Search Results - "Doboszewska, Urszula"

The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders by Socała, Katarzyna, Doboszewska, Urszula, Szopa, Aleksandra, Serefko, Anna, Włodarczyk, Marcin, Zielińska, Anna, Poleszak, Ewa, Fichna, Jakub, Wlaź, Piotr

“…Emerging evidence indicates that the gut microbiota play a crucial role in the bidirectional communication between the gut and the brain suggesting that the…”
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Salvinorin A Does Not Affect Seizure Threshold in Mice by Socała, Katarzyna, Doboszewska, Urszula, Wlaź, Piotr

“…The κ-opioid receptor has recently gained attention as a new molecular target in the treatment of many psychiatric and neurological disorders including…”
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Effects of classic antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish by Pieróg, Mateusz, Socała, Katarzyna, Doboszewska, Urszula, Wyska, Elżbieta, Guz, Leszek, Szopa, Aleksandra, Serefko, Anna, Poleszak, Ewa, Wlaź, Piotr

“…The zebrafish is extensively used as a model organism for studying several disorders of the central nervous system (CNS), including epilepsy. Some antiseizure…”
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Role of Adipose Tissue Hormones in Pathogenesis of Cryptoglandular Anal Fistula by Włodarczyk, Marcin, Włodarczyk, Jakub, Maryńczak, Kasper, Waśniewska-Włodarczyk, Anna, Doboszewska, Urszula, Wlaź, Piotr, Dziki, Łukasz, Fichna, Jakub

“…The cryptoglandular perianal fistula is a common benign anorectal disorder that is managed mainly with surgery and in some cases may be an extremely…”
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Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity by Cui, R., Radziwoń-Zaleska, Maria, Nowak, Gabriel, Wlaź, Piotr, Doboszewska, Urszula, Młyniec, Katarzyna

“…Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that…”
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The involvement of the GPR39-Zn(2+)-sensing receptor in the pathophysiology of depression. Studies in rodent models and suicide victims by Młyniec, Katarzyna, Doboszewska, Urszula, Szewczyk, Bernadeta, Sowa-Kućma, Magdalena, Misztak, Paulina, Piekoszewski, Wojciech, Trela, Franciszek, Ostachowicz, Beata, Nowak, Gabriel

“…Zinc is one of the most important trace elements in our body. Patients suffering from depression show lower serum zinc levels compared to healthy controls…”
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SN003, a CRF 1 receptor antagonist, attenuates depressive-like behavior and detrusor overactivity symptoms induced by 13-cis-retinoic acid in rats by Wróbel, Andrzej, Doboszewska, Urszula, Rechberger, Ewa, Wlaź, Piotr, Rechberger, Tomasz

“…Overactive bladder (OAB) often co-exists with depression in women. The corticotropin-releasing factor (CRF) system participates in the pathophysiology of both…”
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Antidepressant-like activity of magnesium in the chronic mild stress model in rats: alterations in the NMDA receptor subunits by Pochwat, Bartłomiej, Szewczyk, Bernadeta, Sowa-Kucma, Magdalena, Siwek, Agata, Doboszewska, Urszula, Piekoszewski, Wojciech, Gruca, Piotr, Papp, Mariusz, Nowak, Gabriel

“…Recent data suggests that the glutamatergic system is involved in the pathophysiology and treatment of major depressive disorder (MDD) and that the…”
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Alterations of Serum Magnesium Concentration in Animal Models of Seizures and Epilepsy—The Effects of Treatment with a GPR39 Agonist and Knockout of the Gpr39 Gene by Doboszewska, Urszula, Sawicki, Jan, Sajnóg, Adam, Szopa, Aleksandra, Serefko, Anna, Socała, Katarzyna, Pieróg, Mateusz, Nieoczym, Dorota, Mlyniec, Katarzyna, Nowak, Gabriel, Barałkiewicz, Danuta, Sowa, Ireneusz, Wlaź, Piotr

“…Several ligands have been proposed for the GPR39 receptor, including the element zinc. The relationship between GPR39 and magnesium homeostasis has not yet…”
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Dietary Zinc Differentially Regulates the Effects of the GPR39 Receptor Agonist, TC-G 1008, in the Maximal Electroshock Seizure Test and Pentylenetetrazole-Kindling Model of Epilepsy by Doboszewska, Urszula, Socała, Katarzyna, Pieróg, Mateusz, Nieoczym, Dorota, Sawicki, Jan, Sajnóg, Adam, Szewczyk, Bernadeta, Mlyniec, Katarzyna, Sowa, Ireneusz, Barałkiewicz, Danuta, Wlaź, Piotr

