Search Results - "Doan, Thanh N."

Automated, Quantitative Screening Assay for Antiangiogenic Compounds Using Transgenic Zebrafish by TRAN, T. Cameron, SNEED, Blossom, SANDBERG, Eric M, HAIDER, Jamil, BLAVO, Delali, WHITE, Audrey, AIYEJORUN, Temitope, BARANOWSKI, Timothy C, RUBINSTEIN, Amy L, DOAN, Thanh N, DINGLEDINE, Raymond

“…Pathologic angiogenesis has emerged as an important therapeutic target in several major diseases. Zebrafish offer the potential for high-throughput drug…”
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Improved Cartilage Protection with Low Molecular Weight Hyaluronic Acid Hydrogel by Brackin, Riley B, McColgan, Gail E, Pucha, Saitheja A, Kowalski, Michael A, Drissi, Hicham, Doan, Thanh N, Patel, Jay M

“…Traumatic joint injuries are common, leading to progressive tissue degeneration and the development of osteoarthritis. The post-traumatic joint experiences a…”
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Differential Distribution and Function of Hyperpolarization-Activated Channels in Sensory Neurons and Mechanosensitive Fibers by Doan, Thanh N, Stephans, Kevin, Ramirez, Angelina N, Glazebrook, Patricia A, Andresen, Michael C, Kunze, Diana L

“…Sensory neurons express hyperpolarization-activated currents (I(H)) that differ in magnitude and kinetics within the populations. We investigated the…”
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Early signs of osteoarthritis in differing rat osteochondral defects by Chihab, Samir, Eng, Tracy, Kaiser, Jarred M., Khan, Nazir M., Doan, Thanh N., Drissi, Hicham

“…Preclinical models of osteochondral defects (OCDs) are fundamental test beds to evaluate treatment modalities before clinical translation. To increase the…”
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Osteoarthritis early-, mid- and late-stage progression in the rat medial meniscus transection model by McKinney, Jay M, Pucha, Krishna A, Bernard, Fabrice C, Brandon Dixon, J, Doan, Thanh N, Willett, Nick J

“…Osteoarthritis is a degenerative disease of synovial joints affecting all tissues, including articular cartilage and subchondral bone. Osteoarthritis animal…”
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Endothelin-1 inhibits size dependent lymphatic clearance of PEG-based conjugates after intra-articular injection into the rat knee by Doan, Thanh N., Bernard, Fabrice C., McKinney, Jay M., Dixon, J. Brandon, Willett, Nick J.

“…[Display omitted] Clearance of particles from the knee is an essential mechanism to maintain healthy joint homeostasis and critical to the delivery of drugs…”
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Sodium alginate microencapsulation of human mesenchymal stromal cells modulates paracrine signaling response and enhances efficacy for treatment of established osteoarthritis by McKinney, Jay M., Pucha, Krishna A., Doan, Thanh N., Wang, Lanfang, Weinstock, Laura D., Tignor, Benjamin T., Fowle, Kelsey L., Levit, Rebecca D., Wood, Levi B., Willett, Nick J.

“…Mesenchymal stromal cells (MSCs) have shown promise as osteoarthritis (OA) treatments; however, effective translation has been limited by high variability and…”
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Neuroprotection of MPTP-induced toxicity in zebrafish dopaminergic neurons by McKinley, Enid T., Baranowski, Timothy C., Blavo, Delali O., Cato, Candace, Doan, Thanh N., Rubinstein, Amy L.

“…Parkinson's disease is characterized by a severe loss of dopaminergic neurons resulting in a range of motor deficits. The neurotoxin…”
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Effect of Human Synovial Fluid From Osteoarthritis Patients and Healthy Individuals on Lymphatic Contractile Activity by Michalaki, Eleftheria, Nepiyushchikh, Zhanna, Rudd, Josephine M, Bernard, Fabrice C, Mukherjee, Anish, McKinney, Jay M, Doan, Thanh N, Willett, Nick J, Dixon, J Brandon

“…The lymphatic system has been proposed to play a crucial role in preventing the development and progression of osteoarthritis (OA). As OA develops and…”
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Multichromatic near-infrared imaging to assess interstitial lymphatic and venous uptake in vivo by Bernard, Fabrice C, Kaiser, Jarred, Raval, Sarvgna K, Nepiyushchikh, Zhanna V, Doan, Thanh N, Willett, Nick J, Dixon, J. Brandon

“…Significance: Changes in interstitial fluid clearance are implicated in many diseases. Using near-infrared (NIR) imaging with properly sized tracers could…”
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Genetic manipulation of the renin-angiotensin system by Doan, Thanh N, Gletsu, Nana, Cole, Justin, Bernstein, Kenneth E

“…The renin-angiotensin system is widely known for its importance in control of blood pressure, electrolyte homeostasis and volume regulation. Recently,…”
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Angiotensin II-induced hypertension in mice caused an increase in insulin secretion by Gletsu, Nana, Doan, Thanh N., Cole, Justin, Sutliff, Roy L., Bernstein, Kenneth E.

“…Insulin action was determined in a mouse model of human hypertension via chronic angiotensin II administration followed by a glucose tolerance test…”
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Angiotensin II signal transduction pathways by Sayeski, Peter P., Ali, M.Showkat, Semeniuk, Dan J., Doan, Thanh N., Bernstein, Kenneth E.

“…It has been 100 years since the discovery of renin by Tigerstedt and Bergman. Since that time, numerous discoveries have advanced our understanding of the…”
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High-throughput target validation in model organisms by Doan, Thanh N., Eilertson, Carmen D., Rubinstein, Amy L.

“…Modern drug discovery includes a progression from the identification of molecular targets pertinent to disease processes to the validation of those targets and…”
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