Search Results - "Dobo, K."

Potential impurities in drug substances: Compound-specific toxicology limits for 20 synthetic reagents and by-products, and a class-specific toxicology limit for alkyl bromides by Bercu, J.P., Galloway, S.M., Parris, P., Teasdale, A., Masuda-Herrera, M., Dobo, K., Heard, P., Kenyon, M., Nicolette, J., Vock, E., Ku, W., Harvey, J., White, A., Glowienke, S., Martin, E.A., Custer, L., Jolly, R.A., Thybaud, V.

“…This paper provides compound-specific toxicology limits for 20 widely used synthetic reagents and common by-products that are potential impurities in drug…”
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The application of structure-based assessment to support safety and chemistry diligence to manage genotoxic impurities in active pharmaceutical ingredients during drug development by Dobo, Krista L., Greene, Nigel, Cyr, Michelle O., Caron, Stéphane, Ku, Warren W.

“…Starting materials and intermediates used to synthesize pharmaceuticals are reactive in nature and may be present as impurities in the active pharmaceutical…”
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An evaluation of the sensitivity of the Ames assay to discern low-level mutagenic impurities by Kenyon, Michelle O., Cheung, Jennifer R., Dobo, Krista L., Ku, Warren W.

“…Low level impurities often reside in active pharmaceutical ingredients (API). Some of these impurities are potentially genotoxic since reactive intermediates…”
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The influence of cellular apoptotic capacity on N-nitrosodimethylamine-induced loss of heterozygosity mutations in human cells by DOBO, K. L, EASTMOND, D. A, GROSOVSKY, A. J

“…The induction of loss of heterozygosity (LOH) by the environmental carcinogen N-nitrosodimethylamine (NDMA), and the factors that influence the recovery of LOH…”
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Sequence specific mutations induced by N-nitrosodimethylamine at two marker loci in metabolically competent human lymphoblastoid cells by DOBO, K. L, EASTMOND, D. A, GROSOVSKY, A. J

“…N-Nitrosodimethylamine (NDMA) is a potent mutagen and animal carcinogen to which many people are exposed through the consumption of contaminated food and the…”
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Fluorescent tubulin polymerization assay to characterize moa of genotoxic compounds — A validation study by Heard, P., Ackerman, J., Coffing, S., Dobo, K., Schuler, M.

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Extensive loss of heterozygosity accounts for differential mutation rate on chromosome 17q in human lymphoblasts by Dobo, K L, Giver, C R, Eastmond, D A, Rumbos, H S, Grosovsky, A J

“…In order to investigate the influence of loss of heterozygosity (LOH) events on mutation rate, we studied two closely related human lymphoblastoid cell lines,…”
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Role of oxygen radicals in the chromosomal loss and breakage induced by the quinone-forming compounds, hydroquinone and tert-butylhydroquinone by Dobo, K L, Eastmond, D A

“…The mechanisms by which two quinone-forming compounds, hydroquinone (HQ) and tert-butyl-hydroquinone (tBHQ), induce chromosomal loss and breakage in a…”
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Isolation and characterization of an R-prime plasmid from Rhizobium meliloti by Kiss, G B, Dobo, K, Dusha, I, Breznovits, A, Orosz, L, Vincze, E, Kondorosi, A

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A Strategy for the Risk Assessment of Human Genotoxic Metabolites by Dobo, Krista L, Obach, R. Scott, Luffer-Atlas, Debra, Bercu, Joel P

“…The role of metabolism in genotoxicity and carcinogenicity of many chemicals is well established. Accordingly, both in vitro metabolic activation systems and…”
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Overview of Genotoxic Impurities in Pharmaceutical Development by Bercu, Joel P., Dobo, Krista L., Gocke, Elmar, McGovern, Timothy J.

“…This symposium focuses on the management of genotoxic impurities in the synthesis of pharmaceuticals. Recent developments in both Europe and United States…”
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Vaginal candidiasis and its treatment with flavofungin, a new Hungarian antifungal antibiotic by TAKACS, I, URI, J, BAZSO, J, DOBO, K

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Cumulative familial incidence of juvenile non-insulin-dependent diabetes mellitus by Halmos, T, Dobó, K

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Air of the operating room and postoperative infections by Dobó, K, Vetró, G

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Attempt at estimating the incidence of juvenile non-insulin-dependent diabetes mellitus by Halmos, T, Dobó, K, Kautzky, L, Türke, I

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Hospital infections in surgery by Moldvai, S, Dobó, K, Troján, I

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