“…The G-protein coupled receptor 39 (GPR39) is gaining increasing attention as a target for future drugs, yet there are gaps in the understanding of its…”
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Alterations of Bio-elements, Oxidative, and Inflammatory Status in the Zinc Deficiency Model in Rats by Doboszewska, Urszula, Szewczyk, Bernadeta, Sowa-Kućma, Magdalena, Noworyta-Sokołowska, Karolina, Misztak, Paulina, Gołębiowska, Joanna, Młyniec, Katarzyna, Ostachowicz, Beata, Krośniak, Mirosław, Wojtanowska-Krośniak, Agnieszka, Gołembiowska, Krystyna, Lankosz, Marek, Piekoszewski, Wojciech, Nowak, Gabriel

“…Our previous study showed that dietary zinc restriction induces depression-like behavior with concomitant up-regulation of the N -methyl- d -aspartate receptor…”
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Time course of zinc deprivation-induced alterations of mice behavior in the forced swim test by Młyniec, Katarzyna, Davies, Claire Linzi, Budziszewska, Bogusława, Opoka, Włodzimierz, Reczyński, Witold, Sowa-Kućma, Magdalena, Doboszewska, Urszula, Pilc, Andrzej, Nowak, Gabriel

“…Zinc is an important trace element essential for numerous bodily functions. It is believed that a deficiency of zinc can lead to various conditions, including…”
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GPR39 deorphanization: The long and winding road to eicosanoids and a crosstalk between GPR39 and hedgehog signaling in angiogenesis by Doboszewska, Urszula, Maret, Wolfgang, Wlaź, Piotr

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GPR39: An orphan receptor begging for ligands by Doboszewska, Urszula, Maret, Wolfgang, Wlaź, Piotr

“…[Display omitted] •GPR39 is an orphan GPCR of class A (rhodopsin family) that engages with Gq, Gs, G12/13, Gi, and β-arrestin.•GPR39 has constitutive…”
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GPCR oligomerization as a target for antidepressants: Focus on GPR39 by Mlyniec, Katarzyna, Siodłak, Dominika, Doboszewska, Urszula, Nowak, Gabriel

“…At present most of the evidence for the relevance of oligomerization for the pharmacology of depression comes from in vitro studies which identified oligomers,…”
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Targeting zinc metalloenzymes in coronavirus disease 2019 by Doboszewska, Urszula, Wlaź, Piotr, Nowak, Gabriel, Młyniec, Katarzyna

“…Several lines of evidence support a link between the essential element zinc and the coronavirus disease 2019 (COVID‐19). An important fact is that zinc is…”
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Zinc signaling and epilepsy by Doboszewska, Urszula, Młyniec, Katarzyna, Wlaź, Aleksandra, Poleszak, Ewa, Nowak, Gabriel, Wlaź, Piotr

“…Evidence from both preclinical and clinical studies suggest the importance of zinc homeostasis in seizures/epilepsy. Undoubtedly, zinc, via modulation of a…”
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Purinergic transmission in depressive disorders by Szopa, Aleksandra, Socała, Katarzyna, Serefko, Anna, Doboszewska, Urszula, Wróbel, Andrzej, Poleszak, Ewa, Wlaź, Piotr

“…Purinergic signaling involves the actions of purine nucleotides and nucleosides (such as adenosine) at P1 (adenosine), P2X, and P2Y receptors. Here, we present…”
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Effects of new antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish by Pieróg, Mateusz, Socała, Katarzyna, Doboszewska, Urszula, Wyska, Elżbieta, Guz, Leszek, Szopa, Aleksandra, Serefko, Anna, Poleszak, Ewa, Wlaź, Piotr

“…Several studies with larvae and adult zebrafish have shown that old and new antiseizure drugs (ASDs) produce discrepant results in seizure tests, locomotor…”
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Antidepressant-Like Activity of Typical Antidepressant Drugs in the Forced Swim Test and Tail Suspension Test in Mice Is Augmented by DMPX, an Adenosine A 2A Receptor Antagonist by Poleszak, Ewa, Szopa, Aleksandra, Bogatko, Karolina, Wyska, Elżbieta, Wośko, Sylwia, Świąder, Katarzyna, Doboszewska, Urszula, Wlaź, Aleksandra, Wróbel, Andrzej, Wlaź, Piotr, Serefko, Anna

“…Unsatisfactory therapeutic effects of currently used antidepressants force to search for new pharmacological treatment strategies. Recent research points to…”
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