Search Results - "Dobi, Krisztina"
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Dual Inhibitors of AChE and BACE-1 for Reducing Aβ in Alzheimer’s Disease: From In Silico to In Vivo
Published in International journal of molecular sciences (01-11-2022)“…Alzheimer’s disease (AD) is a complex and widespread condition, still not fully understood and with no cure yet. Amyloid beta (Aβ) peptide is suspected to be a…”
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Rapid Identification of Potential Drug Candidates from Multi-Million Compounds' Repositories. Combination of 2D Similarity Search with 3D Ligand/Structure Based Methods and In Vitro Screening
Published in Molecules (Basel, Switzerland) (15-09-2021)“…Rapid in silico selection of target focused libraries from commercial repositories is an attractive and cost-effective approach in early drug discovery. If…”
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Robust Recombinant Expression of Human Placental Ribonuclease Inhibitor in Insect Cells
Published in Biomolecules (Basel, Switzerland) (08-02-2022)“…Ribonuclease inhibitors (RIs) are an indispensable biotechnological tool for the detection and manipulation of RNA. Nowadays, due to the outbreak of COVID-19,…”
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Identification of potential glutaminyl cyclase inhibitors from lead-like libraries by in silico and in vitro fragment-based screening
Published in Molecular diversity (01-02-2017)“…A glutaminyl cyclase (QC) fragment library was in silico selected by disconnection of the structure of known QC inhibitors and by lead-like 2D virtual…”
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Combination of 2D/3D ligand-based similarity search in rapid virtual screening from multimillion compound repositories. Selection and biological evaluation of potential PDE4 and PDE5 inhibitors
Published in Molecules (Basel, Switzerland) (28-05-2014)“…Rapid in silico selection of target focused libraries from commercial repositories is an attractive and cost effective approach. If structures of active…”
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Monoclonal antibody proteomics: Use of antibody mimotope displaying phages and the relevant synthetic peptides for mAb scouting
Published in Immunology letters (01-08-2014)“…Highlights • A workflow for selecting monoclonal antibodies for biomarker assays was devised. • Large mAB libraries where cognate antigens are not known were…”
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Combination of Pharmacophore Matching, 2D Similarity Search, and In Vitro Biological Assays in the Selection of Potential 5-HT6 Antagonists from Large Commercial Repositories
Published in Chemical biology & drug design (01-10-2015)“…Rapid in silico selection of target‐focused libraries from commercial repositories is an attractive and cost‐effective approach. If structures of active…”
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Combination of Pharmacophore Matching, 2D Similarity Search, and In Vitro Biological Assays in the Selection of Potential 5‐HT 6 Antagonists from Large Commercial Repositories
Published in Chemical biology & drug design (01-10-2015)“…Rapid in silico selection of target‐focused libraries from commercial repositories is an attractive and cost‐effective approach. If structures of active…”
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Rapid in silico selection of an MCHR1 antagonists’ focused library from multi-million compounds’ repositories: biological evaluation
Published in Medicinal chemistry research (01-03-2014)“…Target-focused libraries can be rapidly selected by 2D virtual screening methods from multimillion compounds’ databases if structures of active compounds are…”
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Selection of a melanine concentrating hormone receptor-1 (MCHR1) antagonists' focused library and its biological screening with AequoScreen
Published in Acta pharmaceutica Hungarica (2013)“…Target focused libraries can be rapidly selected by 2D virtual screening methods from multimillion compounds' repositories if structures of active compounds…”
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