Search Results - "Dobrian, Anca D"

Functional and pathological roles of the 12- and 15-lipoxygenases by Dobrian, Anca D., Lieb, David C., Cole, Banumathi K., Taylor-Fishwick, David A., Chakrabarti, Swarup K., Nadler, Jerry L.

“…The 12/15-lipoxygenase enzymes react with fatty acids producing active lipid metabolites that are involved in a number of significant disease states. The…”
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Endothelial-to-Mesenchymal Transition in Human Adipose Tissue Vasculature Alters the Particulate Secretome and Induces Endothelial Dysfunction by Haynes, Bronson A, Yang, Li Fang, Huyck, Ryan W, Lehrer, Eric J, Turner, Joshua M, Barabutis, Nektarios, Correll, Vanessa L, Mathiesen, Allison, McPheat, William, Semmes, O John, Dobrian, Anca D

“…OBJECTIVE:Endothelial cells (EC) in obese adipose tissue (AT) are exposed to a chronic proinflammatory environment that may induce a mesenchymal-like phenotype…”
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Proton Pump Inhibitors: The Culprit for Barrett's Esophagus? by Alsalahi, Omran, Dobrian, Anca D

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STAT4 Deficiency Reduces Obesity-Induced Insulin Resistance and Adipose Tissue Inflammation by DOBRIAN, Anca D, GALKINA, Elena V, QIAN MA, HATCHER, Margaret, SABAI MYO AYE, BUTCHER, Mathew J, KAIWEN MA, HAYNES, Bronson A, KAPLAN, Mark H, NADLER, Jerry L

“…Signal transducer and activator of transcription (STAT) 4 is one of the seven members of the STAT family. STAT4 has a prominent role in mediating…”
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Endothelial cell-derived extracellular vesicles impair the angiogenic response of coronary artery endothelial cells by Carter, Nigeste, Mathiesen, Allison H., Miller, Noel, Brown, Michael, Colunga Biancatelli, Ruben M. L., Catravas, John D., Dobrian, Anca D.

“…Cardiovascular disease (CVD) is the most prominent cause of death of adults in the United States with coronary artery disease being the most common type of…”
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Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds by Cunnion, Kenji M, Krishna, Neel K, Pallera, Haree K, Pineros-Fernandez, Angela, Rivera, Magdielis Gregory, Hair, Pamela S, Lassiter, Brittany P, Huyck, Ryan, Clements, Mary A, Hood, Antoinette F, Rodeheaver, George T, Cottler, Patrick S, Nadler, Jerry L, Dobrian, Anca D

“…Diabetic non-healing wounds are a major clinical problem. The mechanisms leading to poor wound healing in diabetes are multifactorial but unresolved…”
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Pioglitazone Prevents Hypertension and Reduces Oxidative Stress in Diet-Induced Obesity by Dobrian, Anca D, Schriver, Suzanne D, Khraibi, Ali A, Prewitt, Russell L

“…ABSTRACT—The objective of this study was to determine the effect of pioglitazone on blood pressure (BP) and oxidative balance in obese, hypertensive,…”
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Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue by Haynes, Bronson A, Huyck, Ryan W, James, Ashley J, Carter, Meghan E, Gaafar, Omnia U, Day, Marjorie, Pinto, Avennette, Dobrian, Anca D

“…Obesity is accompanied by an extensive remodeling of adipose tissue primarily via adipocyte hypertrophy. Extreme adipocyte growth results in a poor response to…”
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Key Role of STAT4 Deficiency in the Hematopoietic Compartment in Insulin Resistance and Adipose Tissue Inflammation by Nadler, Jerry L., Lehrer, Eric J., Haynes, Bronson A., Hatcher, Margaret A., Glenn, Lindsey M., Ma, Kaiwen, Dobrian, Anca D., Kaplan, Mark H.

