Search Results - "Dobi, A."

miR-30 as a tumor suppressor connects EGF/Src signal to ERG and EMT by Kao, C-J, Martiniez, A, Shi, X-B, Yang, J, Evans, C P, Dobi, A, deVere White, R W, Kung, H-J

“…Src tyrosine kinase (Src) is implicated in the development of bone metastasis and castration resistance of prostate cancer. Src inhibitors are currently being…”
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TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation by Sun, C, Dobi, A, Mohamed, A, Li, H, Thangapazham, R L, Furusato, B, Shaheduzzaman, S, Tan, S-H, Vaidyanathan, G, Whitman, E, Hawksworth, D J, Chen, Y, Nau, M, Patel, V, Vahey, M, Gutkind, J S, Sreenath, T, Petrovics, G, Sesterhenn, I A, McLeod, D G, Srivastava, S

“…The high prevalence of TMPRSS2-ERG rearrangements (∼60%) in prostate cancer (CaP) leads to androgenic induction of the ETS -related gene ( ERG ) expression…”
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ERG oncoprotein expression in prostate cancer: clonal progression of ERG-positive tumor cells and potential for ERG-based stratification by Furusato, B, Tan, S-H, Young, D, Dobi, A, Sun, C, Mohamed, A A, Thangapazham, R, Chen, Y, McMaster, G, Sreenath, T, Petrovics, G, McLeod, D G, Srivastava, S, Sesterhenn, I A

“…Gene fusions prevalent in prostate cancer (CaP) lead to the elevated expression of the ERG proto-oncogene. ERG activation present in 50–70% of prostate tumors…”
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ERG protein expression and genomic rearrangement status in primary and metastatic prostate cancer—a comparative study of two monoclonal antibodies by Braun, M, Goltz, D, Adler, D, Vogel, W, Böhm, D, Scheble, V, Sotlar, K, Fend, F, Tan, S-H, Dobi, A, Kristiansen, G, Wernert, N, Perner, S

“…Background: Overexpression of the ERG protein is highly prevalent in prostate cancer (PCa) and commonly results from gene fusions involving the ERG gene…”
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Androgen receptor mutation (T877A) promotes prostate cancer cell growth and cell survival by Sun, C, Shi, Y, Xu, L L, Nageswararao, C, Davis, L D, Segawa, T, Dobi, A, McLeod, D G, Srivastava, S

“…Alteration of the AR functions due to amplification, overexpression and somatic mutation of the AR itself or altered interaction of AR with other cell growth…”
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Anterior tumors of the prostate: clinicopathological features and outcomes by Mygatt, J, Sesterhenn, I, Rosner, I, Chen, Y, Cullen, J, Morris-Gore, T, Barton, J, Dobi, A, Srivastava, S, McLeod, D, Brassell, S A

“…Background: To determine whether prostate cancers detected in the anterior vs posterior zones impact clinicopathological features and patient outcomes. This…”
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Study of a zirconium getter for purification of xenon gas by Dobi, A., Leonard, D.S., Hall, C., Kaufman, L.J., Langford, T., Slutsky, S., Yen, Y.-R.

“…Oxygen, nitrogen and methane purification efficiencies for a common zirconium getter are measured in 1050 Torr of xenon gas. Starting with impurity…”
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Detection of krypton in xenon for dark matter applications by Dobi, A., Davis, C., Hall, C., Langford, T., Slutsky, S., Yen, Y.-R.

“…We extend our technique for observing very small concentrations of impurities in xenon gas to the problem of krypton detection. We use a conventional mass…”
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Androgen receptor and prostate cancer by Richter, E, Srivastava, S, Dobi, A

“…Since the original observations of Huggins and Hodges that prostate cancers are androgen dependent, androgen ablation therapy has been the gold standard for…”
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Elevated osteonectin/SPARC expression in primary prostate cancer predicts metastatic progression by DeRosa, C A, Furusato, B, Shaheduzzaman, S, Srikantan, V, Wang, Z, Chen, Y, Siefert, M, Ravindranath, L, Young, D, Nau, M, Dobi, A, Werner, T, McLeod, D G, Vahey, M T, Sesterhenn, I A, Srivastava, S, Petrovics, G

