Search Results - "Doble, A."

Mercury in the human thyroid gland: Potential implications for thyroid cancer, autoimmune thyroiditis, and hypothyroidism by Pamphlett, Roger, Doble, Philip A, Bishop, David P

“…Mercury and other toxic metals have been suggested to be involved in thyroid disorders, but the distribution and prevalence of mercury in the human thyroid…”
Get full text

The pharmacology and mechanism of action of riluzole by DOBLE, A

“…The excitotoxic hypothesis of neurodegeneration has stimulated much interest in the possibility of using compounds that will block excitotoxic processes to…”
Get full text

Age-related accumulation of toxic metals in the human locus ceruleus by Pamphlett, Roger, Bishop, David P, Kum Jew, Stephen, Doble, Philip A

“…Damage to the locus ceruleus has been implicated in the pathogenesis of a number of neurological conditions. Locus ceruleus neurons accumulate toxic metals…”
Get full text

The distribution of toxic metals in the human retina and optic nerve head: Implications for age-related macular degeneration by Pamphlett, Roger, Cherepanoff, Svetlana, Too, Lay Khoon, Kum Jew, Stephen, Doble, Philip A, Bishop, David P

“…Toxic metals are suspected to play a role in the pathogenesis of age-related macular degeneration. However, difficulties in detecting the presence of multiple…”
Get full text

Elemental bioimaging shows mercury and other toxic metals in normal breast tissue and in breast cancers by Pamphlett, Roger, Satgunaseelan, Laveniya, Kum Jew, Stephen, Doble, Philip A, Bishop, David P

“…Exposure to toxic metals such as mercury has been proposed to be a risk factor for the development of breast cancer since some metals can promote genetic…”
Get full text

l‐3,4‐dihydroxyphenylalanine (l‐DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha‐synuclein mouse models of Parkinson's disease by Billings, Jessica L., Gordon, Sarah L., Rawling, Tristan, Doble, Philip A., Bush, Ashley I., Adlard, Paul A., Finkelstein, David I., Hare, Dominic J.

“…Treatment with the dopamine (DA) precursor l‐3,4‐dihydroxyphenylalanine (l‐DOPA) provides symptomatic relief arising from DA denervation in Parkinson's…”
Get full text

Elemental imaging shows mercury in cells of the human lateral and medial geniculate nuclei by Pamphlett, Roger, Kum Jew, Stephen, Doble, Philip A, Bishop, David P

“…Interference with the transmission of sensory signals along visual and auditory pathways has been implicated in the pathogenesis of hallucinations. The relay…”
Get full text

Dietary zinc and the control of Streptococcus pneumoniae infection by Eijkelkamp, Bart A, Morey, Jacqueline R, Neville, Stephanie L, Tan, Aimee, Pederick, Victoria G, Cole, Nerida, Singh, Prashina P, Ong, Cheryl-Lynn Y, Gonzalez de Vega, Raquel, Clases, David, Cunningham, Bliss A, Hughes, Catherine E, Comerford, Iain, Brazel, Erin B, Whittall, Jonathan J, Plumptre, Charles D, McColl, Shaun R, Paton, James C, McEwan, Alastair G, Doble, Philip A, McDevitt, Christopher A

“…Human zinc deficiency increases susceptibility to bacterial infection. Although zinc supplementation therapies can reduce the impact of disease, the molecular…”
Get full text

The Prostate Health Index adds predictive value to multi-parametric MRI in detecting significant prostate cancers in a repeat biopsy population by Gnanapragasam, V. J., Burling, K., George, A., Stearn, S., Warren, A., Barrett, T., Koo, B., Gallagher, F. A., Doble, A., Kastner, C., Parker, R. A.

“…Both multi-parametric MRI (mpMRI) and the Prostate Health Index (PHI) have shown promise in predicting a positive biopsy in men with suspected prostate cancer…”
Get full text

Mercury in the human adrenal medulla could contribute to increased plasma noradrenaline in aging by Pamphlett, Roger, Kum Jew, Stephen, Doble, Philip A., Bishop, David P.

