Search Results - "Dobránsky, Tomás"

Synaptic Elimination in Neurological Disorders by Cardozo, Pablo L, de Lima, Izabella B Q, Maciel, Esther M A, Silva, Nathália C, Dobransky, Tomas, Ribeiro, Fabíola M

“…Synapses are well known as the main structures responsible for transmitting information through the release and recognition of neurotransmitters by pre- and…”
Get full text

82-kDa choline acetyltransferase is in nuclei of cholinergic neurons in human CNS and altered in aging and Alzheimer disease by Gill, Sandeep K, Ishak, Margaret, Dobransky, Tomas, Haroutunian, Vahram, Davis, Kenneth L, Rylett, R. Jane

“…Abstract Cholinergic neurons express choline acetyltransferase (ChAT) which synthesizes acetylcholine. We show here for the first time that primate-specific…”
Get full text

Protein Kinase C Isoforms Differentially Phosphorylate Human Choline Acetyltransferase Regulating Its Catalytic Activity by Tomas Dobransky, Amanda Doherty-Kirby, Ae-Ri Kim, Dyanne Brewer, Gilles Lajoie, Rebecca J. Rylett

“…Choline acetyltransferase (ChAT) synthesizes acetylcholine in cholinergic neurons; regulation of its activity or response to physiological stimuli is poorly…”
Get full text

Gliotoxicity, reverse transcriptase activity and retroviral RNA in monocyte/macrophage culture supernatants from patients with multiple sclerosis by Ménard, Armelle, Amouri, Rim, Michel, Marlène, Marcel, Frédérique, Brouillet, Arthur, Belliveau, James, Geny, Christian, Deforges, Lionel, Malcus-Vocanson, Carine, Armstrong, Marilyn, Lyon-Caen, Olivier, Mandrand, Bernard, Dobránsky, Tomás, Rieger, François, Perron, Hervé

“…In investigating a possible link between a novel retroviral agent (provisionally called MSRV), recently characterised in multiple sclerosis (MS), and the…”
Get full text

Functional Characterization of Phosphorylation of 69-kDa Human Choline Acetyltransferase at Serine 440 by Protein Kinase C by Dobransky, Tomas, Davis, Wanda L., Rylett, R. Jane

“…Choline acetyltransferase, the enzyme that synthesizes the transmitter acetylcholine in cholinergic neurons, is a substrate for protein kinase C. In the…”
Get full text

Nuclear Localization of the 82-kDa Form of Human Choline Acetyltransferase by Resendes, M C, Dobransky, T, Ferguson, S S, Rylett, R J

“…Choline acetyltransferase is the enzyme catalyzing synthesis of the neurotransmitter acetylcholine in cholinergic neurons. In human, transcripts encoding two…”
Get full text

Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2 by BERETTA, L, DOBRANSKY, T, SOBEL, A

“…Stathmin is a ubiquitous, highly conserved phosphoprotein which most likely acts as a relay integrating various intracellular pathways regulating cell…”
Get full text

N-type Ca2+ channels are affected by full-length mutant huntingtin expression in a mouse model of Huntington’s disease by Silva, Flavia R, Miranda, Artur S, Santos, Rebeca P.M, Olmo, Isabella G, Zamponi, Gerald W, Dobransky, Tomas, Cruz, Jader S, Vieira, Luciene B, Ribeiro, Fabiola M

“…Abstract Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the amino-terminal region of the…”
Get full text

Identification of new phosphorylation sites of CD23 in B-cells of patients with chronic lymphocytic leukemia by Maďarová, Martina, Mucha, Rastislav, Hresko, Stanislav, Makarová, Zuzana, Gdovinová, Zuzana, Szilasiová, Jarmila, Vitková, Marianna, Guman, Tomáš, Štecová, Natalia, Dobransky, Tomas

“…•Pathology of CLL is associated with CD23 phoshorylation.•New phosphorylation sites of CD23 were identified in B-cells of patients with CLL.•Protein kinase C…”
Get full text

A model for dynamic regulation of choline acetyltransferase by phosphorylation by Dobransky, Tomas, Rylett, R. Jane

