Search Results - "Doak, S.H."

In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines by Doak, S.H., Manshian, B., Jenkins, G.J.S., Singh, N.

“…► We consider current in vitro OECD genotoxicity tests for nanomaterials. ► Ames test does not appear to be suitable for nanomaterial assessment. ► In vitro…”
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Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker by Mohd Azmi, M.A., Tehrani, Z., Lewis, R.P., Walker, K.-A.D., Jones, D.R., Daniels, D.R., Doak, S.H., Guy, O.J.

“…In this article we present ultra-sensitive, silicon nanowire (SiNW)-based biosensor devices for the detection of disease biomarkers. An electrochemically…”
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Confounding experimental considerations in nanogenotoxicology by Doak, S.H., Griffiths, S.M., Manshian, B., Singh, N., Williams, P.M., Brown, A.P., Jenkins, G.J.S.

“…The development of novel nanomaterials with unique physico-chemical properties is increasing at a rapid rate, with potential applications across a broad range…”
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P13-07 Addition of physiologically relevant conditions has the potential to effect the toxicology of engineered nanomaterial hazards in an in vitro co-culture of the alveolar region of the lung by Meldrum, K., Doak, S.H., Clift, M.J.

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246 Utilisation of the DNA repair enzyme, N-Methylpurine DNA glycosylase, as a biomarker of oesophageal Cancer by Zair, Z, Griffiths, A.P, Doak, S.H, Johnson, G.E, Jenkins, G.J

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Nanofibre inhalation toxicology: providing the foundations for safe-by-design in-silico models by Burgum, M.J., Vogel, U., Clift, M.J.D., Doak, S.H.

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P13-18 Exposure models of nitrogen dioxide and particulate matter to assess mechanistic toxicology within advanced alveolar models by Bateman, J.W.P., Buckley, A., Robertson, S., Wright, M., Smith, R., Doak, S.H., Clift, M.J.D.

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P08-13 Quality evaluation and reviewof nanomaterial genotoxicity studies and data – a regulatory perspective by Siivola, K.M., Burgum, M.J., Suárez-Merino, B., Clift, M.J., Doak, S.H., Catalán, J.

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Development of a Liver Carcinoma Biomarker Panel in 3D HepG2 Liver Spheroids Following Exposure to Ag and Tio2 Nanomaterials by Conway, G.E., Llewellyn, S.V., Nymark, P., Vogel, U.B., Halappanavar, S., Jenkins, G.J., Clift, M.J., Doak, S.H.

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Understanding the biological impact of industrial engineered nanomaterials upon the alveolar epithelial barrier in vitro using occupational and in vivo relevant concentrations by Clift, M.J., Risby, H., Meldrum, K., Evans, S.J., Doak, S.H., Mitchell, S.

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In Vitro Toxicity Screening of an Inclusive Panel of Engineered Nanomaterials using an Advanced 3D Liver Model by Llewellyn, S.V., Conway, G.E., Shah, U.-K., Jenkins, G.J., Clift, M.J., Doak, S.H.

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P08-19 In vitro cytokinesis block micronucleus (CBMN) assay to evaluate the genotoxicity of multicomponent nanomaterials – a comparison with their individual counterparts by Saccardo, A., Evans, S.J., Tendero, M. Lopez, Balbuena, J., Cormano, J.M.L., Jenkins, G.J.S., Clift, M.J.D., Doak, S.H.

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P08-14 Investigating the cytotoxic and genotoxic potential of carbon nanotubes in human cells in vitro by Burgum, M.J., Saareleinen, H., Reinosa, J., Alcolea-Rodriguez, V., Fernandez, J., Dumit, V., Portela, R., Bañares, M., Catalán, J., Clift, M.J.D., Doak, S.H.

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Standardisation of mutagenicity testing approaches, tailored to the evaluation of engineered nanomaterials by Burgum, M.J., El Yamani, N., Sosnowska, A., Stolinski, F., Longhin, E.M., Mariussen, E., Runden-Pran, E., Jenkins, G., Clift, M.J.D., Puzyn, T., Dusinska, M., Doak, S.H.

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The bile acid deoxycholic acid (DCA) at neutral pH activates NF-κB and induces IL-8 expression in oesophageal cells in vitro by Jenkins, G.J.S., Harries, K., Doak, S.H., Wilmes, A., Griffiths, A.P., Baxter, J.N., Parry, J.M.

“…Barrett's oesophagus patients accumulate chromosomal defects during the histological progression to cancer, one of the most prominent of which is the…”
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Do dose response thresholds exist for genotoxic alkylating agents? by Jenkins, G.J.S., Doak, S.H., Johnson, G.E., Quick, E., Waters, E.M., Parry, J.M.

“…The demonstration and acceptance of dose response thresholds for genotoxins may have substantial implications for the setting of safe exposure levels. Here we…”
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Mechanisms of cell–cell adhesion identified by immunofluorescent labelling with quantum dots: A scanning near-field optical microscopy approach by Walker, K.-A.D., Doak, S.H., Dunstan, P.R.

“…Scanning near-field optical microscopy (SNOM) has been employed to simultaneously acquire high-resolution fluorescence images along with shear-force atomic…”
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Aneuploidy involving chromosome 1 may be an early predictive marker of intestinal type gastric cancer by Williams, L, Somasekar, A, Davies, D J, Cronin, J, Doak, S H, Alcolado, R, Williams, J G, Griffiths, A P, Baxter, J N, Jenkins, G J S

“…Intestinal type gastric cancer is a significant cause of mortality, therefore a better understanding of its molecular basis is required. We assessed if either…”
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Chromosome 4 hyperploidy represents an early genetic aberration in premalignant Barrett’s oesophagus by Doak, S H, Jenkins, G J S, Parry, E M, D’Souza, F R, Griffiths, A P, Toffazal, N, Shah, V, Baxter, J N, Parry, J M

“…Background and aims: Characterisation of the underlying molecular mechanisms that promote Barrett’s progression may ultimately lead to identification of…”
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Vitamin C inhibits nuclear factor-κB activation in oesophageal cells exposed to deoxycholic acid-potential cancer preventative treatment in patients with Barrett's metaplasia by Harries, K, Jenkins, G.J.S, Doak, S.H, Griffiths, A.P, Parry, J.M, Baxter, J.N

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