“…Plasma noradrenaline levels increase with aging, and this could contribute to the sympathetic overactivity that is associated with essential hypertension and…”
Get full text

How are genetic test results being used by Australian life insurers? by Barlow-Stewart, K, Liepins, M, Doble, A, Otlowski, M

“…In Australia, the USA and many Asian countries the life insurance industry is self-regulated. Individuals must disclose genetic test results known to them in…”
Get full text

Short term outcomes of prostate biopsy in men tested for cancer by prostate specific antigen: prospective evaluation within ProtecT study by Rosario, Derek J, Lane, J Athene, Metcalfe, Chris, Donovan, Jenny L, Doble, Andy, Goodwin, Louise, Davis, Michael, Catto, James W F, Avery, Kerry, Neal, David E, Hamdy, Freddie C

“…Objectives To measure the effect of the adverse events within 35 days of transrectal ultrasound guided biopsy from the perspective of asymptomatic men having…”
Get full text

Appropriateness of acute-care antibiotic prescriptions for community-acquired infections and surgical antibiotic prophylaxis in England: analysis of 2016 national point prevalence survey data by Higgins, H., Freeman, R., Doble, A., Hood, G., Islam, J., Gerver, S., Henderson, K.L., Demirjian, A., Hopkins, S., Ashiru-Oredope, D.

“…BACKGROUNDEstimates of inappropriate prescribing can highlight key target areas for antimicrobial stewardship (AMS) and inform national targets.OBJECTIVESTo…”
Get full text

Oral Treatment with CuII(atsm) Increases Mutant SOD1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis by Roberts, B. R., Lim, N. K. H., McAllum, E. J., Donnelly, P. S., Hare, D. J., Doble, P. A., Turner, B. J., Price, K. A., Chun Lim, S., Paterson, B. M., Hickey, J. L., Rhoads, T. W., Williams, J. R., Kanninen, K. M., Hung, L. W., Liddell, J. R., Grubman, A., Monty, J.-F., Llanos, R. M., Kramer, D. R., Mercer, J. F. B., Bush, A. I., Masters, C. L., Duce, J. A., Li, Q.-X., Beckman, J. S., Barnham, K. J., White, A. R., Crouch, P. J.

“…Mutations in the metallo-protein Cu/Zn-superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS) in humans and an expression level-dependent…”
Get full text

High-Resolution Elemental Bioimaging of Ca, Mn, Fe, Co, Cu, and Zn Employing LA-ICP-MS and Hydrogen Reaction Gas by Lear, Jessica, Hare, Dominic J, Fryer, Fred, Adlard, Paul A, Finkelstein, David I, Doble, Philip A

“…Imaging of trace metal distribution in tissue sections by laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) is typically performed using…”
Get full text

Quantitative immuno-mass spectrometry imaging of skeletal muscle dystrophin by Bishop, David P., Westerhausen, Mika T., Barthelemy, Florian, Lockwood, Thomas, Cole, Nerida, Gibbs, Elizabeth M., Crosbie, Rachelle H., Nelson, Stanley F., Miceli, M. Carrie, Doble, Philip A., Wanagat, Jonathan

“…Emerging and promising therapeutic interventions for Duchenne muscular dystrophy (DMD) are confounded by the challenges of quantifying dystrophin. Current…”
Get full text

Development and implementation of a national antimicrobial stewardship surveillance system, with open access data sharing by Ashiru-Oredope, D., Budd, E.L., Doble, A., Cramp, E., Hendrick, A., Hopkins, S.

“…Public Health England (PHE) developed an antimicrobial stewardship (AMS) surveillance system and conducted a national pilot to test the feasibility of…”
Get full text

The Prevalence of Inorganic Mercury in Human Kidneys Suggests a Role for Toxic Metals in Essential Hypertension by Pamphlett, Roger, Doble, Philip A, Bishop, David P

“…The kidney plays a dominant role in the pathogenesis of essential hypertension, but the initial pathogenic events in the kidney leading to hypertension are not…”
Get full text

Elemental Analysis of Aging Human Pituitary Glands Implicates Mercury as a Contributor to the Somatopause by Pamphlett, Roger, Kum Jew, Stephen, Doble, Philip A, Bishop, David P

“…Growth hormone levels often decline on aging, and this "somatopause" is associated with muscle and bone loss, visceral adiposity and impaired cardiovascular…”
Get full text

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease by Finkelstein, David I, Billings, Jessica L, Adlard, Paul A, Ayton, Scott, Sedjahtera, Amelia, Masters, Colin L, Wilkins, Simon, Shackleford, David M, Charman, Susan A, Bal, Wojciech, Zawisza, Izabela A, Kurowska, Ewa, Gundlach, Andrew L, Ma, Sheri, Bush, Ashley I, Hare, Dominic J, Doble, Philip A, Crawford, Simon, Gautier, Elisabeth Cl, Parsons, Jack, Huggins, Penny, Barnham, Kevin J, Cherny, Robert A

“…Elevated iron in the SNpc may play a key role in Parkinson's disease (PD) neurodegeneration since drug candidates with high iron affinity rescue PD animal…”
Get full text