“…Choline acetyltransferase (ChAT) synthesizes the neurotransmitter acetylcholine (ACh) and is a phenotypic marker for cholinergic neurons. Cholinergic neurons…”
Get full text

A gliotoxic factor and multiple sclerosis by Ménard, Armelle, Amouri, Rim, Dobránsky, Tomáš, Charriaut-Marlangue, Christiane, Pierig, Régine, Cifuentes-Diaz, Carmen, Ghandour, Said, Belliveau, James, Gascan, Hughes, Hentati, Fayçal, Lyon-Caen, Olivier, Perron, Hervé, Rieger, François

“…The pathogenesis of multiple sclerosis (MS) is unknown. Searching for possible toxic factors, it was found that 3-day exposure to heat-treated cerebrospinal…”
Get full text

N-type Ca 2+ channels are affected by full-length mutant huntingtin expression in a mouse model of Huntington's disease by Silva, Flavia R, Miranda, Artur S, Santos, Rebeca P M, Olmo, Isabella G, Zamponi, Gerald W, Dobransky, Tomas, Cruz, Jader S, Vieira, Luciene B, Ribeiro, Fabiola M

“…Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the amino-terminal region of the…”
Get full text

Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI by Barlic, J, Andrews, J D, Kelvin, A A, Bosinger, S E, DeVries, M E, Xu, L, Dobransky, T, Feldman, R D, Ferguson, S S, Kelvin, D J

“…Chemoattractant-stimulated granule release from neutrophils, basophils and eosinophils is critical for the innate immune response against infectious bacteria…”
Get full text

REVIEW: A model for dynamic regulation of choline acetyltransferase by phosphorylation by Dobransky, Tomas, Rylett, R Jane

“…Choline acetyltransferase (ChAT) synthesizes the neurotransmitter acetylcholine (ACh) and is a phenotypic marker for cholinergic neurons. Cholinergic neurons…”
Get full text

β-Arrestins regulate a Ral-GDS-Ral effector pathway that mediates cytoskeletal reorganization by Ferguson, Stephen S. G, Bhattacharya, Moshmi, Anborgh, Pieter H, Babwah, Andy V, Dale, Lianne B, Dobransky, Tomas, Benovic, Jeffery L, Feldman, Ross D, Verdi, Joseph M, Rylett, R. Jane

“…beta-Arrestins are important in chemoattractant receptor-induced granule release, a process that may involve Ral-dependent regulation of the actin…”
Get full text

P3-377: Abeta (1-42) peptide regulates phosphorylation of nuclear choline acetyltransferase at threonine-456 by p38 kinase by Dobransky, Tomas, McLeod, Ryan Maththew, Rylett, Rebecca Jane

Get full text

Functional regulation of choline acetyltransferase by phosphorylation by DOBRANSKY, Tomas, RYLETT, R. Jane

“…Choline acetyltransferase (ChAT) catalyzes synthesis of acetylcholine (ACh) in cholinergic neurons. ACh synthesis is regulated by availability of precursors…”
Get full text

P4-177 Hierarchical phosphorylation of choline acetyltransferase by protein kinase-C and regulation of its enzymatic activity by Dobransky, Tomas, Doherty-Kirby, Amanda, Lajoie, Gilles, Rylett, Rebecca Jane

Get full text

Phosphorylation of 69-kDa choline acetyltransferase at threonine 456 in response to amyloid-beta peptide 1-42 by Dobransky, Tomas, Brewer, Dyanne, Lajoie, Gilles, Rylett, R Jane

“…Choline acetyltransferase synthesizes acetylcholine in cholinergic neurons. In the brain, these neurons are especially vulnerable to effects of beta-amyloid (A…”
Get full text

Identification and molecular characterization of Unc-33-like phosphoprotein (Ulip), a putative mammalian homolog of the axonal guidance-associated unc-33 gene product by Byk, T, Dobransky, T, Cifuentes-Diaz, C, Sobel, A

“…The control of neuritic extension and guidance is critical for the development, maturation, and regeneration of functional neuronal circuits. We identified a…”
Get full text