Search Results - "Dobbin, K."

Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds by Alsaihati, Burair A., Ho, Kun-Lin, Watson, Joshua, Feng, Yuan, Wang, Tianfang, Dobbin, Kevin K., Zhao, Shaying

“…Spontaneous canine cancers are valuable but relatively understudied and underutilized models. To enhance their usage, we reanalyze whole exome and genome…”
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Optimally splitting cases for training and testing high dimensional classifiers by Dobbin, Kevin K, Simon, Richard M

“…We consider the problem of designing a study to develop a predictive classifier from high dimensional data. A common study design is to split the sample into a…”
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Human basal-like breast cancer is represented by one of the two mammary tumor subtypes in dogs by Watson, Joshua, Wang, Tianfang, Ho, Kun-Lin, Feng, Yuan, Mahawan, Tanakamol, Dobbin, Kevin K, Zhao, Shaying

“…Background About 20% of breast cancers in humans are basal-like, a subtype that is often triple-negative and difficult to treat. An effective translational…”
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Validation of biomarkers to predict response to immunotherapy in cancer: Volume I — pre-analytical and analytical validation by Masucci, Giuseppe V., Cesano, Alessandra, Hawtin, Rachael, Janetzki, Sylvia, Zhang, Jenny, Kirsch, Ilan, Dobbin, Kevin K., Alvarez, John, Robbins, Paul B., Selvan, Senthamil R., Streicher, Howard Z., Butterfield, Lisa H., Thurin, Magdalena

“…Immunotherapies have emerged as one of the most promising approaches to treat patients with cancer. Recently, there have been many clinical successes using…”
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Pitfalls in the Use of DNA Microarray Data for Diagnostic and Prognostic Classification by Simon, Richard, Radmacher, Michael D., Dobbin, Kevin, McShane, Lisa M.

“…Many studies profiling gene expression in human cancers have been completed and are in progress. Some studies (19-22) attempt to build predictors of patient…”
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Guidelines for the development and incorporation of biomarker studies in early clinical trials of novel agents by Dancey, Janet E, Dobbin, Kevin K, Groshen, Susan, Jessup, J Milburn, Hruszkewycz, Andrew H, Koehler, Maria, Parchment, Ralph, Ratain, Mark J, Shankar, Lalitha K, Stadler, Walter M, True, Lawrence D, Gravell, Amy, Grever, Michael R

“…The National Cancer Institute (NCI) Investigational Drug Steering Committee (IDSC) charged the Biomarker Task Force to develop recommendations to improve the…”
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Comparison of microarray designs for class comparison and class discovery by DOBBIN, K, SIMON, R

“…Two-color microarray experiments in which an aliquot derived from a common RNA sample is placed on each array are called reference designs. Traditionally,…”
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Validation of biomarkers to predict response to immunotherapy in cancer: Volume II — clinical validation and regulatory considerations by Dobbin, Kevin K., Cesano, Alessandra, Alvarez, John, Hawtin, Rachael, Janetzki, Sylvia, Kirsch, Ilan, Masucci, Giuseppe V., Robbins, Paul B., Selvan, Senthamil R., Streicher, Howard Z., Zhang, Jenny, Butterfield, Lisa H., Thurin, Magdalena

“…There is growing recognition that immunotherapy is likely to significantly improve health outcomes for cancer patients in the coming years. Currently, while a…”
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How Large a Training Set is Needed to Develop a Classifier for Microarray Data? by DOBBIN, Kevin K, YINGDONG ZHAO, SIMON, Richard M

“…Purpose: A common goal of gene expression microarray studies is the development of a classifier that can be used to divide patients into groups with different…”
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Sample size planning for developing classifiers using high-dimensional DNA microarray data by Dobbin, Kevin K, Simon, Richard M

