Search Results - "Doan, Ryan A"
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Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice
Published in Brain (London, England : 1878) (01-12-2016)“…Peripheral polyneuropathy is a common and dose-limiting side effect of many important chemotherapeutic agents. Most such neuropathies are characterized by…”
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Gene therapy targeting SARM1 blocks pathological axon degeneration in mice
Published in The Journal of experimental medicine (04-02-2019)“…Axonal degeneration (AxD) following nerve injury, chemotherapy, and in several neurological disorders is an active process driven by SARM1, an injury-activated…”
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Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program
Published in JCI insight (05-09-2019)“…Chemotherapy-induced peripheral neuropathy is one of the most prevalent dose-limiting toxicities of anticancer therapy. Development of effective therapies to…”
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TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance
Published in The Journal of neuroscience (27-04-2016)“…Complex nervous systems achieve proper connectivity during development and must maintain these connections throughout life. The processes of axon and synaptic…”
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Glia in the skin activate pain responses
Published in Science (American Association for the Advancement of Science) (16-08-2019)“…A newly discovered cell type forms a network that senses painful stimuli The ability to rapidly perceive and react to damaging stimuli is essential for…”
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