Zebrafish by Dobrinski, Kimberly P

“…Copy number variants (CNVs) refer to the loss or gain of copies of a genomic DNA region. While some CNVs may play a role in species evolution by enriching the…”
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Transcriptional Response of the Sulfur Chemolithoautotroph Thiomicrospira crunogena to Dissolved Inorganic Carbon Limitation by DOBRINSKI, Kimberly P, ENKEMANN, Steven A, YODER, Sean J, HALLER, Edward, SCOTT, Kathleen M

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Resolution of the Novel Immune-Type Receptor Gene Cluster in Zebrafish by Yoder, Jeffrey A., Litman, Ronda T., Mueller, M. Gail, Desai, Salil, Dobrinski, Kimberly P., Montgomery, Jennifer S., Buzzeo, Matthew P., Ota, Tatsuya, Amemiya, Chris T., Trede, Nikolaus S., Wei, Sheng, Djeu, Julie Y., Humphray, Sean, Jekosch, Kerstin, Jose A. Hernandez Prada, Ostrov, David A., Litman, Gary W., Herzenberg, Leonard A.

“…The novel immune-type receptor (NITR) genes encode a unique multigene family of leukocyte regulatory receptors, which possess an extracellular Ig variable (V)…”
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Genomic Amplification of an Endogenous Retrovirus in Zebrafish T-Cell Malignancies by Frazer, J. Kimble, Batchelor, Lance A., Bradley, Diana F., Brown, Kim H., Dobrinski, Kimberly P., Lee, Charles, Trede, Nikolaus S.

“…Genomic instability plays a crucial role in oncogenesis. Somatically acquired mutations can disable some genes and inappropriately activate others. In…”
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An Interrogation of Shared and Unique Copy Number Variants Across Genetically Distinct Zebrafish Strains by Holden, Lindsay A, Wilson, Charles, Heineman, Zachary, Dobrinski, Kimberly P, Brown, Kim H

“…Zebrafish (Danio rerio) are a widely utilized model system for human disorders, but common laboratory strains have distinct behavioral and physiological…”
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BRCA1 185delAG Mutation Enhances Interleukin-1β Expression in Ovarian Surface Epithelial Cells by Roman, Jesse, Dobrinski, Kimberly P., Linger, Rebecca J., Mohamed, Mai, Woolery, Kamisha T., Kruk, Patricia A.

“…Familial history remains the strongest risk factor for developing ovarian cancer (OC) and is associated with germline BRCA1 mutations, such as the 185delAG…”
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The carbon-concentrating mechanism of the hydrothermal vent chemolithoautotroph Thiomicrospira crunogena by DOBRINSKI, Kimberly P, LONGO, Dana L, SCOTT, Kathleen M

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Response of hydrothermal vent vestimentiferan Riftia pachyptila to differences in habitat chemistry by Scott, Kathleen M., Boller, Amanda J., Dobrinski, Kimberly P., Le Bris, Nadine

“…Vestimentiferan tubeworms, which rely on intracellular sulfide-oxidizing autotrophic bacteria for organic carbon, flourish at deep-sea hydrothermal vents…”
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Molecular Cytogenetic Methodologies and a BAC Probe Panel Resource for Genomic Analyses in the Zebrafish by Dobrinski, Kimberly P., Brown, Kim H., Freeman, Jennifer L., Lee, Charles

“…Molecular cytogenetics is a field that emerged in the 1980s, based on a technique referred to as fluorescence in situ hybridization, (FISH). Using FISH…”
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Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish by Panagos, Patoula G, Dobrinski, Kimberly P, Chen, Xianghong, Grant, Amanda W, Traver, David, Djeu, Julie Y, Wei, Sheng, Yoder, Jeffrey A

“…The identification of C-type lectin (Group V) natural killer (NK) cell receptors in bony fish has remained elusive. Analyses of the Fugu rubripes genome…”
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BRCA1 185delAG mutation enhances Interleukin-1[beta] expression in ovarian surface epithelial cells by Woolery, Kamisha T, Mohamed, Mai, Linger, Rebecca J, Dobrinski, Kimberly P, Roman, Jesse, Kruk, Patricia A