“…Many gene expression studies attempt to develop a predictor of pre-defined diagnostic or prognostic classes. If the classes are similar biologically, then the…”
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Canine spontaneous head and neck squamous cell carcinomas represent their human counterparts at the molecular level by Liu, Deli, Xiong, Huan, Ellis, Angela E, Northrup, Nicole C, Dobbin, Kevin K, Shin, Dong M, Zhao, Shaying

“…Spontaneous canine head and neck squamous cell carcinoma (HNSCC) represents an excellent model of human HNSCC but is greatly understudied. To better understand…”
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Sample size determination in microarray experiments for class comparison and prognostic classification by Dobbin, Kevin, Simon, Richard

“…Determining sample sizes for microarray experiments is important but the complexity of these experiments, and the large amounts of data they produce, can make…”
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Exploring Peer Support Needs of Caregivers for Youth with Mental Illness or Addictions Concerns in Family Navigation Services by Markoulakis, R., Turner, M., Wicik, K., Weingust, S., Dobbin, K., Levitt, A.

“…Roles for peer support workers are increasingly recognized as a valuable component of mental health and addictions (MHA) services. In youth MHA care,…”
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Defining adequate contact for transmission of Mycobacterium tuberculosis in an African urban environment by Castellanos, María Eugenia, Zalwango, Sarah, Kakaire, Robert, Ebell, Mark H, Dobbin, Kevin K, Sekandi, Juliet, Kiwanuka, Noah, Whalen, Christopher C

“…Background The risk of infection from respiratory pathogens increases according to the contact rate between the infectious case and susceptible contact, but…”
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Statistical design of reverse dye microarrays by Dobbin, K., Shih, J. H., Simon, R.

“…Motivation: In cDNA microarray experiments all samples are labelled with either Cy3 dye or Cy5 dye. Certain genes exhibit dye bias—a tendency to bind more…”
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Sample size requirements for training high-dimensional risk predictors by Dobbin, Kevin K, Song, Xiao

“…A common objective of biomarker studies is to develop a predictor of patient survival outcome. Determining the number of samples required to train a predictor…”
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Access and Utilization of Asthma Medications Among Patients Who Receive Care in Federally Qualified Health Centers by Ali, Asma M., Gaglioti, Anne H., Stone, Rebecca H., Crawford, Natalie D., Dobbin, Kevin K., Guglani, Lokesh, Young, Henry N.

“…Objectives: To describe access to and use of prescription asthma medications, and to assess factors associated with asthma exacerbation, healthcare…”
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Interlaboratory Comparability Study of Cancer Gene Expression Analysis Using Oligonucleotide Microarrays by DOBBIN, Kevin K, BEER, David G, MINNA, John D, GIRARD, Luc, MISEK, David E, TAYLOR, Jeremy M. G, HANASH, Samir, NAOKI, Katsuhiko, HAYES, D. Neil, LADD-ACOSTA, Christine, ENKEMANN, Steven A, VIALE, Agnes, MEYERSON, Matthew, GIORDANO, Thomas J, YEATMAN, Timothy J, GERALD, William L, JACOBSON, James W, CONLEY, Barbara, BUETOW, Kenneth H, HEISKANEN, Mervi, SIMON, Richard M

“…A key step in bringing gene expression data into clinical practice is the conduct of large studies to confirm preliminary models. The performance of such…”
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Yield of undetected tuberculosis and human immunodeficiency virus coinfection from active case finding in urban Uganda by Sekandi, J. N., List, J., Luzze, H., Yin, X-P., Dobbin, K., Corso, P. S., Oloya, J., Okwera, A., Whalen, C. C.

“…OBJECTIVES: To determine the yield of undetected active tuberculosis (TB), TB and human immunodeficiency virus (HIV) coinfection and the number needed to…”
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Characterizing dye bias in microarray experiments by Dobbin, K. K., Kawasaki, E. S., Petersen, D. W., Simon, R. M.

“…Motivation: Spot intensity serves as a proxy for gene expression in dual-label microarray experiments. Dye bias is defined as an intensity difference between…”
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