Search Results - "Dobrikova, Elena"

Ribosomal RACK1:Protein Kinase C βII Modulates Intramolecular Interactions between Unstructured Regions of Eukaryotic Initiation Factor 4G (eIF4G) That Control eIF4E and eIF3 Binding by Dobrikov, Mikhail I., Dobrikova, Elena Y., Gromeier, Matthias

“…The receptor for activated C kinase (RACK1), a conserved constituent of eukaryotic ribosomes, mediates phosphorylation of eukaryotic initiation factor…”
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Ribosomal RACK1:Protein Kinase C βII Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation by Dobrikov, Mikhail I., Dobrikova, Elena Y., Gromeier, Matthias

“…Eukaryotic ribosomes contain the high-affinity protein kinase C βII (PKCβII) scaffold, receptor for activated C kinase (RACK1), but its role in protein…”
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Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity by Mosaheb, Mubeen M., Dobrikova, Elena Y., Brown, Michael C., Yang, Yuanfan, Cable, Jana, Okada, Hideho, Nair, Smita K., Bigner, Darell D., Ashley, David M., Gromeier, Matthias

“…Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses can provide a…”
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Phosphorylation of Eukaryotic Translation Initiation Factor 4G1 (eIF4G1) by Protein Kinase Cα Regulates eIF4G1 Binding to Mnk1 by Dobrikov, Mikhail, Dobrikova, Elena, Shveygert, Mayya, Gromeier, Matthias

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PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma by Barton, Kelly L, Misuraca, Katherine, Cordero, Francisco, Dobrikova, Elena, Min, Hooney D, Gromeier, Matthias, Kirsch, David G, Becher, Oren J

“…Diffuse intrinsic pontine glioma (DIPG) is an incurable tumor that arises in the brainstem of children. To date there is not a single approved drug to…”
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Early enterovirus translation deficits extend viral RNA replication and elicit sustained MDA5-directed innate signaling by Dobrikov, Mikhail I, Dobrikova, Elena Y, Nardone-White, Dasean T, McKay, Zachary P, Brown, Michael C, Gromeier, Matthias

“…Multiple pattern recognition receptors sense vRNAs and initiate downstream innate signaling: endosomal Toll-like receptors (TLRs) 3, 7, and 8 and cytoplasmic…”
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p38α Mitogen-Activated Protein Kinase Depletion and Repression of Signal Transduction to Translation Machinery by miR-124 and -128 in Neurons by Lawson, Sarah K., Dobrikova, Elena Y., Shveygert, Mayya, Gromeier, Matthias

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PKR Binds Enterovirus IRESs, Displaces Host Translation Factors, and Impairs Viral Translation to Enable Innate Antiviral Signaling by Dobrikov, Mikhail I, Dobrikova, Elena Y, McKay, Zachary P, Kastan, Jonathan P, Brown, Michael C, Gromeier, Matthias

“…For RNA virus families except , viral RNA sensing includes Toll-like receptors and/or RIG-I. Picornavirus RNAs, whose 5' termini are shielded by a…”
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Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2 by Bryant, Jeffrey D., Brown, Michael C., Dobrikov, Mikhail I., Dobrikova, Elena Y., Gemberling, Sarah L., Zhang, Qing, Gromeier, Matthias

“…Death-associated protein 5 (DAP5) is an atypical isoform of the translation initiation scaffolds eukaryotic initiation factor 4GI (eIF4GI) and eIF4GII…”
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Herpes Simplex Virus Proteins ICP27 and UL47 Associate with Polyadenylate-Binding Protein and Control Its Subcellular Distribution by DOBRIKOVA, Elena, SHVEYGERT, Mayya, WALTERS, Robert, GROMEIER, Matthias

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Dynamic Regulation of the Translation Initiation Helicase Complex by Mitogenic Signal Transduction to Eukaryotic Translation Initiation Factor 4G by Dobrikov, Mikhail I., Dobrikova, Elena Y., Gromeier, Matthias