“…Familial history remains the strongest risk factor for developing ovarian cancer (OC) and is associated with germline BRCA1 mutations, such as the 185delAG…”
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The genome of deep-sea vent chemolithoautotroph Thiomicrospira crunogena XCL-2 by Scott, Kathleen M, Sievert, Stefan M, Abril, Fereniki N, Ball, Lois A, Barrett, Chantell J, Blake, Rodrigo A, Boller, Amanda J, Chain, Patrick S G, Clark, Justine A, Davis, Carisa R, Detter, Chris, Do, Kimberly F, Dobrinski, Kimberly P, Faza, Brandon I, Fitzpatrick, Kelly A, Freyermuth, Sharyn K, Harmer, Tara L, Hauser, Loren J, Hügler, Michael, Kerfeld, Cheryl A, Klotz, Martin G, Kong, William W, Land, Miriam, Lapidus, Alla, Larimer, Frank W, Longo, Dana L, Lucas, Susan, Malfatti, Stephanie A, Massey, Steven E, Martin, Darlene D, McCuddin, Zoe, Meyer, Folker, Moore, Jessica L, Ocampo, Jr, Luis H, Paul, John H, Paulsen, Ian T, Reep, Douglas K, Ren, Qinghu, Ross, Rachel L, Sato, Priscila Y, Thomas, Phaedra, Tinkham, Lance E, Zeruth, Gary T

“…Presented here is the complete genome sequence of Thiomicrospira crunogena XCL-2, representative of ubiquitous chemolithoautotrophic sulfur-oxidizing bacteria…”
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Shared acquired genomic changes in zebrafish and human T-ALL by Rudner, L A, Brown, K H, Dobrinski, K P, Bradley, D F, Garcia, M I, Smith, A C H, Downie, J M, Meeker, N D, Look, A T, Downing, J R, Gutierrez, A, Mullighan, C G, Schiffman, J D, Lee, C, Trede, N S, Frazer, J K

“…T-cell acute lymphoblastic leukemia (T-ALL) is a challenging clinical entity with high rates of induction failure and relapse. To discover the genetic changes…”
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Abstract 1412: Cross-species array comparative genomic hybridization identifies novel driver genes in embryonal rhabdomyosarcoma by Chen, Eleanor, Dobrinski, Kimberly P., Brown, Kim H., Clagg, Ryan, Edelman, Elena, Ignatius, Myron, Brockmann, Jillian, Nielsen, G. Petur, Ramaswamy, Sridhar, Keller, Charles, Lee, Charles, Langenau, David M.

“…Human cancers are often associated with large chromosomal amplifications and deletions comprising megabases of sequence - making it challenging to identify…”
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Cross-Species Array Comparative Genomic Hybridization Identifies Novel Oncogenic Events in Zebrafish and Human Embryonal Rhabdomyosarcoma: e1003727 by Chen, Eleanor Y, Dobrinski, Kimberly P, Brown, Kim H, Clagg, Ryan, Edelman, Elena, Ignatius, Myron S, Chen, Jin YunHelen, Brockmann, Jillian, Nielsen, G Petur, Ramaswamy, Sridhar, Keller, Charles, Lee, Charles, Langenau, David M

“…Human cancer genomes are highly complex, making it challenging to identify specific drivers of cancer growth, progression, and tumor maintenance. To bypass…”
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Cross-Species Comparison of Acquired Genetic Changes In T Cell Malignancy by Rudner, Lynnie A., Brown, Kim H., Dobrinski, Kimberly P., Bradley, Diana F., Downie, Jonathan, Meeker, Nathan D., Smith, Alexandra, Garcia, Martha Iveth, Gutierrez, Alejandro, Mullighan, Charles, Look, A. Thomas, Downing, James R., Schiffman, Joshua D., Lee, Charles, Trede, Nikolaus, Frazer, J. Kimble

“…Abstract 1192 T cell acute lymphoblastic leukemia (T-ALL) is a challenging clinical entity. Over half of adult, and about 20% of pediatric, T-ALL patients…”
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