Search Results - "Dobler, Markus R"

Investigating the Structure-Activity Relationship of the Insecticidal Natural Product Rocaglamide by Hall, Roger G, Bruce, Ian, Cooke, Nigel G, Diorazio, Louis J, Cederbaum, Fredrik, Dobler, Markus R, Irving, Ed

“…The natural product Rocaglamide (1), isolated from the tree Aglaia elliptifolia, is a compelling but also challenging lead structure for crop protection. In…”
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Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors by Whitehead, Lewis, Dobler, Markus R., Radetich, Branko, Zhu, Yanyi, Atadja, Peter W., Claiborne, Tavina, Grob, Jonathan E., McRiner, Andrew, Pancost, Margaret R., Patnaik, Anup, Shao, Wenlin, Shultz, Michael, Tichkule, Ritesh, Tommasi, Ruben A., Vash, Brian, Wang, Ping, Stams, Travis

“…[Display omitted] ► Amino-acid derived HDAC8 small molecule inhibitors. ► α-Amino-ketone Zn binding allows synthetic access to the acetate release channel. ►…”
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Identification of Orally Available Naphthyridine Protein Kinase D Inhibitors by Meredith, Erik L, Ardayfio, Ophelia, Beattie, Kimberly, Dobler, Markus R, Enyedy, Istvan, Gaul, Christoph, Hosagrahara, Vinayak, Jewell, Charles, Koch, Keith, Lee, Wendy, Lehmann, HansJoerg, McKinsey, Timothy A, Miranda, Karl, Pagratis, Nikos, Pancost, Margaret, Patnaik, Anup, Phan, Dillon, Plato, Craig, Qian, Ming, Rajaraman, Vasumathy, Rao, Chang, Rozhitskaya, Olga, Ruppen, Thomas, Shi, Jie, Siska, Sarah J, Springer, Clayton, van Eis, Maurice, Vega, Richard B, von Matt, Anette, Yang, Lihua, Yoon, Taeyoung, Zhang, Ji-Hu, Zhu, Na, Monovich, Lauren G

“…A novel 2,6-naphthyridine was identified by high throughput screen (HTS) as a dual protein kinase C/D (PKC/PKD) inhibitor. PKD inhibition in the heart was…”
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Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 1: pyrido[2,3-b]pyrazines by Crowley, Patrick J, Lamberth, Clemens, Müller, Urs, Wendeborn, Sebastian, Nebel, Kurt, Williams, John, Sageot, Olivia -A, Carter, Neil, Mathie, Tanya, Kempf, Hans-Joachim, Godwin, Jeremy, Schneiter, Peter, Dobler, Markus R

“…BACKGROUND: The excellent fungicidal activity of [1,2,4]triazolo[1,5-a]pyrimidines suggested the search for further analogues with improved properties.RESULTS:…”
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Design and novel synthesis of aryl-heteroaryl-imidazole MAP kinase inhibitors by Dobler, Markus R

“…Inhibitors of the MAP kinase p38, potentially useful for the treatment of rheumatoid arthritis and inflammatory diseases, were found to exhibit antifungal…”
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Total synthesis of (±)-rocaglamide and some aryl analogues by Dobler, Markus R, Bruce, Ian, Cederbaum, Fredrik, Cooke, Nigel G, Diorazio, Louis J, Hall, Roger G, Irving, Ed

“…The insecticidal activity found for rocaglamide and its congeners, prompted us to establish a short and efficient synthesis of the natural product and some…”
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Total synthesis of (+)-epopromycin B and its analogues—studies on the inhibition of cellulose biosynthesis by Dobler, Markus R

“…The described inhibition of the cellulose biosynthesis by epopromycin B prompted us to establish a short and efficient synthesis of the natural product,…”
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