“…Background: The majority of prostate cancers (CaP) are detected in early stages with uncertain prognosis. Therefore, an intensive effort is underway to define…”
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Role of multi-hnRNP nuclear complex in regulation of tumor suppressor ANXA7 in prostate cancer cells by Torosyan, Y, Dobi, A, Glasman, M, Mezhevaya, K, Naga, S, Huang, W, Paweletz, C, Leighton, X, Pollard, H B, Srivastava, M

“…Annexin-A7 (ANXA7) tumor suppressor role has been shown in various tumors, and ANXA7 expression has been particularly lost in androgen-resistant prostate…”
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EP-1299: Simultaneous integrated boost, a novel approach in the management of brain metastases by Dobi, A, Cserhati, A, Maráz, A, Mózes, P, Fodor, E, Együd, Z.S, Szabó, C.S, Kószó, R, Varga, Z, Gróh, F, Kahán, S.Z, Csenki, M, Barzó, P, Tiszlavicz, L, Hideghéty, K

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A simple high-sensitivity technique for purity analysis of xenon gas by Leonard, D.S., Dobi, A., Hall, L.J. Kaufman, C., Langford, T., Slutsky, S., Yen, Y.-R.

“…We report on the development and performance of a high-sensitivity purity-analysis technique for gaseous xenon. The gas is sampled at macroscopic pressure from…”
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ERG rearrangement and protein expression in the progression to castration-resistant prostate cancer by Gsponer, J R, Braun, M, Scheble, V J, Zellweger, T, Bachmann, A, Perner, S, Vlajnic, T, Srivastava, M, Tan, S-H, Dobi, A, Sesterhenn, I A, Srivastava, S, Bubendorf, L, Ruiz, C

“…Background: Approximately half of the prostate carcinomas are characterized by a chromosomal rearrangement fusing the androgen-regulated gene TMPRSS2 to the…”
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Prostate cancer gene expression signature of patients with high body mass index by Sharad, S, Srivastava, A, Ravulapalli, S, Parker, P, Chen, Y, Li, H, Petrovics, G, Dobi, A

“…The goal of this study was to evaluate prostate cancer gene expression signatures associated with elevated body mass index (BMI). Global gene expression…”
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UP-02.195 Clinicopathological Correlation of ERG Protein Expression in Single Focus Prostate Cancer by Sesterhenn, I, Tan, S, Dobi, A, Srivastava, S, McLeod, D, Brassell, S, Furusato, B

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UP-02.194 Improved Detection of Prostate Cancer by the Combined Application of ERG and AMACR Immunohistochemical Stainings in Prostate Biopsy Specimens by Lee, G, Russell, D, Parker, P, Sesterhenn, I, Cullen, J, Furusato, B, Dobi, A, McLeod, D, Srivastava, S, Moncur, J

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UP-02.170 Does Prostate Tumor Proximity to Surgical Margin in pT2 Disease Correlate with Biochemical Recurrence or All-cause Mortality? by Sesterhenn, I, Lee, G, Furusato, B, Cullen, J, Brassell, S, Dobi, A, Srivastava, S, McLeod, D

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Submillimolar Levels of Calcium Regulates DNA Structure at the Dinucleotide Repeat (TG/AC)n by Dobi, A., Agoston, D. V.

“…Submillimolar levels of calcium, similar to the physiological total (bound + free) intranuclear concentration (0.01-1 mM), induced a conformational change…”
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Transcriptome analyses of benign and malignant prostate epithelial cells in formalin-fixed paraffin-embedded whole-mounted radical prostatectomy specimens by Furusato, B, Shaheduzzaman, S, Petrovics, G, Dobi, A, Seifert, M, Ravindranath, L, Nau, M E, Werner, T, Vahey, M, McLeod, D G, Srivastava, S, Sesterhenn, I A

“…Formalin-fixed paraffin-embedded (FFPE) prostate specimens are rich sources of molecular pathological information. However, FFPE-based microarray analysis of…”
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