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Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase by Brown, Michael C, Bryant, Jeffrey D, Dobrikova, Elena Y, Shveygert, Mayya, Bradrick, Shelton S, Chandramohan, Vidyalakshmi, Bigner, Darell D, Gromeier, Matthias

“…Protein synthesis, the most energy-consuming process in cells, responds to changing physiologic priorities, e.g., upon mitogen- or stress-induced adaptations…”
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Oncolytic polio virotherapy of cancer by Brown, Michael C., Dobrikova, Elena Y., Dobrikov, Mikhail I., Walton, Ross W., Gemberling, Sarah L., Nair, Smita K., Desjardins, Annick, Sampson, John H., Friedman, Henry S., Friedman, Allan H., Tyler, Douglas S., Bigner, Darell D., Gromeier, Matthias

“…Recently, the century‐old idea of targeting cancer with viruses (oncolytic viruses) has come of age, and promise has been documented in early stage and several…”
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Tissue type-specific expression of the dsRNA-binding protein 76 and genome-wide elucidation of its target mRNAs by Neplioueva, Valentina, Dobrikova, Elena Y, Mukherjee, Neelanjan, Keene, Jack D, Gromeier, Matthias

“…RNA-binding proteins accompany all steps in the life of mRNAs and provide dynamic gene regulatory functions for rapid adjustment to changing extra- or…”
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Enterovirus 2A pro Cleavage of the YTHDF m 6 A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling by Kastan, Jonathan P, Tremblay, Martine W, Brown, Michael C, Trimarco, Joseph D, Dobrikova, Elena Y, Dobrikov, Mikhail I, Gromeier, Matthias

“…Enteroviruses (EV) deploy two proteases that mediate viral polyprotein cleavage and host cell manipulation. Here, we report that EV 2A proteases cleave all…”
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Harnessing virus tropism for dendritic cells for vaccine design by Mosaheb, Mubeen M, Brown, Michael C, Dobrikova, Elena Y, Dobrikov, Mikhail I, Gromeier, Matthias

“…•Dendritic cells are central protagonists in viral vector immunization approaches.•Many viruses naturally target dendritic cells for immune suppression.•Viral…”
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CReP mediates selective translation initiation at the endoplasmic reticulum by Kastan, Jonathan P, Dobrikova, Elena Y, Bryant, Jeffrey D, Gromeier, Matthias

“…Eukaryotic protein synthesis control at multiple levels allows for dynamic, selective responses to diverse conditions, but spatial organization of translation…”
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Attenuation of Neurovirulence, Biodistribution, and Shedding of a Poliovirus:Rhinovirus Chimera after Intrathalamic Inoculation in Macaca fascicularis by DOBRIKOVA, Elena Y, GOETZ, Christian, ESTEP, James E, GROMEIER, Matthias, WALTERS, Robert W, LAWSON, Sarah K, PEGGINS, James O, MUSZYNSKI, Karen, RUPPEL, Sheryl, POOLE, Karyol, GIARDINA, Steven L, VELA, Eric M

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Recombinant Oncolytic Poliovirus Eliminates Glioma In Vivo Without Genetic Adaptation to a Pathogenic Phenotype by Dobrikova, Elena Y, Broadt, Trevor, Poiley-Nelson, Judith, Yang, Xiaoyi, Soman, Gopalan, Giardina, Steve, Harris, Ray, Gromeier, Matthias

“…Many viruses, either naturally occurring or as a result of genetic manipulation, exhibit conditional replication in transformed cells. This principle is the…”
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Activation of cap-independent translation by variant eukaryotic initiation factor 4G in vivo by Kaiser, Constanze, Dobrikova, Elena Y, Bradrick, Shelton S, Shveygert, Mayya, Herbert, James T, Gromeier, Matthias

“…Protein synthesis is tightly controlled by assembly of an intricate ribonucleoprotein complex at the m(7)GTP-cap on eukaryotic mRNAs. Ensuing linear scanning…”
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