“…Visceral adipose tissue (AT) inflammation is linked to the complications of obesity, including insulin resistance (IR) and type 2 diabetes. Recent data from…”
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Peer-Developed Modules on Basic Biostatistics and Evidence-Based Medicine Principles for Undergraduate Medical Education by Mai, Daniel H, Taylor-Fishwick, Jonathan S, Sherred-Smith, William, Pang, Anthony, Yaworsky, Justin, Whitty, Sean, Lafever, Alex, Mcilvain, Cody, Schmitt, Mark, Rogers-Johnson, Michelle, Pace, April, Dobrian, Anca D

“…Evidence-based medicine (EBM) is pivotal in shaping patient care, yet it is challenging to incorporate into undergraduate medical education (UME) due to a lack…”
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Oxidative Stress in a Rat Model of Obesity-Induced Hypertension by Dobrian, Anca D, Davies, Michael J, Schriver, Suzanne D, Lauterio, Thomas J, Prewitt, Russell L

“…The mechanisms underlying the development of hypertension in obesity are not yet fully understood. We recently reported the development of hypertension in a…”
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Development of Hypertension in a Rat Model of Diet-Induced Obesity by Dobrian, Anca D, Davies, Michael J, Prewitt, Russell L, Lauterio, Thomas J

“…Although obesity is a risk factor for hypertension, the relationship between these 2 conditions is not well understood. Therefore, we examined some parameters…”
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Effect of salt on hypertension and oxidative stress in a rat model of diet-induced obesity by Dobrian, Anca D, Schriver, Suzanne D, Lynch, Terrie, Prewitt, Russell L

“…High-salt diet is known to induce or aggravate hypertension in animal models of hypertension and in humans. When Sprague-Dawley rats (n = 60) are fed a…”
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Lipids and immunoinflammatory pathways of beta cell destruction by Imai, Yumi, Dobrian, Anca D., Morris, Margaret A., Taylor-Fishwick, David A., Nadler, Jerry L.

“…Islet inflammation contributes to beta cell demise in both type 1 and type 2 diabetes. 12-Lipoxygenase (12-LO, gene expressed as ALOX12 in humans and 12-Lo in…”
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Role of Angiotensin II and Free Radicals in Blood Pressure Regulation in a Rat Model of Renal Hypertension by Dobrian, Anca D, Schriver, Suzanne D, Prewitt, Russell L

“…One-kidney, 1-clip rats (1K1C) or uninephrectomized controls were treated with either the superoxide dismutase mimetic tempol (0.5 mmol · kg · d), angiotension…”
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ADMA and NOS regulation in chronic renal disease: beyond the old rivalry for l-arginine by Dobrian, Anca D

“…Chronic kidney disease is associated with increased levels of assymetric N(G),N(G)-dimethylarginine (ADMA), which is predictive of increased mortality and…”
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Age‐associated vascular inflammation promotes monocytosis during atherogenesis by Du, Wei, Wong, Christine, Song, Yang, Shen, Hua, Mori, Daniel, Rotllan, Noemi, Price, Nathan, Dobrian, Anca D., Meng, Hailong, Kleinstein, Steven H., Fernandez‐Hernando, Carlos, Goldstein, Daniel R.

“…Summary Aging leads to a proinflammatory state within the vasculature without disease, yet whether this inflammatory state occurs during atherogenesis remains…”
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STAT4 Regulates the CD8 + Regulatory T Cell/T Follicular Helper Cell Axis and Promotes Atherogenesis in Insulin-Resistant Ldlr -/- Mice by Taghavie-Moghadam, Parésa L, Waseem, Tayab C, Hattler, Julian, Glenn, Lindsey M, Dobrian, Anca D, Kaplan, Mark H, Yang, Yi, Nurieva, Roza, Nadler, Jerry L, Galkina, Elena V

“…The metabolic syndrome and diabetic conditions support atherosclerosis, but the exact mechanisms for accelerated atherogenesis remain unclear. Although the…”
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Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats by Chakrabarti, Swarup K, Wen, Yeshao, Dobrian, Anca D, Cole, Banumathi K, Ma, Qian, Pei, Hong, Williams, Michael D, Bevard, Melissa H, Vandenhoff, George E, Keller, Susanna R, Gu, Jiali, Nadler, Jerry L

“…Central obesity is associated with low-grade inflammation that promotes type 2 diabetes and cardiovascular disease in obese individuals. The 12- and…”
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12- and 15-lipoxygenases in adipose tissue inflammation by Cole, Banumathi K., Lieb, David C., Dobrian, Anca D., Nadler, Jerry L.

“…► 12- and 15-lipoxygenases are expressed in many tissues, including adipose tissue. ► 12- and 15-lipoxygenases can generate pro- and anti-inflammatory…”
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